The Role of Exercise-Based Cardiac Rehabilitation After Myocardial Infarction on Cholesterol Transfer to HDL

High-density lipoprotein (HDL) is associated with decreased incidence of cardiovascular events, and its functionality also influences prognosis. Exercise is an important tool to improve prognosis in the post-infarction (MI) population, but the role of exercise on HDL functionality is poorly understo...

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Detalles Bibliográficos
Autores: Nicolau, José C., Dalcoquio, Talia F., Giraldez, Roberto R., Freitas, Fatima R., Nicolau, Andre M., Furtado, Remo H. M., Tavoni, Thauany M., Baracioli, Luciano M., Lima, Felipe G., Ferrari, Aline G., Rondon, Maria U. P. B., Salsoso, Rocío, Alves, María J. N. N., Arantes, Flavia B. B., Santos, Mayara A., Alves, Leandro S., Negrao, Carlos E., Maranhão, Raul C.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/390375
Acceso en línea:http://hdl.handle.net/10261/390375
https://api.elsevier.com/content/abstract/scopus_id/85214467665
Access Level:acceso abierto
Palabra clave:HDL functionality
Acute myocardial infarction
Cardiac rehabilitation
Supervised exercise
Descripción
Sumario:High-density lipoprotein (HDL) is associated with decreased incidence of cardiovascular events, and its functionality also influences prognosis. Exercise is an important tool to improve prognosis in the post-infarction (MI) population, but the role of exercise on HDL functionality is poorly understood. Sixty-two patients with acute MI were randomized in a supervised exercise program for 12-14 weeks (exercise group-EG) or a control group (CG). The main objective of the study was to analyze the role of exercise on esterified cholesterol (EC) and unesterified cholesterol (UC) transfer to HDL. For the total population, the baseline mean rate of EC transfer to HDL was 2.53 ± 0.83 and at the end of follow-up, it was 2.74 ± 0.64 (p = 0.03). The figures for UC were, respectively, 4.08 ± 1.2 and 4.4 ± 1.06 (p = 0.02). The difference (follow-up minus baseline) for EC was 0.15 ± 0.84 for the control group and 0.27 ± 0.69 for the exercise group (p = 0.53); for UC, the figures were 0.28 ± 1.14 and 0.35 ± 0.96 (p = 0.80), respectively, for the control and exercise groups. In post-MI patients, 12-14 weeks of supervised exercise did not improve HDL functionality.

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