Association between circulating irisin levels and the promotion of insulin resistance during the weight maintenance period after a dietary weight-lowering program in obese patients

OBJECTIVE: Weight regain is associated with the promotion of insulin resistance. The newly discovered myokine irisin, which was proposed to be involved in the management of insulin sensitivity, could play a role in this process. This study aimed to investigate the association between irisin and redu...

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Autores: Crujeiras Martínez, Ana Belén, Zulet, M. A., Lopez-Legarrea, P., de la Iglesia, R., Pardo, M., Carreira Delgado, Manuel Carlos, Martínez, J. A., Casanueva Freijo, Felipe
Formato: artículo
Fecha de publicación:2014
País:España
Recursos:Servizo Galego de Saúde (SERGAS)
Repositorio:RUNA. Repositorio da Consellería de Sanidade e Sergas
OAI Identifier:oai:runa.sergas.gal:20.500.11940/4553
Acesso em linha:http://hdl.handle.net/20.500.11940/4553
Access Level:acceso abierto
Palavra-chave:Adiponectin
Adult
Female
Fibronectins
Ghrelin
Humans
Insulin Resistance
Leptin
Male
Middle Aged
Obesity
Tumor Necrosis Factor-alpha/blood
Weight Loss
Fndc5
Hypocaloric diet
Insulin sensitivity
Weight regain
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oai_identifier_str oai:runa.sergas.gal:20.500.11940/4553
network_acronym_str ES
network_name_str España
repository_id_str
spelling Association between circulating irisin levels and the promotion of insulin resistance during the weight maintenance period after a dietary weight-lowering program in obese patientsCrujeiras Martínez, Ana BelénZulet, M. A.Lopez-Legarrea, P.de la Iglesia, R.Pardo, M.Carreira Delgado, Manuel CarlosMartínez, J. A.Casanueva Freijo, FelipeAdiponectinAdultFemaleFibronectinsGhrelinHumansInsulin ResistanceLeptinMaleMiddle AgedObesityTumor Necrosis Factor-alpha/bloodWeight LossFndc5Hypocaloric dietInsulin sensitivityWeight regainOBJECTIVE: Weight regain is associated with the promotion of insulin resistance. The newly discovered myokine irisin, which was proposed to be involved in the management of insulin sensitivity, could play a role in this process. This study aimed to investigate the association between irisin and reduced insulin sensitivity induced by weight regain. MATERIALS/METHODS: Insulin sensitivity was evaluated according to the homeostasis model assessment of insulin resistance (HOMA-IR) in 136 obese patients who followed an eight-week hypocaloric diet (30% reduced energy expenditure) to lose weight and was re-evaluated four or six months after treatment. Irisin plasma levels, as well as the levels of leptin, adiponectin, ghrelin and TNF-alpha, were quantified in a sub-cohort (n=73) from the initially studied patients at baseline (T0), at the diet endpoint (T1) and after the follow-up period (T2). RESULTS: After a successful dietary intervention to lose weight, 50% of the patients who regained the lost weight during the follow-up period were categorized as insulin resistant (HOMA-IR>/=2.5) compared with only 25% of patients who maintained the weight loss (p=0.018). Importantly, in addition to the well-studied hormones leptin and adiponectin, irisin plasma levels were statistically associated with several risk factors for insulin resistance. Indeed, the increased risk of insulin resistance during the follow-up period was related to high irisin levels at baseline (odds ratio=4.2; p=0.039). CONCLUSIONS: Circulating irisin predicts the insulin resistance onset in association with weight regain. Therefore, irisin could be secreted as an adaptive response to counteract the deleterious effect of excess adiposity on glucose homeostasis.2014info:eu-repo/semantics/articlehttp://hdl.handle.net/20.500.11940/4553reponame:RUNA. Repositorio da Consellería de Sanidade e Sergasinstname:Servizo Galego de Saúde (SERGAS)Inglésinfo:eu-repo/semantics/openAccessoai:runa.sergas.gal:20.500.11940/45532026-06-12T08:40:47Z
dc.title.none.fl_str_mv Association between circulating irisin levels and the promotion of insulin resistance during the weight maintenance period after a dietary weight-lowering program in obese patients
title Association between circulating irisin levels and the promotion of insulin resistance during the weight maintenance period after a dietary weight-lowering program in obese patients
spellingShingle Association between circulating irisin levels and the promotion of insulin resistance during the weight maintenance period after a dietary weight-lowering program in obese patients
Crujeiras Martínez, Ana Belén
Adiponectin
Adult
Female
Fibronectins
Ghrelin
Humans
Insulin Resistance
Leptin
Male
Middle Aged
Obesity
Tumor Necrosis Factor-alpha/blood
Weight Loss
Fndc5
Hypocaloric diet
Insulin sensitivity
Weight regain
title_short Association between circulating irisin levels and the promotion of insulin resistance during the weight maintenance period after a dietary weight-lowering program in obese patients
title_full Association between circulating irisin levels and the promotion of insulin resistance during the weight maintenance period after a dietary weight-lowering program in obese patients
title_fullStr Association between circulating irisin levels and the promotion of insulin resistance during the weight maintenance period after a dietary weight-lowering program in obese patients
title_full_unstemmed Association between circulating irisin levels and the promotion of insulin resistance during the weight maintenance period after a dietary weight-lowering program in obese patients
title_sort Association between circulating irisin levels and the promotion of insulin resistance during the weight maintenance period after a dietary weight-lowering program in obese patients
dc.creator.none.fl_str_mv Crujeiras Martínez, Ana Belén
Zulet, M. A.
Lopez-Legarrea, P.
de la Iglesia, R.
Pardo, M.
Carreira Delgado, Manuel Carlos
Martínez, J. A.
Casanueva Freijo, Felipe
author Crujeiras Martínez, Ana Belén
author_facet Crujeiras Martínez, Ana Belén
Zulet, M. A.
Lopez-Legarrea, P.
de la Iglesia, R.
Pardo, M.
Carreira Delgado, Manuel Carlos
Martínez, J. A.
Casanueva Freijo, Felipe
author_role author
author2 Zulet, M. A.
Lopez-Legarrea, P.
de la Iglesia, R.
Pardo, M.
Carreira Delgado, Manuel Carlos
Martínez, J. A.
Casanueva Freijo, Felipe
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Adiponectin
Adult
Female
Fibronectins
Ghrelin
Humans
Insulin Resistance
Leptin
Male
Middle Aged
Obesity
Tumor Necrosis Factor-alpha/blood
Weight Loss
Fndc5
Hypocaloric diet
Insulin sensitivity
Weight regain
topic Adiponectin
Adult
Female
Fibronectins
Ghrelin
Humans
Insulin Resistance
Leptin
Male
Middle Aged
Obesity
Tumor Necrosis Factor-alpha/blood
Weight Loss
Fndc5
Hypocaloric diet
Insulin sensitivity
Weight regain
description OBJECTIVE: Weight regain is associated with the promotion of insulin resistance. The newly discovered myokine irisin, which was proposed to be involved in the management of insulin sensitivity, could play a role in this process. This study aimed to investigate the association between irisin and reduced insulin sensitivity induced by weight regain. MATERIALS/METHODS: Insulin sensitivity was evaluated according to the homeostasis model assessment of insulin resistance (HOMA-IR) in 136 obese patients who followed an eight-week hypocaloric diet (30% reduced energy expenditure) to lose weight and was re-evaluated four or six months after treatment. Irisin plasma levels, as well as the levels of leptin, adiponectin, ghrelin and TNF-alpha, were quantified in a sub-cohort (n=73) from the initially studied patients at baseline (T0), at the diet endpoint (T1) and after the follow-up period (T2). RESULTS: After a successful dietary intervention to lose weight, 50% of the patients who regained the lost weight during the follow-up period were categorized as insulin resistant (HOMA-IR>/=2.5) compared with only 25% of patients who maintained the weight loss (p=0.018). Importantly, in addition to the well-studied hormones leptin and adiponectin, irisin plasma levels were statistically associated with several risk factors for insulin resistance. Indeed, the increased risk of insulin resistance during the follow-up period was related to high irisin levels at baseline (odds ratio=4.2; p=0.039). CONCLUSIONS: Circulating irisin predicts the insulin resistance onset in association with weight regain. Therefore, irisin could be secreted as an adaptive response to counteract the deleterious effect of excess adiposity on glucose homeostasis.
publishDate 2014
dc.date.none.fl_str_mv 2014
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.11940/4553
url http://hdl.handle.net/20.500.11940/4553
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:RUNA. Repositorio da Consellería de Sanidade e Sergas
instname:Servizo Galego de Saúde (SERGAS)
instname_str Servizo Galego de Saúde (SERGAS)
reponame_str RUNA. Repositorio da Consellería de Sanidade e Sergas
collection RUNA. Repositorio da Consellería de Sanidade e Sergas
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301629

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