Myo1f, an Unconventional Long-Tailed Myosin, Is a New Partner for the Adaptor 3BP2 Involved in Mast Cell Migration
KIT signaling; Adaptor molecules; Cell migration and adhesion
| Autores: | , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | Departament de Salut de la Generalitat de Catalunya (DS) |
| Repositorio: | Scientia. Dipòsit d'Informació Digital del Departament de Salut |
| OAI Identifier: | oai:scientiasalut.gencat.cat:11351/4257 |
| Acceso en línea: | https://hdl.handle.net/11351/4257 |
| Access Level: | acceso abierto |
| Palabra clave: | Cèl·lules - Motilitat Miosina Proteïnes portadores PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cell Movement Other subheadings::Other subheadings::/physiology CHEMICALS AND DRUGS::Macromolecular Substances::Polymers::Biopolymers::Microfilament Proteins::Myosins::Myosin Type I CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Amino Acids, Peptides, and Proteins::Proteins::Carrier Proteins::Amino Acids, Peptides, and Proteins::Proteins::Adaptor Proteins, Signal Transducing FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::movimiento celular Otros calificadores::Otros calificadores::/fisiología COMPUESTOS QUÍMICOS Y DROGAS::sustancias macromoleculares::polímeros::biopolímeros::proteínas de los microfilamentos::miosinas::miosina de tipo I COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::péptidos::péptidos y proteínas de señalización intracelular::proteínas adaptadoras transductoras de señales |
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| dc.title.none.fl_str_mv |
Myo1f, an Unconventional Long-Tailed Myosin, Is a New Partner for the Adaptor 3BP2 Involved in Mast Cell Migration |
| title |
Myo1f, an Unconventional Long-Tailed Myosin, Is a New Partner for the Adaptor 3BP2 Involved in Mast Cell Migration |
| spellingShingle |
Myo1f, an Unconventional Long-Tailed Myosin, Is a New Partner for the Adaptor 3BP2 Involved in Mast Cell Migration Navinés-Ferrer, Arnau Cèl·lules - Motilitat Miosina Proteïnes portadores PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cell Movement Other subheadings::Other subheadings::/physiology CHEMICALS AND DRUGS::Macromolecular Substances::Polymers::Biopolymers::Microfilament Proteins::Myosins::Myosin Type I CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Amino Acids, Peptides, and Proteins::Proteins::Carrier Proteins::Amino Acids, Peptides, and Proteins::Proteins::Adaptor Proteins, Signal Transducing FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::movimiento celular Otros calificadores::Otros calificadores::/fisiología COMPUESTOS QUÍMICOS Y DROGAS::sustancias macromoleculares::polímeros::biopolímeros::proteínas de los microfilamentos::miosinas::miosina de tipo I COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::péptidos::péptidos y proteínas de señalización intracelular::proteínas adaptadoras transductoras de señales |
| title_short |
Myo1f, an Unconventional Long-Tailed Myosin, Is a New Partner for the Adaptor 3BP2 Involved in Mast Cell Migration |
| title_full |
Myo1f, an Unconventional Long-Tailed Myosin, Is a New Partner for the Adaptor 3BP2 Involved in Mast Cell Migration |
| title_fullStr |
Myo1f, an Unconventional Long-Tailed Myosin, Is a New Partner for the Adaptor 3BP2 Involved in Mast Cell Migration |
| title_full_unstemmed |
Myo1f, an Unconventional Long-Tailed Myosin, Is a New Partner for the Adaptor 3BP2 Involved in Mast Cell Migration |
| title_sort |
Myo1f, an Unconventional Long-Tailed Myosin, Is a New Partner for the Adaptor 3BP2 Involved in Mast Cell Migration |
| dc.creator.none.fl_str_mv |
Navinés-Ferrer, Arnau Ainsua-Enrich, Erola Serrano-Candelas, Eva Sayos Ortega, Juan Martin, Margarita |
| author |
Navinés-Ferrer, Arnau |
| author_facet |
Navinés-Ferrer, Arnau Ainsua-Enrich, Erola Serrano-Candelas, Eva Sayos Ortega, Juan Martin, Margarita |
| author_role |
author |
| author2 |
Ainsua-Enrich, Erola Serrano-Candelas, Eva Sayos Ortega, Juan Martin, Margarita |
| author2_role |
author author author author |
| dc.contributor.none.fl_str_mv |
Institut Català de la Salut [Navinés-Ferrer A, Ainsua-Enrich E, Serrano-Candelas E, Martin M] Unitat de Bioquimica, Departament de Biomedicina, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain. Laboratori de Immunoal•lèrgia Respiratòria Clínica i Experimental, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain. [Sayós J] Regulació Immunològica i Immunoteràpia, CIBBIM-Nanomedicina, Vall d’Hebron Institut de Recerca, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain. Vall d'Hebron Barcelona Hospital Campus |
| dc.subject.none.fl_str_mv |
Cèl·lules - Motilitat Miosina Proteïnes portadores PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cell Movement Other subheadings::Other subheadings::/physiology CHEMICALS AND DRUGS::Macromolecular Substances::Polymers::Biopolymers::Microfilament Proteins::Myosins::Myosin Type I CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Amino Acids, Peptides, and Proteins::Proteins::Carrier Proteins::Amino Acids, Peptides, and Proteins::Proteins::Adaptor Proteins, Signal Transducing FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::movimiento celular Otros calificadores::Otros calificadores::/fisiología COMPUESTOS QUÍMICOS Y DROGAS::sustancias macromoleculares::polímeros::biopolímeros::proteínas de los microfilamentos::miosinas::miosina de tipo I COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::péptidos::péptidos y proteínas de señalización intracelular::proteínas adaptadoras transductoras de señales |
| topic |
Cèl·lules - Motilitat Miosina Proteïnes portadores PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cell Movement Other subheadings::Other subheadings::/physiology CHEMICALS AND DRUGS::Macromolecular Substances::Polymers::Biopolymers::Microfilament Proteins::Myosins::Myosin Type I CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Amino Acids, Peptides, and Proteins::Proteins::Carrier Proteins::Amino Acids, Peptides, and Proteins::Proteins::Adaptor Proteins, Signal Transducing FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::movimiento celular Otros calificadores::Otros calificadores::/fisiología COMPUESTOS QUÍMICOS Y DROGAS::sustancias macromoleculares::polímeros::biopolímeros::proteínas de los microfilamentos::miosinas::miosina de tipo I COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::péptidos::péptidos y proteínas de señalización intracelular::proteínas adaptadoras transductoras de señales |
| description |
KIT signaling; Adaptor molecules; Cell migration and adhesion |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019 2019 2019 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/11351/4257 |
| url |
https://hdl.handle.net/11351/4257 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Frontiers in Immunology;10 https://www.frontiersin.org/articles/10.3389/fimmu.2019.01058/full |
| dc.rights.none.fl_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Frontiers Media |
| publisher.none.fl_str_mv |
Frontiers Media |
| dc.source.none.fl_str_mv |
Scientia reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut instname:Departament de Salut de la Generalitat de Catalunya (DS) |
| instname_str |
Departament de Salut de la Generalitat de Catalunya (DS) |
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Scientia. Dipòsit d'Informació Digital del Departament de Salut |
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Scientia. Dipòsit d'Informació Digital del Departament de Salut |
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| _version_ |
1869424229470961664 |
| spelling |
Myo1f, an Unconventional Long-Tailed Myosin, Is a New Partner for the Adaptor 3BP2 Involved in Mast Cell MigrationNavinés-Ferrer, ArnauAinsua-Enrich, ErolaSerrano-Candelas, EvaSayos Ortega, JuanMartin, MargaritaCèl·lules - MotilitatMiosinaProteïnes portadoresPHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cell MovementOther subheadings::Other subheadings::/physiologyCHEMICALS AND DRUGS::Macromolecular Substances::Polymers::Biopolymers::Microfilament Proteins::Myosins::Myosin Type ICHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Amino Acids, Peptides, and Proteins::Proteins::Carrier Proteins::Amino Acids, Peptides, and Proteins::Proteins::Adaptor Proteins, Signal TransducingFENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::movimiento celularOtros calificadores::Otros calificadores::/fisiologíaCOMPUESTOS QUÍMICOS Y DROGAS::sustancias macromoleculares::polímeros::biopolímeros::proteínas de los microfilamentos::miosinas::miosina de tipo ICOMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::péptidos::péptidos y proteínas de señalización intracelular::proteínas adaptadoras transductoras de señalesKIT signaling; Adaptor molecules; Cell migration and adhesionSenyalització KIT; Molècules adaptadores; Migració i adhesió cel·lularSeñalización KIT; Moléculas adaptadoras; Migración y adhesión celularMast cell chemotaxis is essential for cell recruitment to target tissues, where these cells play an important role in adaptive and innate immunity. Stem cell factor (SCF) is a major chemoattractant for mast cells. SCF binds to the KIT receptor, thereby triggering tyrosine phosphorylation in the cytoplasmic domain and resulting in docking sites for SH2 domain-containing molecules, such as Lyn and Fyn, and the subsequent activation of the small GTPases Rac that are responsible for cytoskeletal reorganization and mast cell migration. In previous works we have reported the role of 3BP2, an adaptor molecule, in mast cells. 3BP2 silencing reduces FcεRI-dependent degranulation, by targeting Lyn and Syk phosphorylation, as well as SCF-dependent cell survival. This study examines its role in SCF-dependent migration and reveals that 3BP2 silencing in human mast cell line (LAD2) impairs cell migration due to SCF and IgE. In that context we found that 3BP2 silencing decreases Rac-2 and Cdc42 GTPase activity. Furthermore, we identified Myo1f, an unconventional type-I myosin, as a new partner for 3BP2. This protein, whose functions have been described as critical for neutrophil migration, remained elusive in mast cells. Myo1f is expressed in mast cells and colocalizes with cortical actin ring. Interestingly, Myo1f-3BP2 interaction is modulated by KIT signaling. Moreover, SCF dependent adhesion and migration through fibronectin is decreased after Myo1f silencing. Furthermore, Myo1f silencing leads to downregulation of β1 and β7 integrins on the mast cell membrane. Overall, Myo1f is a new 3BP2 ligand that connects the adaptor to actin cytoskeleton and both molecules are involved in SCF dependent mast cell migration.Frontiers MediaInstitut Català de la Salut[Navinés-Ferrer A, Ainsua-Enrich E, Serrano-Candelas E, Martin M] Unitat de Bioquimica, Departament de Biomedicina, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain. Laboratori de Immunoal•lèrgia Respiratòria Clínica i Experimental, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain. [Sayós J] Regulació Immunològica i Immunoteràpia, CIBBIM-Nanomedicina, Vall d’Hebron Institut de Recerca, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain.Vall d'Hebron Barcelona Hospital Campus201920192019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/4257Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésFrontiers in Immunology;10https://www.frontiersin.org/articles/10.3389/fimmu.2019.01058/fullAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/42572026-06-12T09:38:37Z |
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15.811543 |