The cell biology of Smo signalling and its relationships with GPCRs

The Smoothened (Smo) signalling pathway participates in many developmental processes, contributing to the regulation of gene expression by controlling the activity of transcription factors belonging to the Gli family. The key elements of the pathway were identified by means of genetic screens carrie...

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Detalles Bibliográficos
Autores: Ruiz-Gómez, Ana, Molnar, Cristina, Holguín, Helena, Mayor Menéndez, Federico, Celis, José F. de
Tipo de recurso: artículo
Fecha de publicación:2006
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/4737
Acceso en línea:http://hdl.handle.net/10261/4737
Access Level:acceso abierto
Palabra clave:Hh signalling
Smoothened
GPCR
GRKs
β-arrestin
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spelling The cell biology of Smo signalling and its relationships with GPCRsRuiz-Gómez, AnaMolnar, CristinaHolguín, HelenaMayor Menéndez, FedericoCelis, José F. deHh signallingSmoothenedGPCRGRKsβ-arrestinThe Smoothened (Smo) signalling pathway participates in many developmental processes, contributing to the regulation of gene expression by controlling the activity of transcription factors belonging to the Gli family. The key elements of the pathway were identified by means of genetic screens carried out in Drosophila, and subsequent analysis in other model organisms revealed a high degree of conservation in both the proteins involved and in their molecular interactions. Recent analysis of the pathway, using a combination of biochemical and cell biological approaches, is uncovering the intricacies of Smo signalling, placing its elements in particular cellular compartments and qualifying the molecular processes involved. These include the synthesis, secretion and diffusion of the ligand, the activation of the receptor and the modifications in the activity of nuclear effectors. In this review we discuss recent advances in understanding biochemical and cellular aspects of Smo signalling, with particular focus in the similarities in the mechanism of signal transduction between Smo and other transmembrane proteins belonging to the G-Protein coupled receptors superfamily (GPCR).Peer reviewedElsevier200820082006info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501766290 bytesapplication/pdfhttp://hdl.handle.net/10261/4737reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1016/j.bbamem.2006.09.020info:eu-repo/semantics/openAccessoai:digital.csic.es:10261/47372026-05-22T06:33:51Z
dc.title.none.fl_str_mv The cell biology of Smo signalling and its relationships with GPCRs
title The cell biology of Smo signalling and its relationships with GPCRs
spellingShingle The cell biology of Smo signalling and its relationships with GPCRs
Ruiz-Gómez, Ana
Hh signalling
Smoothened
GPCR
GRKs
β-arrestin
title_short The cell biology of Smo signalling and its relationships with GPCRs
title_full The cell biology of Smo signalling and its relationships with GPCRs
title_fullStr The cell biology of Smo signalling and its relationships with GPCRs
title_full_unstemmed The cell biology of Smo signalling and its relationships with GPCRs
title_sort The cell biology of Smo signalling and its relationships with GPCRs
dc.creator.none.fl_str_mv Ruiz-Gómez, Ana
Molnar, Cristina
Holguín, Helena
Mayor Menéndez, Federico
Celis, José F. de
author Ruiz-Gómez, Ana
author_facet Ruiz-Gómez, Ana
Molnar, Cristina
Holguín, Helena
Mayor Menéndez, Federico
Celis, José F. de
author_role author
author2 Molnar, Cristina
Holguín, Helena
Mayor Menéndez, Federico
Celis, José F. de
author2_role author
author
author
author
dc.subject.none.fl_str_mv Hh signalling
Smoothened
GPCR
GRKs
β-arrestin
topic Hh signalling
Smoothened
GPCR
GRKs
β-arrestin
description The Smoothened (Smo) signalling pathway participates in many developmental processes, contributing to the regulation of gene expression by controlling the activity of transcription factors belonging to the Gli family. The key elements of the pathway were identified by means of genetic screens carried out in Drosophila, and subsequent analysis in other model organisms revealed a high degree of conservation in both the proteins involved and in their molecular interactions. Recent analysis of the pathway, using a combination of biochemical and cell biological approaches, is uncovering the intricacies of Smo signalling, placing its elements in particular cellular compartments and qualifying the molecular processes involved. These include the synthesis, secretion and diffusion of the ligand, the activation of the receptor and the modifications in the activity of nuclear effectors. In this review we discuss recent advances in understanding biochemical and cellular aspects of Smo signalling, with particular focus in the similarities in the mechanism of signal transduction between Smo and other transmembrane proteins belonging to the G-Protein coupled receptors superfamily (GPCR).
publishDate 2006
dc.date.none.fl_str_mv 2006
2008
2008
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/4737
url http://hdl.handle.net/10261/4737
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1016/j.bbamem.2006.09.020
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 766290 bytes
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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