Mitochondrial dynamics and mitophagy in skeletal muscle health and aging

The maintenance of mitochondrial integrity is critical for muscle health. Mitochondria, indeed, play vital roles in a wide range of cellular processes, including energy supply, Ca2+ homeostasis, retrograde signaling, cell death, and many others. All mitochondria-containing cells, including skeletal...

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Detalles Bibliográficos
Autores: Leduc-Gaudet, Jean-Philippe, Hussain, Sabah N.A., Barreiro Portela, Esther, Gouspillou, Gilles
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/53507
Acceso en línea:http://hdl.handle.net/10230/53507
http://dx.doi.org/10.3390/ijms22158179
Access Level:acceso abierto
Palabra clave:Aging
Autophagy
Mitochondrial dynamics
Mitophagy
Sarcopenia
Skeletal muscle
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spelling Mitochondrial dynamics and mitophagy in skeletal muscle health and agingLeduc-Gaudet, Jean-PhilippeHussain, Sabah N.A.Barreiro Portela, EstherGouspillou, GillesAgingAutophagyMitochondrial dynamicsMitophagySarcopeniaSkeletal muscleThe maintenance of mitochondrial integrity is critical for muscle health. Mitochondria, indeed, play vital roles in a wide range of cellular processes, including energy supply, Ca2+ homeostasis, retrograde signaling, cell death, and many others. All mitochondria-containing cells, including skeletal muscle cells, dispose of several pathways to maintain mitochondrial health, including mitochondrial biogenesis, mitochondrial-derived vesicles, mitochondrial dynamics (fusion and fission process shaping mitochondrial morphology), and mitophagy-the process in charge of the removal of mitochondria though autophagy. The loss of skeletal muscle mass (atrophy) is a major health problem worldwide, especially in older people. Currently, there is no treatment to counteract the progressive decline in skeletal muscle mass and strength that occurs with aging, a process termed sarcopenia. There is increasing data, including our own, suggesting that accumulation of dysfunctional mitochondria contributes to the development of sarcopenia. Impairments in mitochondrial dynamics and mitophagy were recently proposed to contribute to sarcopenia. This review summarizes the current state of knowledge on the role played by mitochondrial dynamics and mitophagy in skeletal muscle health and in the development of sarcopenia. We also highlight recent studies showing that enhancing mitophagy in skeletal muscle is a promising therapeutic target to prevent or even treat skeletal muscle dysfunction in the elderly.MDPI202220222021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/53507http://dx.doi.org/10.3390/ijms22158179reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésCopyright © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/535072026-05-29T05:05:01Z
dc.title.none.fl_str_mv Mitochondrial dynamics and mitophagy in skeletal muscle health and aging
title Mitochondrial dynamics and mitophagy in skeletal muscle health and aging
spellingShingle Mitochondrial dynamics and mitophagy in skeletal muscle health and aging
Leduc-Gaudet, Jean-Philippe
Aging
Autophagy
Mitochondrial dynamics
Mitophagy
Sarcopenia
Skeletal muscle
title_short Mitochondrial dynamics and mitophagy in skeletal muscle health and aging
title_full Mitochondrial dynamics and mitophagy in skeletal muscle health and aging
title_fullStr Mitochondrial dynamics and mitophagy in skeletal muscle health and aging
title_full_unstemmed Mitochondrial dynamics and mitophagy in skeletal muscle health and aging
title_sort Mitochondrial dynamics and mitophagy in skeletal muscle health and aging
dc.creator.none.fl_str_mv Leduc-Gaudet, Jean-Philippe
Hussain, Sabah N.A.
Barreiro Portela, Esther
Gouspillou, Gilles
author Leduc-Gaudet, Jean-Philippe
author_facet Leduc-Gaudet, Jean-Philippe
Hussain, Sabah N.A.
Barreiro Portela, Esther
Gouspillou, Gilles
author_role author
author2 Hussain, Sabah N.A.
Barreiro Portela, Esther
Gouspillou, Gilles
author2_role author
author
author
dc.subject.none.fl_str_mv Aging
Autophagy
Mitochondrial dynamics
Mitophagy
Sarcopenia
Skeletal muscle
topic Aging
Autophagy
Mitochondrial dynamics
Mitophagy
Sarcopenia
Skeletal muscle
description The maintenance of mitochondrial integrity is critical for muscle health. Mitochondria, indeed, play vital roles in a wide range of cellular processes, including energy supply, Ca2+ homeostasis, retrograde signaling, cell death, and many others. All mitochondria-containing cells, including skeletal muscle cells, dispose of several pathways to maintain mitochondrial health, including mitochondrial biogenesis, mitochondrial-derived vesicles, mitochondrial dynamics (fusion and fission process shaping mitochondrial morphology), and mitophagy-the process in charge of the removal of mitochondria though autophagy. The loss of skeletal muscle mass (atrophy) is a major health problem worldwide, especially in older people. Currently, there is no treatment to counteract the progressive decline in skeletal muscle mass and strength that occurs with aging, a process termed sarcopenia. There is increasing data, including our own, suggesting that accumulation of dysfunctional mitochondria contributes to the development of sarcopenia. Impairments in mitochondrial dynamics and mitophagy were recently proposed to contribute to sarcopenia. This review summarizes the current state of knowledge on the role played by mitochondrial dynamics and mitophagy in skeletal muscle health and in the development of sarcopenia. We also highlight recent studies showing that enhancing mitophagy in skeletal muscle is a promising therapeutic target to prevent or even treat skeletal muscle dysfunction in the elderly.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/53507
http://dx.doi.org/10.3390/ijms22158179
url http://hdl.handle.net/10230/53507
http://dx.doi.org/10.3390/ijms22158179
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
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