Association of exposure to second-hand smoke during childhood with blood DNA methylation
Introduction: By recent estimates, 40% of children worldwide are exposed to second-hand smoke (SHS), which has been associated with adverse health outcomes. While numerous studies have linked maternal smoking during pregnancy (MSDP) to widespread differences in child blood DNA methylation (DNAm), re...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:305839 |
| Acceso en línea: | https://ddd.uab.cat/record/305839 https://dx.doi.org/urn:doi:10.1016/j.envint.2024.109204 |
| Access Level: | acceso abierto |
| Palabra clave: | 450K array Blood DNA methylation Children DNA methylation Maternal smoking during pregnancy Passive smoking Postnatal exposure SDG 3 - Good Health and Well-being |
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España |
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Association of exposure to second-hand smoke during childhood with blood DNA methylation |
| title |
Association of exposure to second-hand smoke during childhood with blood DNA methylation |
| spellingShingle |
Association of exposure to second-hand smoke during childhood with blood DNA methylation Cosin-Tomas, Marta|||0000-0001-5012-8983 450K array Blood DNA methylation Children DNA methylation Maternal smoking during pregnancy Passive smoking Postnatal exposure SDG 3 - Good Health and Well-being |
| title_short |
Association of exposure to second-hand smoke during childhood with blood DNA methylation |
| title_full |
Association of exposure to second-hand smoke during childhood with blood DNA methylation |
| title_fullStr |
Association of exposure to second-hand smoke during childhood with blood DNA methylation |
| title_full_unstemmed |
Association of exposure to second-hand smoke during childhood with blood DNA methylation |
| title_sort |
Association of exposure to second-hand smoke during childhood with blood DNA methylation |
| dc.creator.none.fl_str_mv |
Cosin-Tomas, Marta|||0000-0001-5012-8983 Hoang, Thanh Qi, Cancan Monasso, Giulietta S. Langdon, Ryan Kebede Merid, Simon Calas, Lucinda Prado Bert, Paula de|||0000-0003-1901-5846 Richmond, Rebecca|||0000-0003-0574-5071 Jaddoe, Vincent V. W. Duijts, Liesbeth Wright, John|||0000-0001-9572-7293 Annesi-Maesano, Isabella|||0000-0002-6340-9300 Grazuleviciene, Regina|||0000-0002-0210-8053 Karachaliou, Marianna|||0000-0002-3014-0747 Koppelman, Gerard H.|||0000-0001-8567-3252 Melén, Erik|||0000-0002-8248-0663 Gruzieva, Olena Vrijheid, Martine|||0000-0002-7090-1758 Yousefi, Paul Felix, Janine F.|||0000-0002-9801-5774 London, Stephanie J.|||0000-0003-4911-5290 Bustamante, Mariona|||0000-0003-0127-2860 |
| author |
Cosin-Tomas, Marta|||0000-0001-5012-8983 |
| author_facet |
Cosin-Tomas, Marta|||0000-0001-5012-8983 Hoang, Thanh Qi, Cancan Monasso, Giulietta S. Langdon, Ryan Kebede Merid, Simon Calas, Lucinda Prado Bert, Paula de|||0000-0003-1901-5846 Richmond, Rebecca|||0000-0003-0574-5071 Jaddoe, Vincent V. W. Duijts, Liesbeth Wright, John|||0000-0001-9572-7293 Annesi-Maesano, Isabella|||0000-0002-6340-9300 Grazuleviciene, Regina|||0000-0002-0210-8053 Karachaliou, Marianna|||0000-0002-3014-0747 Koppelman, Gerard H.|||0000-0001-8567-3252 Melén, Erik|||0000-0002-8248-0663 Gruzieva, Olena Vrijheid, Martine|||0000-0002-7090-1758 Yousefi, Paul Felix, Janine F.|||0000-0002-9801-5774 London, Stephanie J.|||0000-0003-4911-5290 Bustamante, Mariona|||0000-0003-0127-2860 |
| author_role |
author |
| author2 |
Hoang, Thanh Qi, Cancan Monasso, Giulietta S. Langdon, Ryan Kebede Merid, Simon Calas, Lucinda Prado Bert, Paula de|||0000-0003-1901-5846 Richmond, Rebecca|||0000-0003-0574-5071 Jaddoe, Vincent V. W. Duijts, Liesbeth Wright, John|||0000-0001-9572-7293 Annesi-Maesano, Isabella|||0000-0002-6340-9300 Grazuleviciene, Regina|||0000-0002-0210-8053 Karachaliou, Marianna|||0000-0002-3014-0747 Koppelman, Gerard H.|||0000-0001-8567-3252 Melén, Erik|||0000-0002-8248-0663 Gruzieva, Olena Vrijheid, Martine|||0000-0002-7090-1758 Yousefi, Paul Felix, Janine F.|||0000-0002-9801-5774 London, Stephanie J.|||0000-0003-4911-5290 Bustamante, Mariona|||0000-0003-0127-2860 |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
450K array Blood DNA methylation Children DNA methylation Maternal smoking during pregnancy Passive smoking Postnatal exposure SDG 3 - Good Health and Well-being |
| topic |
450K array Blood DNA methylation Children DNA methylation Maternal smoking during pregnancy Passive smoking Postnatal exposure SDG 3 - Good Health and Well-being |
| description |
Introduction: By recent estimates, 40% of children worldwide are exposed to second-hand smoke (SHS), which has been associated with adverse health outcomes. While numerous studies have linked maternal smoking during pregnancy (MSDP) to widespread differences in child blood DNA methylation (DNAm), research specifically examining postnatal SHS exposure remains sparse. To address this gap, we conducted epigenome-wide meta-analyses to identify associations of postnatal SHS and child blood DNAm. Methods: Six cohorts from the Pregnancy And Childhood Epigenetics (PACE) Consortium (total N = 2,695), with SHS data and child blood DNAm (aged 7-9 years) measured with the Illumina 450K array were included in the meta-analysis. Linear regression models adjusted for covariates were fitted to examine the association between the number of household smokers in postnatal life (0, 1, 2+) and child blood DNAm. Sensitivity models without adjusting for MSDP and restricted to mothers who did not smoke during pregnancy were evaluated. Results: Our analysis revealed significant associations (False Discovery Rate < 0.05) between household postnatal SHS exposure and DNAm at 11 CpGs in exposed children. Nine CpGs were mapped to genes (MYO1G, FAM184B, CTDSPL2, LTBP3, PDE10A, and FIBCD1), while 2 CpGs were located in open sea regions. Notably, all except 2 CpGs (mapped to FIBCD1 and CTDSPL2) have previously been linked to either personal smoking habits or in utero exposure to smoking. The models restricted to non-smoking mothers provided similar results. Importantly, several of these CpGs and their associated genes are implicated in conditions exacerbated by or directly linked to SHS. Conclusions: Our findings highlight the potential biological effects of SHS on blood DNAm. These findings support further research on epigenetic factors mediating deleterious effects of SHS on child health and call for public health policies aimed at reducing exposure, particularly in environments where children are present. |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2 2025-01-01 2025 2025-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/article |
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article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/305839 https://dx.doi.org/urn:doi:10.1016/j.envint.2024.109204 |
| url |
https://ddd.uab.cat/record/305839 https://dx.doi.org/urn:doi:10.1016/j.envint.2024.109204 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
European Commission https://doi.org/10.13039/501100000780 874583 Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2019/BP-00107 Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 CEX2023-0001290-S European Commission https://doi.org/10.13039/501100000780 733206 European Commission https://doi.org/10.13039/501100000780 874739 |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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Universitat Autònoma de Barcelona |
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Dipòsit Digital de Documents de la UAB |
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1869424277306998784 |
| spelling |
Association of exposure to second-hand smoke during childhood with blood DNA methylationCosin-Tomas, Marta|||0000-0001-5012-8983Hoang, ThanhQi, CancanMonasso, Giulietta S.Langdon, RyanKebede Merid, SimonCalas, LucindaPrado Bert, Paula de|||0000-0003-1901-5846Richmond, Rebecca|||0000-0003-0574-5071Jaddoe, Vincent V. W.Duijts, LiesbethWright, John|||0000-0001-9572-7293Annesi-Maesano, Isabella|||0000-0002-6340-9300Grazuleviciene, Regina|||0000-0002-0210-8053Karachaliou, Marianna|||0000-0002-3014-0747Koppelman, Gerard H.|||0000-0001-8567-3252Melén, Erik|||0000-0002-8248-0663Gruzieva, OlenaVrijheid, Martine|||0000-0002-7090-1758Yousefi, PaulFelix, Janine F.|||0000-0002-9801-5774London, Stephanie J.|||0000-0003-4911-5290Bustamante, Mariona|||0000-0003-0127-2860450K arrayBlood DNA methylationChildrenDNA methylationMaternal smoking during pregnancyPassive smokingPostnatal exposureSDG 3 - Good Health and Well-beingIntroduction: By recent estimates, 40% of children worldwide are exposed to second-hand smoke (SHS), which has been associated with adverse health outcomes. While numerous studies have linked maternal smoking during pregnancy (MSDP) to widespread differences in child blood DNA methylation (DNAm), research specifically examining postnatal SHS exposure remains sparse. To address this gap, we conducted epigenome-wide meta-analyses to identify associations of postnatal SHS and child blood DNAm. Methods: Six cohorts from the Pregnancy And Childhood Epigenetics (PACE) Consortium (total N = 2,695), with SHS data and child blood DNAm (aged 7-9 years) measured with the Illumina 450K array were included in the meta-analysis. Linear regression models adjusted for covariates were fitted to examine the association between the number of household smokers in postnatal life (0, 1, 2+) and child blood DNAm. Sensitivity models without adjusting for MSDP and restricted to mothers who did not smoke during pregnancy were evaluated. Results: Our analysis revealed significant associations (False Discovery Rate < 0.05) between household postnatal SHS exposure and DNAm at 11 CpGs in exposed children. Nine CpGs were mapped to genes (MYO1G, FAM184B, CTDSPL2, LTBP3, PDE10A, and FIBCD1), while 2 CpGs were located in open sea regions. Notably, all except 2 CpGs (mapped to FIBCD1 and CTDSPL2) have previously been linked to either personal smoking habits or in utero exposure to smoking. The models restricted to non-smoking mothers provided similar results. Importantly, several of these CpGs and their associated genes are implicated in conditions exacerbated by or directly linked to SHS. Conclusions: Our findings highlight the potential biological effects of SHS on blood DNAm. These findings support further research on epigenetic factors mediating deleterious effects of SHS on child health and call for public health policies aimed at reducing exposure, particularly in environments where children are present. 22025-01-0120252025-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/305839https://dx.doi.org/urn:doi:10.1016/j.envint.2024.109204reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengEuropean Commission https://doi.org/10.13039/501100000780 874583Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2019/BP-00107Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 CEX2023-0001290-SEuropean Commission https://doi.org/10.13039/501100000780 733206European Commission https://doi.org/10.13039/501100000780 874739open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3058392026-06-06T12:50:31Z |
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15,812429 |