A lncRNA-mediated metabolic rewiring of cell senescence

Metabolism; RNA-binding proteins; Senescence

Detalles Bibliográficos
Autores: Grossi, Elena, Marchese, Francesco, González, Jovanna, Goñi, Enrique, Fernández-Justel, José Miguel, Amadoz, Alicia, Herranz Martín, Nicolás
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:11351/13618
Acceso en línea:http://hdl.handle.net/11351/13618
Access Level:acceso abierto
Palabra clave:Metabolisme
Cèl·lules - Envelliment
RNA
CHEMICALS AND DRUGS::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNA::RNA, Untranslated::RNA, Long Noncoding
PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cellular Senescence
PHENOMENA AND PROCESSES::Metabolism
COMPUESTOS QUÍMICOS Y DROGAS::nucleótidos y nucleósidos de ácidos nucleicos::ácidos nucleicos::ARN::ARN no traducido::ARN largo no codificante
FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::senescencia celular
FENÓMENOS Y PROCESOS::metabolismo
id ES_f25b9d75656c5ae01022096a8a4e0e6d
oai_identifier_str oai:recercat.cat:11351/13618
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv A lncRNA-mediated metabolic rewiring of cell senescence
title A lncRNA-mediated metabolic rewiring of cell senescence
spellingShingle A lncRNA-mediated metabolic rewiring of cell senescence
Grossi, Elena
Metabolisme
Cèl·lules - Envelliment
RNA
CHEMICALS AND DRUGS::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNA::RNA, Untranslated::RNA, Long Noncoding
PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cellular Senescence
PHENOMENA AND PROCESSES::Metabolism
COMPUESTOS QUÍMICOS Y DROGAS::nucleótidos y nucleósidos de ácidos nucleicos::ácidos nucleicos::ARN::ARN no traducido::ARN largo no codificante
FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::senescencia celular
FENÓMENOS Y PROCESOS::metabolismo
title_short A lncRNA-mediated metabolic rewiring of cell senescence
title_full A lncRNA-mediated metabolic rewiring of cell senescence
title_fullStr A lncRNA-mediated metabolic rewiring of cell senescence
title_full_unstemmed A lncRNA-mediated metabolic rewiring of cell senescence
title_sort A lncRNA-mediated metabolic rewiring of cell senescence
dc.creator.none.fl_str_mv Grossi, Elena
Marchese, Francesco
González, Jovanna
Goñi, Enrique
Fernández-Justel, José Miguel
Amadoz, Alicia
Herranz Martín, Nicolás
author Grossi, Elena
author_facet Grossi, Elena
Marchese, Francesco
González, Jovanna
Goñi, Enrique
Fernández-Justel, José Miguel
Amadoz, Alicia
Herranz Martín, Nicolás
author_role author
author2 Marchese, Francesco
González, Jovanna
Goñi, Enrique
Fernández-Justel, José Miguel
Amadoz, Alicia
Herranz Martín, Nicolás
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Grossi E] Center for Applied Medical Research, University of Navarra, Pamplona, Spain. Institute of Health Research of Navarra (IdiSNA), Pamplona, Spain. Departments of Oncological Sciences and Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. [Marchese FP, González J, Goñi E, Fernández-Justel JM, Amadoz A] Center for Applied Medical Research, University of Navarra, Pamplona, Spain. Institute of Health Research of Navarra (IdiSNA), Pamplona, Spain. [Herranz N] Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Metabolisme
Cèl·lules - Envelliment
RNA
CHEMICALS AND DRUGS::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNA::RNA, Untranslated::RNA, Long Noncoding
PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cellular Senescence
PHENOMENA AND PROCESSES::Metabolism
COMPUESTOS QUÍMICOS Y DROGAS::nucleótidos y nucleósidos de ácidos nucleicos::ácidos nucleicos::ARN::ARN no traducido::ARN largo no codificante
FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::senescencia celular
FENÓMENOS Y PROCESOS::metabolismo
topic Metabolisme
Cèl·lules - Envelliment
RNA
CHEMICALS AND DRUGS::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNA::RNA, Untranslated::RNA, Long Noncoding
PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cellular Senescence
PHENOMENA AND PROCESSES::Metabolism
COMPUESTOS QUÍMICOS Y DROGAS::nucleótidos y nucleósidos de ácidos nucleicos::ácidos nucleicos::ARN::ARN no traducido::ARN largo no codificante
FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::senescencia celular
FENÓMENOS Y PROCESOS::metabolismo
description Metabolism; RNA-binding proteins; Senescence
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11351/13618
url http://hdl.handle.net/11351/13618
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Cell Reports;44(6)
https://doi.org/10.1016/j.celrep.2025.115747
dc.rights.none.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Scientia
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869424272344088576
spelling A lncRNA-mediated metabolic rewiring of cell senescenceGrossi, ElenaMarchese, FrancescoGonzález, JovannaGoñi, EnriqueFernández-Justel, José MiguelAmadoz, AliciaHerranz Martín, NicolásMetabolismeCèl·lules - EnvellimentRNACHEMICALS AND DRUGS::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNA::RNA, Untranslated::RNA, Long NoncodingPHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cellular SenescencePHENOMENA AND PROCESSES::MetabolismCOMPUESTOS QUÍMICOS Y DROGAS::nucleótidos y nucleósidos de ácidos nucleicos::ácidos nucleicos::ARN::ARN no traducido::ARN largo no codificanteFENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::senescencia celularFENÓMENOS Y PROCESOS::metabolismoMetabolism; RNA-binding proteins; SenescenceMetabolisme; Proteïnes d'unió a ARN; SenescènciaMetabolismo; Proteínas de unión a ARN; SenescenciaDespite not proliferating, senescent cells remain metabolically active to maintain the senescence program. However, the mechanisms behind this metabolic reprogramming are not well understood. We identify senescence-induced long noncoding RNA (sin-lncRNA), a previously uncharacterized long noncoding RNA (lncRNA), a key player in this response. While strongly activated in senescence by C/EBPβ, sin-lncRNA loss reinforces the senescence program by altering oxidative phosphorylation and rewiring mitochondrial metabolism. By interacting with dihydrolipoamide S-succinyltransferase (DLST), it facilitates its mitochondrial localization. Depletion of sin-lncRNA causes DLST nuclear translocation, leading to transcriptional changes in oxidative phosphorylation (OXPHOS) genes. While not expressed in highly proliferative cancer cells, it is strongly induced upon cisplatin-induced senescence. Depletion of sin-lncRNA in ovarian cancer cells reduces oxygen consumption and increases extracellular acidification, sensitizing cells to cisplatin treatment. Altogether, these results indicate that sin-lncRNA is specifically induced in senescence to maintain metabolic homeostasis, unveiling an RNA-dependent metabolic rewiring specific to senescent cells.We thank Eva Santamaría for her input and help with the Seahorse experiments. We thank Beatriz Tavira (CIMA, Universidad de Navarra) for providing the COD362 cells. We thank Sebastiaan Martijn Van Liempd and Juan Manuel Falcón (Metabolomic Platform, CIC bioGUNE) and Lorea Válcarcel (UPV) and Arkaitz Carracerdo (CIC bioGUNE) for their input on the metabolic experiments. We thank Lukas Bethlehem for helping interpreting the metabolomic data. We thank Victor Segura and Eli Guruceaga for the guilt-by-association analysis. We thank Jesus Gil (MRC, London) for his input. We acknowledge the ENCODE project and The Cancer Genome Atlas database for their valuable datasets. We thank the rest of the Huarte lab for contributing with helpful discussions. The work was supported by Project PID2023-147980NB-100 financed by MICIU/AEI/10.13039/501100011033 and FEDER, UE , 'La Caixa' Foundation (LCF/PR/HR21/00176), Worldwide Cancer Research grant 25-0335, and Ayuda Proyectos Generales AECC 2024. M.M. was funded by an MSCA fellowship (HORIZON-MSCA- 2021-PF-01: 101066499) and currently by Ministerio de Ciencia e Innovación through Programa Ramón y Cajal (RYC2022-036819-I) . L.P.-C. is supported by Instituto de Salud Carlos III (Ministerio de Ciencia e Innovación) through a Miguel Servet contract (CP22/00005), co-funded by the European Union.ElsevierInstitut Català de la Salut[Grossi E] Center for Applied Medical Research, University of Navarra, Pamplona, Spain. Institute of Health Research of Navarra (IdiSNA), Pamplona, Spain. Departments of Oncological Sciences and Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. [Marchese FP, González J, Goñi E, Fernández-Justel JM, Amadoz A] Center for Applied Medical Research, University of Navarra, Pamplona, Spain. Institute of Health Research of Navarra (IdiSNA), Pamplona, Spain. [Herranz N] Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202520252025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/11351/13618Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésCell Reports;44(6)https://doi.org/10.1016/j.celrep.2025.115747Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/136182026-05-29T05:05:01Z
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