Long-term anatomical and functional outcomes after autokeratoplasty

Background: To evaluate the anatomical and functional outcomes of autologous contralateral penetrating keratoplasty (autokeratoplasty). Methods: Kaplan-Meier survival analyses were retrospectively performed. Anatomical failure was defined as regraft or graft permanently cloudy at any time during fol...

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Autores: Sanjuán, Pablo, Julio, Gemma, Bolaños, Jennifer, De Toledo, Juan Álvarez, García de Oteyza, Gonzalo, Temprano, José, Barraquer, Rafael Ignacio
Formato: artículo
Fecha de publicación:2021
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:20.500.12328/3916
Acesso em linha:http://hdl.handle.net/20.500.12328/3916
https://dx.doi.org/10.1136/bjophthalmol-2020-316289
Access Level:acceso abierto
Palavra-chave:Oftalmologia
Oftalmología
Ophtalmology
617
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repository_id_str
spelling Long-term anatomical and functional outcomes after autokeratoplastySanjuán, PabloJulio, GemmaBolaños, JenniferDe Toledo, Juan ÁlvarezGarcía de Oteyza, GonzaloTemprano, JoséBarraquer, Rafael IgnacioOftalmologiaOftalmologíaOphtalmology617Background: To evaluate the anatomical and functional outcomes of autologous contralateral penetrating keratoplasty (autokeratoplasty). Methods: Kaplan-Meier survival analyses were retrospectively performed. Anatomical failure was defined as regraft or graft permanently cloudy at any time during follow-up. Functional failure was defined as the final best-corrected visual acuity (BCVA) <20/400. Results: Thirty-one eyes of 31 patients (19 men), with a mean age of 52±18 years (range 15–81 years) were studied during a mean follow-up of 11.3 years (from 13 months to 48 years). At 12 months postoperatively, all the recipient eyes showed a transparent cornea, but 23% showed functional failure. At the final followup, 16 recipient eyes (52%) showed anatomical and functional success. Twenty-three eyes (74%) showed a clear cornea and 68% reached a better BCVA when compared with preoperative measurements. Nevertheless, 13/31 eyes (42%) displayed functional failure. The accumulative probabilities for anatomical success were 100%, 72% and 48% and 77%, 59% and 29% for functional success at 1, 10 and 40 years, respectively. The most common risk factor for failure was progression of previous glaucoma in 50% of the anatomical failures and in 77% of the functional failures. Conclusions: Autokeratoplasty could be a successful long-term option in patients having one eye with a clear cornea but with irreversible visual dysfunction and the contralateral eye having favourable visual potential limited only by a completely opacified cornea. Progression of previous glaucoma was the most important risk factor for long-term cornea decompensation and visual functional failure in the sample.info:eu-repo/semantics/publishedVersionBMJ Publishing Group2021info:eu-repo/semantics/article5http://hdl.handle.net/20.500.12328/3916https://dx.doi.org/10.1136/bjophthalmol-2020-316289reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésBritish Journal of Ophthalmology105© Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.info:eu-repo/semantics/openAccessoai:recercat.cat:20.500.12328/39162026-05-29T05:05:01Z
dc.title.none.fl_str_mv Long-term anatomical and functional outcomes after autokeratoplasty
title Long-term anatomical and functional outcomes after autokeratoplasty
spellingShingle Long-term anatomical and functional outcomes after autokeratoplasty
Sanjuán, Pablo
Oftalmologia
Oftalmología
Ophtalmology
617
title_short Long-term anatomical and functional outcomes after autokeratoplasty
title_full Long-term anatomical and functional outcomes after autokeratoplasty
title_fullStr Long-term anatomical and functional outcomes after autokeratoplasty
title_full_unstemmed Long-term anatomical and functional outcomes after autokeratoplasty
title_sort Long-term anatomical and functional outcomes after autokeratoplasty
dc.creator.none.fl_str_mv Sanjuán, Pablo
Julio, Gemma
Bolaños, Jennifer
De Toledo, Juan Álvarez
García de Oteyza, Gonzalo
Temprano, José
Barraquer, Rafael Ignacio
author Sanjuán, Pablo
author_facet Sanjuán, Pablo
Julio, Gemma
Bolaños, Jennifer
De Toledo, Juan Álvarez
García de Oteyza, Gonzalo
Temprano, José
Barraquer, Rafael Ignacio
author_role author
author2 Julio, Gemma
Bolaños, Jennifer
De Toledo, Juan Álvarez
García de Oteyza, Gonzalo
Temprano, José
Barraquer, Rafael Ignacio
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Oftalmologia
Oftalmología
Ophtalmology
617
topic Oftalmologia
Oftalmología
Ophtalmology
617
description Background: To evaluate the anatomical and functional outcomes of autologous contralateral penetrating keratoplasty (autokeratoplasty). Methods: Kaplan-Meier survival analyses were retrospectively performed. Anatomical failure was defined as regraft or graft permanently cloudy at any time during follow-up. Functional failure was defined as the final best-corrected visual acuity (BCVA) <20/400. Results: Thirty-one eyes of 31 patients (19 men), with a mean age of 52±18 years (range 15–81 years) were studied during a mean follow-up of 11.3 years (from 13 months to 48 years). At 12 months postoperatively, all the recipient eyes showed a transparent cornea, but 23% showed functional failure. At the final followup, 16 recipient eyes (52%) showed anatomical and functional success. Twenty-three eyes (74%) showed a clear cornea and 68% reached a better BCVA when compared with preoperative measurements. Nevertheless, 13/31 eyes (42%) displayed functional failure. The accumulative probabilities for anatomical success were 100%, 72% and 48% and 77%, 59% and 29% for functional success at 1, 10 and 40 years, respectively. The most common risk factor for failure was progression of previous glaucoma in 50% of the anatomical failures and in 77% of the functional failures. Conclusions: Autokeratoplasty could be a successful long-term option in patients having one eye with a clear cornea but with irreversible visual dysfunction and the contralateral eye having favourable visual potential limited only by a completely opacified cornea. Progression of previous glaucoma was the most important risk factor for long-term cornea decompensation and visual functional failure in the sample.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12328/3916
https://dx.doi.org/10.1136/bjophthalmol-2020-316289
url http://hdl.handle.net/20.500.12328/3916
https://dx.doi.org/10.1136/bjophthalmol-2020-316289
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv British Journal of Ophthalmology
105
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 5
dc.publisher.none.fl_str_mv BMJ Publishing Group
publisher.none.fl_str_mv BMJ Publishing Group
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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