Highly-Bioreactive Silica-Based Mesoporous Bioactive Glasses Enriched with Gallium(III)

Beneficial effects in bone cell growth and antibacterial action are currently attributed to Ga3+ ions. Thus, they can be used to upgrade mesoporous bioactive glasses (MBGs), investigated for tissue engineering, whenever they released therapeutic amounts of gallium ions to the surrounding medium. Thr...

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Detalles Bibliográficos
Autores: Sánchez Salcedo, Sandra, Malavasi, Gianluca, Salinas Sánchez, Antonio Jesús, Lusvardi, Gigliola, Rigamonti, Luca, Menabue, Ledi, Vallet Regí, María Dulce Nombre
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/12709
Acceso en línea:https://hdl.handle.net/20.500.14352/12709
Access Level:acceso abierto
Palabra clave:615.4
Gallium ions
Mesoporous glasses
Glass structure
In vitro bioactivity
Antibacterial capability
Química farmaceútica
2390 Química Farmacéutica
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repository_id_str
spelling Highly-Bioreactive Silica-Based Mesoporous Bioactive Glasses Enriched with Gallium(III)Sánchez Salcedo, SandraMalavasi, GianlucaSalinas Sánchez, Antonio JesúsLusvardi, GigliolaRigamonti, LucaMenabue, LediVallet Regí, María Dulce Nombre615.4Gallium ionsMesoporous glassesGlass structureIn vitro bioactivityAntibacterial capabilityQuímica farmaceútica2390 Química FarmacéuticaBeneficial effects in bone cell growth and antibacterial action are currently attributed to Ga3+ ions. Thus, they can be used to upgrade mesoporous bioactive glasses (MBGs), investigated for tissue engineering, whenever they released therapeutic amounts of gallium ions to the surrounding medium. Three gallium-enriched MBGs with composition (in mol %) xSiO2–yCaO–zP2O5–5Ga2O3, being x = 70, y = 15, z = 10 for Ga_1; x = 80, y = 12, z = 3 for Ga_2; and x = 80, y = 15, z = 0 for Ga_3, were investigated and compared with the gallium-free 80SiO2–15CaO–5P2O5 MBG (B). 29Si and 31P MAS NMR analyses indicated that Ga3+ acts as network modifier in the glass regions with higher polymerization degree and as network former in the zones with high concentration of classical modifiers (Ca2+ ions). Ga_1 and Ga_2 exhibited a quick in vitro bioactive response because they were coated by an apatite-like layer after 1 and 3 days in simulated body fluid. Although we have not conducted biological tests in this paper (cells or bacteria), Ga_1 released high but non-cytotoxic amounts of Ga3+ ions in Todd Hewitt Broth culture medium that were 140 times higher than the IC90 of Pseudomonas aeruginosa bacteria, demonstrating its potential for tissue engineering applications.MDPIUniversidad Complutense de Madrid20182018-03-0220182018-03-02journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/12709reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/127092026-06-02T12:44:21Z
dc.title.none.fl_str_mv Highly-Bioreactive Silica-Based Mesoporous Bioactive Glasses Enriched with Gallium(III)
title Highly-Bioreactive Silica-Based Mesoporous Bioactive Glasses Enriched with Gallium(III)
spellingShingle Highly-Bioreactive Silica-Based Mesoporous Bioactive Glasses Enriched with Gallium(III)
Sánchez Salcedo, Sandra
615.4
Gallium ions
Mesoporous glasses
Glass structure
In vitro bioactivity
Antibacterial capability
Química farmaceútica
2390 Química Farmacéutica
title_short Highly-Bioreactive Silica-Based Mesoporous Bioactive Glasses Enriched with Gallium(III)
title_full Highly-Bioreactive Silica-Based Mesoporous Bioactive Glasses Enriched with Gallium(III)
title_fullStr Highly-Bioreactive Silica-Based Mesoporous Bioactive Glasses Enriched with Gallium(III)
title_full_unstemmed Highly-Bioreactive Silica-Based Mesoporous Bioactive Glasses Enriched with Gallium(III)
title_sort Highly-Bioreactive Silica-Based Mesoporous Bioactive Glasses Enriched with Gallium(III)
dc.creator.none.fl_str_mv Sánchez Salcedo, Sandra
Malavasi, Gianluca
Salinas Sánchez, Antonio Jesús
Lusvardi, Gigliola
Rigamonti, Luca
Menabue, Ledi
Vallet Regí, María Dulce Nombre
author Sánchez Salcedo, Sandra
author_facet Sánchez Salcedo, Sandra
Malavasi, Gianluca
Salinas Sánchez, Antonio Jesús
Lusvardi, Gigliola
Rigamonti, Luca
Menabue, Ledi
Vallet Regí, María Dulce Nombre
author_role author
author2 Malavasi, Gianluca
Salinas Sánchez, Antonio Jesús
Lusvardi, Gigliola
Rigamonti, Luca
Menabue, Ledi
Vallet Regí, María Dulce Nombre
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 615.4
Gallium ions
Mesoporous glasses
Glass structure
In vitro bioactivity
Antibacterial capability
Química farmaceútica
2390 Química Farmacéutica
topic 615.4
Gallium ions
Mesoporous glasses
Glass structure
In vitro bioactivity
Antibacterial capability
Química farmaceútica
2390 Química Farmacéutica
description Beneficial effects in bone cell growth and antibacterial action are currently attributed to Ga3+ ions. Thus, they can be used to upgrade mesoporous bioactive glasses (MBGs), investigated for tissue engineering, whenever they released therapeutic amounts of gallium ions to the surrounding medium. Three gallium-enriched MBGs with composition (in mol %) xSiO2–yCaO–zP2O5–5Ga2O3, being x = 70, y = 15, z = 10 for Ga_1; x = 80, y = 12, z = 3 for Ga_2; and x = 80, y = 15, z = 0 for Ga_3, were investigated and compared with the gallium-free 80SiO2–15CaO–5P2O5 MBG (B). 29Si and 31P MAS NMR analyses indicated that Ga3+ acts as network modifier in the glass regions with higher polymerization degree and as network former in the zones with high concentration of classical modifiers (Ca2+ ions). Ga_1 and Ga_2 exhibited a quick in vitro bioactive response because they were coated by an apatite-like layer after 1 and 3 days in simulated body fluid. Although we have not conducted biological tests in this paper (cells or bacteria), Ga_1 released high but non-cytotoxic amounts of Ga3+ ions in Todd Hewitt Broth culture medium that were 140 times higher than the IC90 of Pseudomonas aeruginosa bacteria, demonstrating its potential for tissue engineering applications.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-03-02
2018
2018-03-02
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/12709
url https://hdl.handle.net/20.500.14352/12709
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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