Estrogen Receptor-Alpha (ESR1) Governs the Lower Female Reproductive Tract Vulnerability to Candida albicans

Estradiol-based therapies predispose women to vaginal infections. Moreover, it has long been known that neutrophils are absent from the vaginal lumen during the ovulatory phase (high estradiol). However, the mechanisms that regulate neutrophil influx to the vagina remain unknown. We investigated the...

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Detalles Bibliográficos
Autores: Salinas-Munoz, Laura, Campos-Fernandez, Raul, Mercader, Enrique, Olivera-Valle, Irene, Fernandez-Pacheco, Carlota, Matilla, Lara, Garcia-Bordas, Julio, Brazil, Jennifer C., Parkos, Charles A., Asensio, Fernando, Munoz-Fernandez, Maria A., Hidalgo, Andres, Sanchez-Mateos, Paloma, Samaniego, Rafael, Relloso, Miguel
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/6666
Acceso en línea:http://hdl.handle.net/20.500.12105/6666
Access Level:acceso abierto
Palabra clave:Estradiol
ESR1
Progesterone
Neutrophils
Transepithelial migration
Cervix
NEUTROPHIL-EPITHELIAL INTERACTIONS
TRANSEPITHELIAL MIGRATION
SEX-HORMONES
INTESTINAL EPITHELIUM
CHEMOKINE GRADIENTS
VAGINA
TRANSMIGRATION
IMMUNITY
CELLS
INFILTRATION
Descripción
Sumario:Estradiol-based therapies predispose women to vaginal infections. Moreover, it has long been known that neutrophils are absent from the vaginal lumen during the ovulatory phase (high estradiol). However, the mechanisms that regulate neutrophil influx to the vagina remain unknown. We investigated the neutrophil transepithelial migration (TEM) into the vaginal lumen. We revealed that estradiol reduces the CD44 and CD47 epithelial expression in the vaginal ectocervix and fornix, which retain neutrophils at the apical epithelium through the estradiol receptor-alpha. In contrast, luteal progesterone increases epithelial expression of CD44 and CD47 to promote neutrophil migration into the vaginal lumen and Candida albicans destruction. Distinctive to vaginal mucosa, neutrophil infiltration is contingent to sex hormones to prevent sperm from neutrophil attack; although it may compromise immunity during ovulation. Thus, sex hormones orchestrate tolerance and immunity in the vaginal lumen by regulating neutrophil TEM.

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