Decoy-based, targeted inhibition of STAT3: A new step forward for B cell lymphoma immunotherapy

Increasing evidence has linked the aggressiveness of non-Hodgkin’s lymphoma, in particular activated B cell-like type diffuse large B cell lymphomas (ABC-DLBCL), to signaling by toll-like receptor 9 (TLR9)/ MyD88 and STAT3. In this issue of Molecular Therapy, Zhao et al.1 describe a dual function mo...

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Detalles Bibliográficos
Autores: Martínez-Soldevilla, M. (Mario)|||/items/6803c2fb-2204-4c18-b86b-ea7f08a42f99, Pastor-Rodríguez, F. (Fernando)|||/items/b59e53ff-7114-4575-b185-f66ca445890b
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/65526
Acceso en línea:https://hdl.handle.net/10171/65526
Access Level:acceso abierto
Palabra clave:Large B cell lymphomas
Lymphoma
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repository_id_str
spelling Decoy-based, targeted inhibition of STAT3: A new step forward for B cell lymphoma immunotherapyMartínez-Soldevilla, M. (Mario)|||/items/6803c2fb-2204-4c18-b86b-ea7f08a42f99Pastor-Rodríguez, F. (Fernando)|||/items/b59e53ff-7114-4575-b185-f66ca445890bLarge B cell lymphomasLymphomaIncreasing evidence has linked the aggressiveness of non-Hodgkin’s lymphoma, in particular activated B cell-like type diffuse large B cell lymphomas (ABC-DLBCL), to signaling by toll-like receptor 9 (TLR9)/ MyD88 and STAT3. In this issue of Molecular Therapy, Zhao et al.1 describe a dual function molecule comprising a clinically-relevant TLR9 agonist (CpG7909) fused to a STAT3 inhibitor in the form of a high-affinity decoy oligodeoxynucleotide (dODN). CpG-STAT3dODN blocked STAT3 DNA binding and activity, thus reducing expression of downstream target genes, such as MYC and BCL2L1, in human and mouse lymphoma cells. These effects led to the generation of lymphoma cell-specific CD8/ CD4-dependent T cell immunity that could protect mice from tumor rechallenge.Cell PressDadun. Depósito Académico Digital Universidad de Navarra20232023-02-2120182018-01-0120182018-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/65526reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/655262026-06-21T12:47:57Z
dc.title.none.fl_str_mv Decoy-based, targeted inhibition of STAT3: A new step forward for B cell lymphoma immunotherapy
title Decoy-based, targeted inhibition of STAT3: A new step forward for B cell lymphoma immunotherapy
spellingShingle Decoy-based, targeted inhibition of STAT3: A new step forward for B cell lymphoma immunotherapy
Martínez-Soldevilla, M. (Mario)|||/items/6803c2fb-2204-4c18-b86b-ea7f08a42f99
Large B cell lymphomas
Lymphoma
title_short Decoy-based, targeted inhibition of STAT3: A new step forward for B cell lymphoma immunotherapy
title_full Decoy-based, targeted inhibition of STAT3: A new step forward for B cell lymphoma immunotherapy
title_fullStr Decoy-based, targeted inhibition of STAT3: A new step forward for B cell lymphoma immunotherapy
title_full_unstemmed Decoy-based, targeted inhibition of STAT3: A new step forward for B cell lymphoma immunotherapy
title_sort Decoy-based, targeted inhibition of STAT3: A new step forward for B cell lymphoma immunotherapy
dc.creator.none.fl_str_mv Martínez-Soldevilla, M. (Mario)|||/items/6803c2fb-2204-4c18-b86b-ea7f08a42f99
Pastor-Rodríguez, F. (Fernando)|||/items/b59e53ff-7114-4575-b185-f66ca445890b
author Martínez-Soldevilla, M. (Mario)|||/items/6803c2fb-2204-4c18-b86b-ea7f08a42f99
author_facet Martínez-Soldevilla, M. (Mario)|||/items/6803c2fb-2204-4c18-b86b-ea7f08a42f99
Pastor-Rodríguez, F. (Fernando)|||/items/b59e53ff-7114-4575-b185-f66ca445890b
author_role author
author2 Pastor-Rodríguez, F. (Fernando)|||/items/b59e53ff-7114-4575-b185-f66ca445890b
author2_role author
dc.contributor.none.fl_str_mv Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv Large B cell lymphomas
Lymphoma
topic Large B cell lymphomas
Lymphoma
description Increasing evidence has linked the aggressiveness of non-Hodgkin’s lymphoma, in particular activated B cell-like type diffuse large B cell lymphomas (ABC-DLBCL), to signaling by toll-like receptor 9 (TLR9)/ MyD88 and STAT3. In this issue of Molecular Therapy, Zhao et al.1 describe a dual function molecule comprising a clinically-relevant TLR9 agonist (CpG7909) fused to a STAT3 inhibitor in the form of a high-affinity decoy oligodeoxynucleotide (dODN). CpG-STAT3dODN blocked STAT3 DNA binding and activity, thus reducing expression of downstream target genes, such as MYC and BCL2L1, in human and mouse lymphoma cells. These effects led to the generation of lymphoma cell-specific CD8/ CD4-dependent T cell immunity that could protect mice from tumor rechallenge.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01
2018
2018-01-01
2023
2023-02-21
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10171/65526
url https://hdl.handle.net/10171/65526
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra
instname:Universidad de Navarra
instname_str Universidad de Navarra
reponame_str Dadun. Depósito Académico Digital de la Universidad de Navarra
collection Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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