Noninvasive spinal neuromodulation mitigates symptoms of idiopathic overactive bladder

Overactive bladder (OAB) affects 12 to 30% of the world's population. The accompanying urinary urgency, frequency and incontinence can have a profound effect on quality of life, leading to depression, social isolation, avoidance of sexual activity and loss of productivity. Conservative measures...

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Autores: Zhong, Hui, Liu, Emilie, Kohli, Priya, Perez, Laura, Edgerton, Victor|||0000-0001-6534-1875, Ginsberg, David, Gad, Parag|||0000-0001-8352-7614, Kreydin, Evgeniy|||0000-0001-8207-3809
Tipo de documento: artigo
Data de publicação:2022
País:España
Recursos:Universitat Autònoma de Barcelona
Repositório:Dipòsit Digital de Documents de la UAB
Idioma:inglês
OAI Identifier:oai:ddd.uab.cat:258895
Acesso em linha:https://ddd.uab.cat/record/258895
https://dx.doi.org/urn:doi:10.1186/s42234-022-00087-x
Access Level:Acceso aberto
Palavra-chave:Non-invasive spinal cord stimulation
Urge urinary incontinence
Overactive bladder
Lower urinary tract
Urodynamics
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spelling Noninvasive spinal neuromodulation mitigates symptoms of idiopathic overactive bladderZhong, HuiLiu, EmilieKohli, PriyaPerez, LauraEdgerton, Victor|||0000-0001-6534-1875Ginsberg, DavidGad, Parag|||0000-0001-8352-7614Kreydin, Evgeniy|||0000-0001-8207-3809Non-invasive spinal cord stimulationUrge urinary incontinenceOveractive bladderLower urinary tractUrodynamicsOveractive bladder (OAB) affects 12 to 30% of the world's population. The accompanying urinary urgency, frequency and incontinence can have a profound effect on quality of life, leading to depression, social isolation, avoidance of sexual activity and loss of productivity. Conservative measures such as lifestyle modification and pelvic floor physical therapy are the first line of treatment for overactive bladder. Patients who fail these may go on to take medications, undergo neuromodulation or receive injection of botulinum toxin into the bladder wall. While effective, medications have side effects and suffer from poor adherence. Neuromodulation and botulinum toxin injection are also effective but are invasive and not acceptable to some patients. We have developed a novel transcutaneous spinal cord neuromodulator (SCONE™,) that delivers multifrequency electrical stimulation to the spinal cord without the need for insertion or implantation of stimulating electrodes. Previously, multifrequency transcutaneous stimulation has been demonstrated to penetrate to the spinal cord and lead to motor activation of detrusor and external urethral sphincter muscles. Here, we report on eight patients with idiopathic overactive bladder, who underwent 12 weeks of SCONE™ therapy. All patients reported statistically significant clinical improvement in multiple symptoms of overactive bladder, such as urinary urgency, frequency and urge incontinence. In addition, patients reported significant symptomatic improvements as captured by validated clinical surveys. SCONE™ therapy represents the first of its kind therapy to treat symptoms of urgency, frequency and urge urinary incontinence in patients with OAB. The study was listed on clinicaltrials.gov ().Universitat Autònoma de Barcelona 22022-01-0120222022-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/258895https://dx.doi.org/urn:doi:10.1186/s42234-022-00087-xreponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2588952026-06-06T12:50:31Z
dc.title.none.fl_str_mv Noninvasive spinal neuromodulation mitigates symptoms of idiopathic overactive bladder
title Noninvasive spinal neuromodulation mitigates symptoms of idiopathic overactive bladder
spellingShingle Noninvasive spinal neuromodulation mitigates symptoms of idiopathic overactive bladder
Zhong, Hui
Non-invasive spinal cord stimulation
Urge urinary incontinence
Overactive bladder
Lower urinary tract
Urodynamics
title_short Noninvasive spinal neuromodulation mitigates symptoms of idiopathic overactive bladder
title_full Noninvasive spinal neuromodulation mitigates symptoms of idiopathic overactive bladder
title_fullStr Noninvasive spinal neuromodulation mitigates symptoms of idiopathic overactive bladder
title_full_unstemmed Noninvasive spinal neuromodulation mitigates symptoms of idiopathic overactive bladder
title_sort Noninvasive spinal neuromodulation mitigates symptoms of idiopathic overactive bladder
dc.creator.none.fl_str_mv Zhong, Hui
Liu, Emilie
Kohli, Priya
Perez, Laura
Edgerton, Victor|||0000-0001-6534-1875
Ginsberg, David
Gad, Parag|||0000-0001-8352-7614
Kreydin, Evgeniy|||0000-0001-8207-3809
author Zhong, Hui
author_facet Zhong, Hui
Liu, Emilie
Kohli, Priya
Perez, Laura
Edgerton, Victor|||0000-0001-6534-1875
Ginsberg, David
Gad, Parag|||0000-0001-8352-7614
Kreydin, Evgeniy|||0000-0001-8207-3809
author_role author
author2 Liu, Emilie
Kohli, Priya
Perez, Laura
Edgerton, Victor|||0000-0001-6534-1875
Ginsberg, David
Gad, Parag|||0000-0001-8352-7614
Kreydin, Evgeniy|||0000-0001-8207-3809
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Non-invasive spinal cord stimulation
Urge urinary incontinence
Overactive bladder
Lower urinary tract
Urodynamics
topic Non-invasive spinal cord stimulation
Urge urinary incontinence
Overactive bladder
Lower urinary tract
Urodynamics
description Overactive bladder (OAB) affects 12 to 30% of the world's population. The accompanying urinary urgency, frequency and incontinence can have a profound effect on quality of life, leading to depression, social isolation, avoidance of sexual activity and loss of productivity. Conservative measures such as lifestyle modification and pelvic floor physical therapy are the first line of treatment for overactive bladder. Patients who fail these may go on to take medications, undergo neuromodulation or receive injection of botulinum toxin into the bladder wall. While effective, medications have side effects and suffer from poor adherence. Neuromodulation and botulinum toxin injection are also effective but are invasive and not acceptable to some patients. We have developed a novel transcutaneous spinal cord neuromodulator (SCONE™,) that delivers multifrequency electrical stimulation to the spinal cord without the need for insertion or implantation of stimulating electrodes. Previously, multifrequency transcutaneous stimulation has been demonstrated to penetrate to the spinal cord and lead to motor activation of detrusor and external urethral sphincter muscles. Here, we report on eight patients with idiopathic overactive bladder, who underwent 12 weeks of SCONE™ therapy. All patients reported statistically significant clinical improvement in multiple symptoms of overactive bladder, such as urinary urgency, frequency and urge incontinence. In addition, patients reported significant symptomatic improvements as captured by validated clinical surveys. SCONE™ therapy represents the first of its kind therapy to treat symptoms of urgency, frequency and urge urinary incontinence in patients with OAB. The study was listed on clinicaltrials.gov ().
publishDate 2022
dc.date.none.fl_str_mv 2
2022-01-01
2022
2022-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/258895
https://dx.doi.org/urn:doi:10.1186/s42234-022-00087-x
url https://ddd.uab.cat/record/258895
https://dx.doi.org/urn:doi:10.1186/s42234-022-00087-x
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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