Extraintestinal Manifestations in Patients with Inflammatory Bowel Disease: Study Based on the ENEIDA Registry

Background Patients with inflammatory bowel disease (IBD) may present extraintestinal manifestations (EIMs) that affect the joints, skin, eyes, and hepatobiliary area, among others. Aims Our aim was to analyse the prevalence and characteristics of EIMs in patients with IBD and to identify the possib...

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Bibliographic Details
Authors: Algaba, A, Guerra, I, Ricart, E, Iglesias, E, Manosa, M, Gisbert, JP, Guardiola, J, Minguez, M, Castro, B, de Francisco, R, Nos, P, Bertoletti, F, Mesonero, F, Barrio, J, Martin-Arranz, MD, Calvet, X, Garcia-Lopez, S, Sicilia, B, Alcain, G, Esteve, M, Marquez, L, Piqueras, M, Jimenez, L, Perez-Calle, JL, Bujanda, L, Garcia-Sepulcre, M, Fernandez, A, Moraleja, I, Lorente, RH, Garcia-Bosch, O, Lamban, A, Blazquez, I, Rodriguez, E, Huguet, JM, Lucendo, AJ, Almela, P, Busquets, D, de la Piscina, PR, Perez, M, Domenech, E, Bermejo, F, Spanish GETECCU Grp, ENEIDA Project
Format: article
Status:Published version
Publication Date:2021
Country:España
Institution:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repository:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p8793
Online Access:https://fisabio.portalinvestigacion.com/publicaciones/8793
Access Level:Open access
Keyword:Inflammatory bowel disease
Rheumatic diseases
Skin manifestations
Eye manifestations
Sclerosing cholangitis
Description
Summary:Background Patients with inflammatory bowel disease (IBD) may present extraintestinal manifestations (EIMs) that affect the joints, skin, eyes, and hepatobiliary area, among others. Aims Our aim was to analyse the prevalence and characteristics of EIMs in patients with IBD and to identify the possible risk factors associated with the development of EIMs in the largest series published to date. Methods Observational, cross-sectional study including patients from the Spanish ENEIDA registry promoted by GETECCU. We retrospectively identified all cases of EIMs in the ENEIDA registry until January 2018. Results The study included 31,077 patients, 5779 of whom had at least one EIM (global prevalence 19%; 95% CI 18.2-19.0). Among the different types of EIMs, rheumatic manifestations had a prevalence of 13% (95% CI 12.9-13.7; 63% of EIMs), with a prevalence of 5% (95% CI 4.7-5.2) for mucocutaneous manifestations, 2.1% (95% CI 1.9-2.2) for ocular manifestations, and 0.7% (95% CI 0.6-0.8) for hepatobiliary manifestations. The multivariable analysis showed that the type of IBD (Crohn's disease,p < 0.001), gender (female,p < 0.001), the need for an immunomodulator (p < 0.001) or biologic drugs (p < 0.001), a previous family history of IBD (p < 0.001), and an extensive location of IBD (p < 0.001) were risk factors for the presence of EIMs. Conclusions One-fifth of patients with IBD may have associated EIMs, with rheumatic manifestations as the most frequent (> 60% of EIMs). Female patients with severe Crohn's disease represent the group with the highest risk of developing EIMs. These patients should therefore be specially monitored and referred to the corresponding specialist when suggestive symptoms appear.

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