Transmissibility, hospitalization, and intensive care admissions due to omicron compared to delta variants of SARS-CoV-2 in Catalonia: A cohort study and ecological analysis

The transmissibility of omicron using variant screening data from primary care practices (PCP) and hospital admissions. In addition, we used this data from PCP to establish the two periods when delta and omicron were, respectively, dominant (above 95% of cases). After that, we performed a population...

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Detalhes bibliográficos
Autores: Català Sabaté, Martí|||0000-0003-3308-9905, Coma, Ermengol, Alonso Muñoz, Sergio|||0000-0002-3989-8757, Andres Lacueva, Cristina, Blanco, Ignacio, Antón, Andrés, Escales Bordoy, Antoni, Cardona Iglesias, Pere Joan|||0000-0001-5623-7873, Fina Avilés, Francesc, Martró Català, Elisa, Medina, Manuel, Moras Planes, Núria, Saludes Montoro, Verònica, Prats Soler, Clara|||0000-0002-1398-7559, Prieto Alhambra, Daniel, Álvarez Lacalle, Enrique|||0000-0001-6824-6857
Formato: artículo
Fecha de publicación:2022
País:España
Recursos:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/372256
Acesso em linha:https://hdl.handle.net/2117/372256
https://dx.doi.org/10.3389/fpubh.2022.961030
Access Level:acceso abierto
Palavra-chave:COVID-19 (Disease)
COVID-19
Severity
Ecological study
COVID-19 (Malaltia) (Catalunya)
Àrees temàtiques de la UPC::Matemàtiques i estadística::Anàlisi numèrica::Modelització matemàtica
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network_name_str España
repository_id_str
spelling Transmissibility, hospitalization, and intensive care admissions due to omicron compared to delta variants of SARS-CoV-2 in Catalonia: A cohort study and ecological analysisCatalà Sabaté, Martí|||0000-0003-3308-9905Coma, ErmengolAlonso Muñoz, Sergio|||0000-0002-3989-8757Andres Lacueva, CristinaBlanco, IgnacioAntón, AndrésEscales Bordoy, AntoniCardona Iglesias, Pere Joan|||0000-0001-5623-7873Fina Avilés, FrancescMartró Català, ElisaMedina, ManuelMoras Planes, NúriaSaludes Montoro, VerònicaPrats Soler, Clara|||0000-0002-1398-7559Prieto Alhambra, DanielÁlvarez Lacalle, Enrique|||0000-0001-6824-6857COVID-19 (Disease)COVID-19SeverityEcological studyCOVID-19 (Malaltia) (Catalunya)Àrees temàtiques de la UPC::Matemàtiques i estadística::Anàlisi numèrica::Modelització matemàticaThe transmissibility of omicron using variant screening data from primary care practices (PCP) and hospital admissions. In addition, we used this data from PCP to establish the two periods when delta and omicron were, respectively, dominant (above 95% of cases). After that, we performed a population-based cohort analysis to calculate the rates of hospital and intensive care unit (ICU) admissions for both periods and to estimate reduction in severity. Rate ratios (RR) and 95% confidence intervals (95% CI) were calculated and stratified by age and vaccination status. In a second analysis, the differential substitution model in primary care vs. hospitals allowed us to obtain a population-level average change in severity.We have included 48,874 cases during the delta period and 560,658 during the omicron period. During the delta period, on average, 3.8% of the detected cases required hospitalization for COVID-19. This percentage dropped to 0.9% with omicron [RR of 0.46 (95% CI: 0.43 to 0.49)]. For ICU admissions, it dropped from 0.8 to 0.1% [RR 0.25 (95% CI: 0.21 to 0.28)]. The proportion of cases hospitalized or admitted to ICU was lower in the vaccinated groups, independently of the variant. Omicron was associated with a reduction in risk of admission to hospital and ICU in all age and vaccination status strata. The differential substitution models showed an average RR between 0.19 and 0.50.Both independent methods consistently show an important decrease in severity for omicron relative to delta. The systematic reduction happens regardless of age. The severity is also reduced for non-vaccinated and vaccinated groups, but it remains always higher in the non-vaccinated population. This suggests an overall reduction in severity, which could be intrinsic to the omicron variant. The fact is that the RR in ICU admission is systematically smaller than in hospitalization points in the same direction.MC received funding from la Caixa Foundation ID 100010434, under agreement LCF/PR/GN17/50300003. MC, CP, and SA received funding from Ministerio de Ciencia, Innovación y Universidades and FEDER, with the project PGC2018-095456- B-I00.Objectius de Desenvolupament Sostenible::3 - Salut i BenestarFrontiers Media SA20222022-08-1220222022-09-05journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/372256https://dx.doi.org/10.3389/fpubh.2022.961030reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)InglésengAgencia Estatal de Investigación http://doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PGC2018-095456-B-I00 COMPUTATIONAL MODELLING OF BIOPHYSICAL PROCESSES AT MULTIPLE SCALESopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/3722562026-05-27T15:37:01Z
dc.title.none.fl_str_mv Transmissibility, hospitalization, and intensive care admissions due to omicron compared to delta variants of SARS-CoV-2 in Catalonia: A cohort study and ecological analysis
title Transmissibility, hospitalization, and intensive care admissions due to omicron compared to delta variants of SARS-CoV-2 in Catalonia: A cohort study and ecological analysis
spellingShingle Transmissibility, hospitalization, and intensive care admissions due to omicron compared to delta variants of SARS-CoV-2 in Catalonia: A cohort study and ecological analysis
Català Sabaté, Martí|||0000-0003-3308-9905
COVID-19 (Disease)
COVID-19
Severity
Ecological study
COVID-19 (Malaltia) (Catalunya)
Àrees temàtiques de la UPC::Matemàtiques i estadística::Anàlisi numèrica::Modelització matemàtica
title_short Transmissibility, hospitalization, and intensive care admissions due to omicron compared to delta variants of SARS-CoV-2 in Catalonia: A cohort study and ecological analysis
title_full Transmissibility, hospitalization, and intensive care admissions due to omicron compared to delta variants of SARS-CoV-2 in Catalonia: A cohort study and ecological analysis
title_fullStr Transmissibility, hospitalization, and intensive care admissions due to omicron compared to delta variants of SARS-CoV-2 in Catalonia: A cohort study and ecological analysis
title_full_unstemmed Transmissibility, hospitalization, and intensive care admissions due to omicron compared to delta variants of SARS-CoV-2 in Catalonia: A cohort study and ecological analysis
title_sort Transmissibility, hospitalization, and intensive care admissions due to omicron compared to delta variants of SARS-CoV-2 in Catalonia: A cohort study and ecological analysis
dc.creator.none.fl_str_mv Català Sabaté, Martí|||0000-0003-3308-9905
Coma, Ermengol
Alonso Muñoz, Sergio|||0000-0002-3989-8757
Andres Lacueva, Cristina
Blanco, Ignacio
Antón, Andrés
Escales Bordoy, Antoni
Cardona Iglesias, Pere Joan|||0000-0001-5623-7873
Fina Avilés, Francesc
Martró Català, Elisa
Medina, Manuel
Moras Planes, Núria
Saludes Montoro, Verònica
Prats Soler, Clara|||0000-0002-1398-7559
Prieto Alhambra, Daniel
Álvarez Lacalle, Enrique|||0000-0001-6824-6857
author Català Sabaté, Martí|||0000-0003-3308-9905
author_facet Català Sabaté, Martí|||0000-0003-3308-9905
Coma, Ermengol
Alonso Muñoz, Sergio|||0000-0002-3989-8757
Andres Lacueva, Cristina
Blanco, Ignacio
Antón, Andrés
Escales Bordoy, Antoni
Cardona Iglesias, Pere Joan|||0000-0001-5623-7873
Fina Avilés, Francesc
Martró Català, Elisa
Medina, Manuel
Moras Planes, Núria
Saludes Montoro, Verònica
Prats Soler, Clara|||0000-0002-1398-7559
Prieto Alhambra, Daniel
Álvarez Lacalle, Enrique|||0000-0001-6824-6857
author_role author
author2 Coma, Ermengol
Alonso Muñoz, Sergio|||0000-0002-3989-8757
Andres Lacueva, Cristina
Blanco, Ignacio
Antón, Andrés
Escales Bordoy, Antoni
Cardona Iglesias, Pere Joan|||0000-0001-5623-7873
Fina Avilés, Francesc
Martró Català, Elisa
Medina, Manuel
Moras Planes, Núria
Saludes Montoro, Verònica
Prats Soler, Clara|||0000-0002-1398-7559
Prieto Alhambra, Daniel
Álvarez Lacalle, Enrique|||0000-0001-6824-6857
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv COVID-19 (Disease)
COVID-19
Severity
Ecological study
COVID-19 (Malaltia) (Catalunya)
Àrees temàtiques de la UPC::Matemàtiques i estadística::Anàlisi numèrica::Modelització matemàtica
topic COVID-19 (Disease)
COVID-19
Severity
Ecological study
COVID-19 (Malaltia) (Catalunya)
Àrees temàtiques de la UPC::Matemàtiques i estadística::Anàlisi numèrica::Modelització matemàtica
description The transmissibility of omicron using variant screening data from primary care practices (PCP) and hospital admissions. In addition, we used this data from PCP to establish the two periods when delta and omicron were, respectively, dominant (above 95% of cases). After that, we performed a population-based cohort analysis to calculate the rates of hospital and intensive care unit (ICU) admissions for both periods and to estimate reduction in severity. Rate ratios (RR) and 95% confidence intervals (95% CI) were calculated and stratified by age and vaccination status. In a second analysis, the differential substitution model in primary care vs. hospitals allowed us to obtain a population-level average change in severity.We have included 48,874 cases during the delta period and 560,658 during the omicron period. During the delta period, on average, 3.8% of the detected cases required hospitalization for COVID-19. This percentage dropped to 0.9% with omicron [RR of 0.46 (95% CI: 0.43 to 0.49)]. For ICU admissions, it dropped from 0.8 to 0.1% [RR 0.25 (95% CI: 0.21 to 0.28)]. The proportion of cases hospitalized or admitted to ICU was lower in the vaccinated groups, independently of the variant. Omicron was associated with a reduction in risk of admission to hospital and ICU in all age and vaccination status strata. The differential substitution models showed an average RR between 0.19 and 0.50.Both independent methods consistently show an important decrease in severity for omicron relative to delta. The systematic reduction happens regardless of age. The severity is also reduced for non-vaccinated and vaccinated groups, but it remains always higher in the non-vaccinated population. This suggests an overall reduction in severity, which could be intrinsic to the omicron variant. The fact is that the RR in ICU admission is systematically smaller than in hospitalization points in the same direction.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-08-12
2022
2022-09-05
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/372256
https://dx.doi.org/10.3389/fpubh.2022.961030
url https://hdl.handle.net/2117/372256
https://dx.doi.org/10.3389/fpubh.2022.961030
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación http://doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PGC2018-095456-B-I00 COMPUTATIONAL MODELLING OF BIOPHYSICAL PROCESSES AT MULTIPLE SCALES
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media SA
publisher.none.fl_str_mv Frontiers Media SA
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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