Toward new engagement paradigms for intraocular lenses: Light-initiated bonding of capsular bag to lens materials

8 págs.; 5 figs.

Detalles Bibliográficos
Autores: Marcos, Susana, Alejandre, Nicolás, Lamela, Jorge, Dorronsoro, Carlos, Kochevar, I.E.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/134935
Acceso en línea:http://hdl.handle.net/10261/134935
Access Level:acceso abierto
Palabra clave:Lens capsule
Physiological optics
Photobonding
A-IOLs
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spelling Toward new engagement paradigms for intraocular lenses: Light-initiated bonding of capsular bag to lens materialsMarcos, SusanaAlejandre, NicolásLamela, JorgeDorronsoro, CarlosKochevar, I.E.Lens capsulePhysiological opticsPhotobondingA-IOLs8 págs.; 5 figs.© 2015 The Association for Research in Vision and Ophthalmology, Inc. PURPOSE. Successful intraocular lens procedures, that is, implantation of accommodating intraocular lenses (A-IOL), require firm engagement of the IOL haptics to the capsular bag. We evaluated the use of photochemical bonding to engage IOL materials to the capsular bag. METHODS. Freshly enucleated eyes of New Zealand rabbits were used in two types of photobonding experiments using Rose Bengal (RB) photoinitiation and green light (532-nm) irradiation. First, RB-stained capsular bag strips were photobonded ex vivo to IOL polymer [poly(2-hydroxyethyl methacrylate) pHEMA] strips in an atmosphere of air and of nitrogen. Second, IOLs were implanted intracapsularly and photobonded intraocularly. Irradiation times were between 30 and 180 seconds, and laser irradiance was between 0.25 and 0.65 W/cm2. The strength of the bonding was tested using a custom-developed uniaxial extensiometry system and the breakage load (the load that caused breakage per bonded area) was calculated. RESULTS. The breakage load of ex vivo capsule–pHEMA bonds increased exponentially with irradiation time, using 0.45 W/cm2. In air, the average breakage load across all conditions was 1 g/mm2 and 1.6 times lower than that in a nitrogen atmosphere. Intraocularly, RB-stained IOLs were strongly photobonded to the capsule bag with breakage loads > 0.8 g/mm2. CONCLUSIONS. Breakage of the photobonded linkage between IOL material and capsular bag required loads substantially greater than the maximum force of ciliary muscle, suggesting that this technology may introduce a new paradigm for engagement of A-IOLs. The bonding produced in air was stronger than that in nitrogen atmosphere, suggesting that oxygen is involved in the chemical mechanism for photobonding.Supported by European Research Council (ERC) EU Seventh Framework Program (FP/2007-2013)/ERC grant agreement, ERC- 2011-AdC 294099 (SM), Spanish Government Grants FIS2011- 25637 (SM) and FIS2013-49544-EXP (CD), and Juan de la Cierva postdoctoral fellowship (JL).Peer ReviewedMinisterio de Ciencia e Innovación (España)Ministerio de Economía y Competitividad (España)European Research CouncilConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2016201620152016info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/134935reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/FP7/294099info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/FIS2013-49544-EXPhttp://dx.doi.org/10.1167/iovs.15-17070Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1349352026-05-22T06:33:51Z
dc.title.none.fl_str_mv Toward new engagement paradigms for intraocular lenses: Light-initiated bonding of capsular bag to lens materials
title Toward new engagement paradigms for intraocular lenses: Light-initiated bonding of capsular bag to lens materials
spellingShingle Toward new engagement paradigms for intraocular lenses: Light-initiated bonding of capsular bag to lens materials
Marcos, Susana
Lens capsule
Physiological optics
Photobonding
A-IOLs
title_short Toward new engagement paradigms for intraocular lenses: Light-initiated bonding of capsular bag to lens materials
title_full Toward new engagement paradigms for intraocular lenses: Light-initiated bonding of capsular bag to lens materials
title_fullStr Toward new engagement paradigms for intraocular lenses: Light-initiated bonding of capsular bag to lens materials
title_full_unstemmed Toward new engagement paradigms for intraocular lenses: Light-initiated bonding of capsular bag to lens materials
title_sort Toward new engagement paradigms for intraocular lenses: Light-initiated bonding of capsular bag to lens materials
dc.creator.none.fl_str_mv Marcos, Susana
Alejandre, Nicolás
Lamela, Jorge
Dorronsoro, Carlos
Kochevar, I.E.
author Marcos, Susana
author_facet Marcos, Susana
Alejandre, Nicolás
Lamela, Jorge
Dorronsoro, Carlos
Kochevar, I.E.
author_role author
author2 Alejandre, Nicolás
Lamela, Jorge
Dorronsoro, Carlos
Kochevar, I.E.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (España)
Ministerio de Economía y Competitividad (España)
European Research Council
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Lens capsule
Physiological optics
Photobonding
A-IOLs
topic Lens capsule
Physiological optics
Photobonding
A-IOLs
description 8 págs.; 5 figs.
publishDate 2015
dc.date.none.fl_str_mv 2015
2016
2016
2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/134935
url http://hdl.handle.net/10261/134935
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/EC/FP7/294099
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/FIS2013-49544-EXP
http://dx.doi.org/10.1167/iovs.15-17070
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
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