Simplified screening approach of anabolic steroid esters using a compact atmospheric solid analysis probe mass spectrometric system

Due to the absence of chromatographic separation, ambient ionization mass spectrometry had the potential to improve the throughput of control laboratories in the last decades and will soon be an excellent approach for on-site use as well. In this study, an atmospheric solids analysis probe (ASAP) wi...

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Autores: Arrizabalaga Larrañaga, Ane, Zoontjes, Paul W., Lasaroms, Johan J.P., Nielen, Michel W.F., Blokland, Marco H.
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:dnet:addi________::37dfcf350bbb59336c5b0dfcf9e60a65
Acceso en línea:http://hdl.handle.net/10810/78794
Access Level:acceso abierto
Palabra clave:mass spectrometry
ambient ionization
on-site testing
atmospheric solid analysis probe
transportable MS
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spelling Simplified screening approach of anabolic steroid esters using a compact atmospheric solid analysis probe mass spectrometric systemArrizabalaga Larrañaga, AneZoontjes, Paul W.Lasaroms, Johan J.P.Nielen, Michel W.F.Blokland, Marco H.mass spectrometryambient ionizationon-site testingatmospheric solid analysis probetransportable MSDue to the absence of chromatographic separation, ambient ionization mass spectrometry had the potential to improve the throughput of control laboratories in the last decades and will soon be an excellent approach for on-site use as well. In this study, an atmospheric solids analysis probe (ASAP) with a single quadrupole mass analyzer has been evaluated to identify anabolic steroid esters rapidly. Sample introduction, applied scan time, and probe temperature were optimized for sensitivity. The in-source fragmentations of seventeen selected steroid esters, commonly found in illicit samples, were determined by applying different cone voltages (12, 20, 30, and 40 V). A spectral library was created for these steroid esters based on the four stages of in-source fragmentation spectra. The applicability of this method was demonstrated for the rapid identification of steroid esters in oily injection solutions, providing test results in less than 2 min.Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This project was financially supported by the Dutch Ministry of Agriculture, Nature and Food Quality (project KB-23–002-005).Springer Nature202620262022info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/78794reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoIngléshttps://link.springer.com/article/10.1007/s00216-022-03967-yinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/4.0/© The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International Licenseoai:dnet:addi________::37dfcf350bbb59336c5b0dfcf9e60a652026-06-18T09:23:17Z
dc.title.none.fl_str_mv Simplified screening approach of anabolic steroid esters using a compact atmospheric solid analysis probe mass spectrometric system
title Simplified screening approach of anabolic steroid esters using a compact atmospheric solid analysis probe mass spectrometric system
spellingShingle Simplified screening approach of anabolic steroid esters using a compact atmospheric solid analysis probe mass spectrometric system
Arrizabalaga Larrañaga, Ane
mass spectrometry
ambient ionization
on-site testing
atmospheric solid analysis probe
transportable MS
title_short Simplified screening approach of anabolic steroid esters using a compact atmospheric solid analysis probe mass spectrometric system
title_full Simplified screening approach of anabolic steroid esters using a compact atmospheric solid analysis probe mass spectrometric system
title_fullStr Simplified screening approach of anabolic steroid esters using a compact atmospheric solid analysis probe mass spectrometric system
title_full_unstemmed Simplified screening approach of anabolic steroid esters using a compact atmospheric solid analysis probe mass spectrometric system
title_sort Simplified screening approach of anabolic steroid esters using a compact atmospheric solid analysis probe mass spectrometric system
dc.creator.none.fl_str_mv Arrizabalaga Larrañaga, Ane
Zoontjes, Paul W.
Lasaroms, Johan J.P.
Nielen, Michel W.F.
Blokland, Marco H.
author Arrizabalaga Larrañaga, Ane
author_facet Arrizabalaga Larrañaga, Ane
Zoontjes, Paul W.
Lasaroms, Johan J.P.
Nielen, Michel W.F.
Blokland, Marco H.
author_role author
author2 Zoontjes, Paul W.
Lasaroms, Johan J.P.
Nielen, Michel W.F.
Blokland, Marco H.
author2_role author
author
author
author
dc.subject.none.fl_str_mv mass spectrometry
ambient ionization
on-site testing
atmospheric solid analysis probe
transportable MS
topic mass spectrometry
ambient ionization
on-site testing
atmospheric solid analysis probe
transportable MS
description Due to the absence of chromatographic separation, ambient ionization mass spectrometry had the potential to improve the throughput of control laboratories in the last decades and will soon be an excellent approach for on-site use as well. In this study, an atmospheric solids analysis probe (ASAP) with a single quadrupole mass analyzer has been evaluated to identify anabolic steroid esters rapidly. Sample introduction, applied scan time, and probe temperature were optimized for sensitivity. The in-source fragmentations of seventeen selected steroid esters, commonly found in illicit samples, were determined by applying different cone voltages (12, 20, 30, and 40 V). A spectral library was created for these steroid esters based on the four stages of in-source fragmentation spectra. The applicability of this method was demonstrated for the rapid identification of steroid esters in oily injection solutions, providing test results in less than 2 min.
publishDate 2022
dc.date.none.fl_str_mv 2022
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/78794
url http://hdl.handle.net/10810/78794
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://link.springer.com/article/10.1007/s00216-022-03967-y
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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