Thermosensitive hydrogels to deliver reactive species generated by cold atmospheric plasma: a case study with methylcellulose

Hydrogels have been recently proposed as suitable materials to generate reactive oxygen and nitrogen species (RONS) upon gas-plasma treatment, and postulated as promising alternatives to conventional cancer therapies. Acting as delivery vehicles that allow a controlled release of RONS to the disease...

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Autores: Solé-Martí X, Vilella T, Labay C, Tampieri F, Ginebra MP, Canal C
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p21702
Acceso en línea:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=21702
Access Level:acceso abierto
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spelling Thermosensitive hydrogels to deliver reactive species generated by cold atmospheric plasma: a case study with methylcelluloseSolé-Martí XVilella TLabay CTampieri FGinebra MPCanal CHydrogels have been recently proposed as suitable materials to generate reactive oxygen and nitrogen species (RONS) upon gas-plasma treatment, and postulated as promising alternatives to conventional cancer therapies. Acting as delivery vehicles that allow a controlled release of RONS to the diseased site, plasma-treated hydrogels can overcome some of the limitations presented by plasma-treated liquids in in vivo therapies. In this work, we optimized the composition of a methylcellulose (MC) hydrogel to confer it with the ability to form a gel at physiological temperatures while remaining in the liquid phase at room temperature to allow gas-plasma treatment with suitable formation of plasma-generated RONS. MC hydrogels demonstrated the capacity for generation, prolonged storage and release of RONS. This release induced cytotoxic effects on the osteosarcoma cancer cell line MG-63, reducing its cell viability in a dose-response manner. These promising results postulate plasma-treated thermosensitive hydrogels as good candidates to provide local anticancer therapies.ROYAL SOC CHEMISTRY2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=21702Biomaterials ScienceISSN: 20474830ISSNe: 20474849reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p217022026-05-27T12:37:41Z
dc.title.none.fl_str_mv Thermosensitive hydrogels to deliver reactive species generated by cold atmospheric plasma: a case study with methylcellulose
title Thermosensitive hydrogels to deliver reactive species generated by cold atmospheric plasma: a case study with methylcellulose
spellingShingle Thermosensitive hydrogels to deliver reactive species generated by cold atmospheric plasma: a case study with methylcellulose
Solé-Martí X
title_short Thermosensitive hydrogels to deliver reactive species generated by cold atmospheric plasma: a case study with methylcellulose
title_full Thermosensitive hydrogels to deliver reactive species generated by cold atmospheric plasma: a case study with methylcellulose
title_fullStr Thermosensitive hydrogels to deliver reactive species generated by cold atmospheric plasma: a case study with methylcellulose
title_full_unstemmed Thermosensitive hydrogels to deliver reactive species generated by cold atmospheric plasma: a case study with methylcellulose
title_sort Thermosensitive hydrogels to deliver reactive species generated by cold atmospheric plasma: a case study with methylcellulose
dc.creator.none.fl_str_mv Solé-Martí X
Vilella T
Labay C
Tampieri F
Ginebra MP
Canal C
author Solé-Martí X
author_facet Solé-Martí X
Vilella T
Labay C
Tampieri F
Ginebra MP
Canal C
author_role author
author2 Vilella T
Labay C
Tampieri F
Ginebra MP
Canal C
author2_role author
author
author
author
author
description Hydrogels have been recently proposed as suitable materials to generate reactive oxygen and nitrogen species (RONS) upon gas-plasma treatment, and postulated as promising alternatives to conventional cancer therapies. Acting as delivery vehicles that allow a controlled release of RONS to the diseased site, plasma-treated hydrogels can overcome some of the limitations presented by plasma-treated liquids in in vivo therapies. In this work, we optimized the composition of a methylcellulose (MC) hydrogel to confer it with the ability to form a gel at physiological temperatures while remaining in the liquid phase at room temperature to allow gas-plasma treatment with suitable formation of plasma-generated RONS. MC hydrogels demonstrated the capacity for generation, prolonged storage and release of RONS. This release induced cytotoxic effects on the osteosarcoma cancer cell line MG-63, reducing its cell viability in a dose-response manner. These promising results postulate plasma-treated thermosensitive hydrogels as good candidates to provide local anticancer therapies.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=21702
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=21702
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ROYAL SOC CHEMISTRY
publisher.none.fl_str_mv ROYAL SOC CHEMISTRY
dc.source.none.fl_str_mv Biomaterials Science
ISSN: 20474830
ISSNe: 20474849
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
repository.name.fl_str_mv
repository.mail.fl_str_mv
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