New transcription regulatory mechanisms of latent HIV LTR

Despite the effectiveness of antiretroviral medication, the HIV virus persists in resting memory T cells of infected patients in a latent state, providing the main impediment to eradication of the virus. We are interested in identifying the molecular mechanism responsible for the establishment and m...

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Detalles Bibliográficos
Autores: Rafati, Haleh, Moshkin, Yuri, Mahmoudi, Tokameh, Parra Bola, Mª Isabel, Hakre, Shweta, Verdin, Eric
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2012
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/126526
Acceso en línea:https://hdl.handle.net/2445/126526
Access Level:acceso abierto
Palabra clave:VIH (Virus)
Antiretrovirals
HIV (Viruses)
Antiretroviral agents
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spelling New transcription regulatory mechanisms of latent HIV LTRRafati, HalehMoshkin, YuriMahmoudi, TokamehParra Bola, Mª IsabelHakre, ShwetaVerdin, EricVIH (Virus)AntiretroviralsHIV (Viruses)Antiretroviral agentsDespite the effectiveness of antiretroviral medication, the HIV virus persists in resting memory T cells of infected patients in a latent state, providing the main impediment to eradication of the virus. We are interested in identifying the molecular mechanism responsible for the establishment and maintenance of HIV latency and its re-activation. We recently used a cell system reflecting HIV latency in my lab to determine the high resolution nucleosomal landscape of the latent HIV LTR and examine its dynamic changes upon re-activation (Rafati et al., Nov 2011 PLoS Biology)...BioMed Central2012info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/126526Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1186/1742-4690-9-S1-O3Retrovirology, 2012, vol. 9, supl. 1, num. O3https://doi.org/10.1186/1742-4690-9-S1-O3cc by (c) Rafati et al., 2012http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1265262026-05-27T06:46:51Z
dc.title.none.fl_str_mv New transcription regulatory mechanisms of latent HIV LTR
title New transcription regulatory mechanisms of latent HIV LTR
spellingShingle New transcription regulatory mechanisms of latent HIV LTR
Rafati, Haleh
VIH (Virus)
Antiretrovirals
HIV (Viruses)
Antiretroviral agents
title_short New transcription regulatory mechanisms of latent HIV LTR
title_full New transcription regulatory mechanisms of latent HIV LTR
title_fullStr New transcription regulatory mechanisms of latent HIV LTR
title_full_unstemmed New transcription regulatory mechanisms of latent HIV LTR
title_sort New transcription regulatory mechanisms of latent HIV LTR
dc.creator.none.fl_str_mv Rafati, Haleh
Moshkin, Yuri
Mahmoudi, Tokameh
Parra Bola, Mª Isabel
Hakre, Shweta
Verdin, Eric
author Rafati, Haleh
author_facet Rafati, Haleh
Moshkin, Yuri
Mahmoudi, Tokameh
Parra Bola, Mª Isabel
Hakre, Shweta
Verdin, Eric
author_role author
author2 Moshkin, Yuri
Mahmoudi, Tokameh
Parra Bola, Mª Isabel
Hakre, Shweta
Verdin, Eric
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv VIH (Virus)
Antiretrovirals
HIV (Viruses)
Antiretroviral agents
topic VIH (Virus)
Antiretrovirals
HIV (Viruses)
Antiretroviral agents
description Despite the effectiveness of antiretroviral medication, the HIV virus persists in resting memory T cells of infected patients in a latent state, providing the main impediment to eradication of the virus. We are interested in identifying the molecular mechanism responsible for the establishment and maintenance of HIV latency and its re-activation. We recently used a cell system reflecting HIV latency in my lab to determine the high resolution nucleosomal landscape of the latent HIV LTR and examine its dynamic changes upon re-activation (Rafati et al., Nov 2011 PLoS Biology)...
publishDate 2012
dc.date.none.fl_str_mv 2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/126526
url https://hdl.handle.net/2445/126526
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1186/1742-4690-9-S1-O3
Retrovirology, 2012, vol. 9, supl. 1, num. O3
https://doi.org/10.1186/1742-4690-9-S1-O3
dc.rights.none.fl_str_mv cc by (c) Rafati et al., 2012
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Rafati et al., 2012
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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