Cancer stem cells and epithelial-to-mesenchymal transition in cancer metastasis

Data de publicació electrónica: 30-09-2019

Detalles Bibliográficos
Autores: Celià-Terrassa, Toni, Jolly, Mohit Kumar
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/44473
Acceso en línea:http://hdl.handle.net/10230/44473
http://dx.doi.org/10.1101/cshperspect.a036905
Access Level:acceso abierto
Palabra clave:Metàstasi -- Aspectes genètics
Metàstasi limfàtica
Càncer -- Aspectes genètics
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spelling Cancer stem cells and epithelial-to-mesenchymal transition in cancer metastasisCelià-Terrassa, ToniJolly, Mohit KumarMetàstasi -- Aspectes genèticsMetàstasi limfàticaCàncer -- Aspectes genèticsData de publicació electrónica: 30-09-2019The cancer stem cell (CSC) concept stands for undifferentiated tumor cells with the ability to initiate heterogeneous tumors. It is also relevant in metastasis and can explain how metastatic tumors mirror the heterogeneity of primary tumors. Cellular plasticity, including the epithelial-to-mesenchymal transition (EMT), enables the generation of CSCs at different steps of the metastatic process including metastatic colonization. In this review, we update the concept of CSCs and provide evidence of the existence of metastatic stem cells (MetSCs). In addition, we highlight the nuanced understanding of EMT that has been gained recently and the association of mesenchymal-to-epithelial transition (MET) with the acquisition of CSCs properties during metastasis. We also comment on the computational approaches that have profoundly influenced our understanding of CSCs and EMT; and how these studies and new experimental technologies can yield a deeper understanding of the biological aspects of metastasis.Cold Spring Harbor Laboratory Press (CSHL Press)202020202020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/44473http://dx.doi.org/10.1101/cshperspect.a036905reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésPublished originally by Cold Spring Harbor Laboratory Press at 10.1101/cshperspect.a036905. Beginning six months from the full-issue publication date, articles are distributed under the Creative Commons Attribution-Non-Commercial 4.0 International License (CC-BY-NC), as described at http://creativecommons.org/licenses/by-nc/4.0/. This license permits non-commercial use, including reproduction, adaptation, and distribution of the article provided the original author and source are credited.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/444732026-05-29T05:05:01Z
dc.title.none.fl_str_mv Cancer stem cells and epithelial-to-mesenchymal transition in cancer metastasis
title Cancer stem cells and epithelial-to-mesenchymal transition in cancer metastasis
spellingShingle Cancer stem cells and epithelial-to-mesenchymal transition in cancer metastasis
Celià-Terrassa, Toni
Metàstasi -- Aspectes genètics
Metàstasi limfàtica
Càncer -- Aspectes genètics
title_short Cancer stem cells and epithelial-to-mesenchymal transition in cancer metastasis
title_full Cancer stem cells and epithelial-to-mesenchymal transition in cancer metastasis
title_fullStr Cancer stem cells and epithelial-to-mesenchymal transition in cancer metastasis
title_full_unstemmed Cancer stem cells and epithelial-to-mesenchymal transition in cancer metastasis
title_sort Cancer stem cells and epithelial-to-mesenchymal transition in cancer metastasis
dc.creator.none.fl_str_mv Celià-Terrassa, Toni
Jolly, Mohit Kumar
author Celià-Terrassa, Toni
author_facet Celià-Terrassa, Toni
Jolly, Mohit Kumar
author_role author
author2 Jolly, Mohit Kumar
author2_role author
dc.subject.none.fl_str_mv Metàstasi -- Aspectes genètics
Metàstasi limfàtica
Càncer -- Aspectes genètics
topic Metàstasi -- Aspectes genètics
Metàstasi limfàtica
Càncer -- Aspectes genètics
description Data de publicació electrónica: 30-09-2019
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/44473
http://dx.doi.org/10.1101/cshperspect.a036905
url http://hdl.handle.net/10230/44473
http://dx.doi.org/10.1101/cshperspect.a036905
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cold Spring Harbor Laboratory Press (CSHL Press)
publisher.none.fl_str_mv Cold Spring Harbor Laboratory Press (CSHL Press)
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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