| Sumario: | Sphingolipids contain in their polar heads chemical groups allowing them to establish a complex network of H-bonds through different –OH and –NH–groups with other lipids in the bilayer. In the recent years the specific interaction of sphingomyelin with cholesterol has been examined, largely in the context of the “lipid raft” hypothesis. Formation of sphingomyelin - Ceramide complexes, proposed to exist in cell membranes in response to stress, has also been described. In addition, data demonstrating direct Cholesterol-Ceramide interaction are becoming available. Finally, a more recent emphasis on the variability of sphingolipids is advancing our knowledge in the field, as more studies are performed on different variants of sphingolipids, such as deoxysphingolipids, and reports on the effects of the N-acyl chain length or unsaturation are becoming available. This could be of importance in the currently growing field of developing ceramide-related therapeutic drugs or treatments for different illnesses, being the most relevant the cancer-related therapies.; Esfingolipidoek, beren buru polarrean dauzkaten talde polarren bidez, geruza bikoitzean existitzen diren beste lipido batzuekin sare konplexu bat eratzeko ahalmena daukate. Sare konplexu honen eraketa, -OH eta -NH- taldeekin hidrogeno-zubiak eratuz lortzen dute hain zuzen ere. Azken urteotan, lipido-urmaelaren hipotesiaren barruan, esfingomielinaren eta kolesterolaren arteko elkarrekintza espezifikoa asko ikertzen ari da, eta ikerketa honen emaitza da, estres-egoeren aurrean, zelulen mintzetan, esfingomielina-zeramida konplexuak sortzen direla proposatu izana. Gainera, kolesterol-zeramida elkarrekintzak ere gertatzen direla erakusten duten artikuluak gero eta ugariagoak dira. Existitzen diren esfingolipido moten inguruan jartzen ari den arretak gaiaren inguruko jakinduria handitzera garamatza. Izan ere, azkenaldian, deoxiesfingolipidoak bezalako esfingolipido aldakorren eta N-azil katearen luzerak edota lipidoen asegabetze-mailek daukaten efektuaren inguruko ikerketa gehiago egiten ari dira. Aldakortasun horiek garrantzitsuak izan daitezke zeramidarekin lotutako droga terapeutiko edota gaixotasun ezberdinen tratamenduak garatzeko; horien artetik garrantzitsuenak minbiziarekin lotutako terapiak dira.
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