Dietary Zinc and Risk of Prostate Cancer in Spain: MCC-Spain Study

Zinc is a key trace element in normal prostate cell metabolism, and is decreased in neoplastic cells. However, the association between dietary zinc and prostate cancer (PC) in epidemiologic studies is a conflicting one. Our aim was to explore this association in an MCC-Spain case-control study, cons...

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Autores: Gutiérrez González, Enrique, Castelló, Adela, Fernández Navarro, Pablo, Alguacil Ojeda, Juan
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universidad de Huelva (UHU)
Repositorio:Arias Montano. Repositorio Institucional de la Universidad de Huelva
Idioma:inglés
OAI Identifier:oai:ariasmontano.uhu.es:10272/16399
Acceso en línea:http://hdl.handle.net/10272/16399
Access Level:acceso abierto
Palabra clave:Dietary zinc
Prostate cancer
Diet
Genetic susceptibility
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spelling Dietary Zinc and Risk of Prostate Cancer in Spain: MCC-Spain StudyGutiérrez González, EnriqueCastelló, AdelaFernández Navarro, PabloAlguacil Ojeda, JuanDietary zincProstate cancerDietGenetic susceptibilityZinc is a key trace element in normal prostate cell metabolism, and is decreased in neoplastic cells. However, the association between dietary zinc and prostate cancer (PC) in epidemiologic studies is a conflicting one. Our aim was to explore this association in an MCC-Spain case-control study, considering tumor aggressiveness and extension, as well as genetic susceptibility to PC. 733 incident cases and 1228 population-based controls were included for this study. Dietary zinc was assessed using a food frequency questionnaire, and genetic susceptibility was assessed with a single nucleotide polymorphisms (SNP)-based polygenic risk score (PRS). The association between zinc intake and PC was evaluated with mixed logistic and multinomial regression models. They showed an increased risk of PC in those with higher intake of zinc (Odds Ratio (OR) tertile 3vs1: 1.39; 95% Confidence interval (CI):1.00–1.95). This association was mainly observed in low grade PC (Gleason = 6 RRR tertile 3vs1: 1.76; 95% CI:1.18–2.63) as well as in localized tumors (cT1-cT2a RRR tertile 3vs1: 1.40; 95% CI:1.00–1.95) and among those with higher PRS (OR tertile 3vs1: 1.50; 95% CI:0.89–2.53). In conclusion, a higher dietary zinc intake could increase the risk of low grade and localized tumors. Men with higher genetic susceptibility might also have a higher risk of PC associated with this nutrient intake.MDPI20182018-12-0120182018-12-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10272/16399reponame:Arias Montano. Repositorio Institucional de la Universidad de Huelvainstname:Universidad de Huelva (UHU)InglésengSpanish Ministry of Economy and Competitiveness Juan de la Cierva de Incorporacion IJCI-2014-20900 Not available Not availableConsejeria de Salud of the Junta de Andalucia 2009-S0143 Not available Not availableopen accesshttp://purl.org/coar/access_right/c_abf2Atribución-NoComercial-SinDerivadas 3.0 Españahttp://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:ariasmontano.uhu.es:10272/163992026-06-02T14:58:11Z
dc.title.none.fl_str_mv Dietary Zinc and Risk of Prostate Cancer in Spain: MCC-Spain Study
title Dietary Zinc and Risk of Prostate Cancer in Spain: MCC-Spain Study
spellingShingle Dietary Zinc and Risk of Prostate Cancer in Spain: MCC-Spain Study
Gutiérrez González, Enrique
Dietary zinc
Prostate cancer
Diet
Genetic susceptibility
title_short Dietary Zinc and Risk of Prostate Cancer in Spain: MCC-Spain Study
title_full Dietary Zinc and Risk of Prostate Cancer in Spain: MCC-Spain Study
title_fullStr Dietary Zinc and Risk of Prostate Cancer in Spain: MCC-Spain Study
title_full_unstemmed Dietary Zinc and Risk of Prostate Cancer in Spain: MCC-Spain Study
title_sort Dietary Zinc and Risk of Prostate Cancer in Spain: MCC-Spain Study
dc.creator.none.fl_str_mv Gutiérrez González, Enrique
Castelló, Adela
Fernández Navarro, Pablo
Alguacil Ojeda, Juan
author Gutiérrez González, Enrique
author_facet Gutiérrez González, Enrique
Castelló, Adela
Fernández Navarro, Pablo
Alguacil Ojeda, Juan
author_role author
author2 Castelló, Adela
Fernández Navarro, Pablo
Alguacil Ojeda, Juan
author2_role author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Dietary zinc
Prostate cancer
Diet
Genetic susceptibility
topic Dietary zinc
Prostate cancer
Diet
Genetic susceptibility
description Zinc is a key trace element in normal prostate cell metabolism, and is decreased in neoplastic cells. However, the association between dietary zinc and prostate cancer (PC) in epidemiologic studies is a conflicting one. Our aim was to explore this association in an MCC-Spain case-control study, considering tumor aggressiveness and extension, as well as genetic susceptibility to PC. 733 incident cases and 1228 population-based controls were included for this study. Dietary zinc was assessed using a food frequency questionnaire, and genetic susceptibility was assessed with a single nucleotide polymorphisms (SNP)-based polygenic risk score (PRS). The association between zinc intake and PC was evaluated with mixed logistic and multinomial regression models. They showed an increased risk of PC in those with higher intake of zinc (Odds Ratio (OR) tertile 3vs1: 1.39; 95% Confidence interval (CI):1.00–1.95). This association was mainly observed in low grade PC (Gleason = 6 RRR tertile 3vs1: 1.76; 95% CI:1.18–2.63) as well as in localized tumors (cT1-cT2a RRR tertile 3vs1: 1.40; 95% CI:1.00–1.95) and among those with higher PRS (OR tertile 3vs1: 1.50; 95% CI:0.89–2.53). In conclusion, a higher dietary zinc intake could increase the risk of low grade and localized tumors. Men with higher genetic susceptibility might also have a higher risk of PC associated with this nutrient intake.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-12-01
2018
2018-12-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10272/16399
url http://hdl.handle.net/10272/16399
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Spanish Ministry of Economy and Competitiveness Juan de la Cierva de Incorporacion IJCI-2014-20900 Not available Not available
Consejeria de Salud of the Junta de Andalucia 2009-S0143 Not available Not available
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial-SinDerivadas 3.0 España
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Arias Montano. Repositorio Institucional de la Universidad de Huelva
instname:Universidad de Huelva (UHU)
instname_str Universidad de Huelva (UHU)
reponame_str Arias Montano. Repositorio Institucional de la Universidad de Huelva
collection Arias Montano. Repositorio Institucional de la Universidad de Huelva
repository.name.fl_str_mv
repository.mail.fl_str_mv
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