Imaging of early inflammation in low-to-moderate carotid stenosis by 18-FDG-PET

It is not clear if 18FDG-PET can be useful for detection of inflammation in low to moderate carotid stenosis. We studied 15 patients scheduled for endarterectomy with contralateral carotids with less than 50% stenosis. 18-FDG-PET was performed prior to CEA and 3 months following surgery. FDG-uptake...

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Detalles Bibliográficos
Autores: Font, M. Angels, Fernández, Alex (Fernández Solanas), Carvajal, Ana, Gámez, Cristina, Badimón, Lina, 1953-, Slevin, Mark, Krupinski, Jerzy
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2009
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/141665
Acceso en línea:https://hdl.handle.net/2445/141665
Access Level:acceso abierto
Palabra clave:Inflamació
Artèries caròtides
Estenosi
Diagnòstic per la imatge
Inflammation
Carotid artery
Stenosis
Diagnostic imaging
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spelling Imaging of early inflammation in low-to-moderate carotid stenosis by 18-FDG-PETFont, M. AngelsFernández, Alex (Fernández Solanas)Carvajal, AnaGámez, CristinaBadimón, Lina, 1953-Slevin, MarkKrupinski, JerzyInflamacióArtèries caròtidesEstenosiDiagnòstic per la imatgeInflammationCarotid arteryStenosisDiagnostic imagingIt is not clear if 18FDG-PET can be useful for detection of inflammation in low to moderate carotid stenosis. We studied 15 patients scheduled for endarterectomy with contralateral carotids with less than 50% stenosis. 18-FDG-PET was performed prior to CEA and 3 months following surgery. FDG-uptake values were calculated based on maximum standardized uptake value (SUV) and corresponding uptake ratios. We confirmed by CD68 macrophage staining that FDG accumulation corresponds to active inflammation (R=0.8 p less than 0.005). We found significant correlation between the FDG-uptake in the carotids scheduled for CEA and contralateral carotids with low to moderate stenosis (R=0.9 p less than 0.001). The FDG uptake ratio in the contralateral arteries remained stable on the follow-up imaging (1.15+/-0.2 vs. 1.14+/-0.1, R=0.7 p=0.006). We did not find correlation between FDG uptake and symptomatic or asymptomatic patients, degree of carotid stenosis and vascular risk factors. This is a prospective, preliminary in vivo study demonstrating that low to moderate carotid atherosclerosis can be detected using 18-FDG-PET imaging and highlights the truly systemic nature of atherosclerosis.Frontiers in Bioscience2009info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/141665Articles publicats en revistes (Ciències Clíniques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.2741/3457Frontiers in Bioscience-Landmark Edition, 2009, vol. 14, p. 3352-3360https://doi.org/10.2741/3457(c) Frontiers in Bioscience, 2009info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1416652026-05-27T06:46:51Z
dc.title.none.fl_str_mv Imaging of early inflammation in low-to-moderate carotid stenosis by 18-FDG-PET
title Imaging of early inflammation in low-to-moderate carotid stenosis by 18-FDG-PET
spellingShingle Imaging of early inflammation in low-to-moderate carotid stenosis by 18-FDG-PET
Font, M. Angels
Inflamació
Artèries caròtides
Estenosi
Diagnòstic per la imatge
Inflammation
Carotid artery
Stenosis
Diagnostic imaging
title_short Imaging of early inflammation in low-to-moderate carotid stenosis by 18-FDG-PET
title_full Imaging of early inflammation in low-to-moderate carotid stenosis by 18-FDG-PET
title_fullStr Imaging of early inflammation in low-to-moderate carotid stenosis by 18-FDG-PET
title_full_unstemmed Imaging of early inflammation in low-to-moderate carotid stenosis by 18-FDG-PET
title_sort Imaging of early inflammation in low-to-moderate carotid stenosis by 18-FDG-PET
dc.creator.none.fl_str_mv Font, M. Angels
Fernández, Alex (Fernández Solanas)
Carvajal, Ana
Gámez, Cristina
Badimón, Lina, 1953-
Slevin, Mark
Krupinski, Jerzy
author Font, M. Angels
author_facet Font, M. Angels
Fernández, Alex (Fernández Solanas)
Carvajal, Ana
Gámez, Cristina
Badimón, Lina, 1953-
Slevin, Mark
Krupinski, Jerzy
author_role author
author2 Fernández, Alex (Fernández Solanas)
Carvajal, Ana
Gámez, Cristina
Badimón, Lina, 1953-
Slevin, Mark
Krupinski, Jerzy
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Inflamació
Artèries caròtides
Estenosi
Diagnòstic per la imatge
Inflammation
Carotid artery
Stenosis
Diagnostic imaging
topic Inflamació
Artèries caròtides
Estenosi
Diagnòstic per la imatge
Inflammation
Carotid artery
Stenosis
Diagnostic imaging
description It is not clear if 18FDG-PET can be useful for detection of inflammation in low to moderate carotid stenosis. We studied 15 patients scheduled for endarterectomy with contralateral carotids with less than 50% stenosis. 18-FDG-PET was performed prior to CEA and 3 months following surgery. FDG-uptake values were calculated based on maximum standardized uptake value (SUV) and corresponding uptake ratios. We confirmed by CD68 macrophage staining that FDG accumulation corresponds to active inflammation (R=0.8 p less than 0.005). We found significant correlation between the FDG-uptake in the carotids scheduled for CEA and contralateral carotids with low to moderate stenosis (R=0.9 p less than 0.001). The FDG uptake ratio in the contralateral arteries remained stable on the follow-up imaging (1.15+/-0.2 vs. 1.14+/-0.1, R=0.7 p=0.006). We did not find correlation between FDG uptake and symptomatic or asymptomatic patients, degree of carotid stenosis and vascular risk factors. This is a prospective, preliminary in vivo study demonstrating that low to moderate carotid atherosclerosis can be detected using 18-FDG-PET imaging and highlights the truly systemic nature of atherosclerosis.
publishDate 2009
dc.date.none.fl_str_mv 2009
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/141665
url https://hdl.handle.net/2445/141665
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.2741/3457
Frontiers in Bioscience-Landmark Edition, 2009, vol. 14, p. 3352-3360
https://doi.org/10.2741/3457
dc.rights.none.fl_str_mv (c) Frontiers in Bioscience, 2009
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Frontiers in Bioscience, 2009
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers in Bioscience
publisher.none.fl_str_mv Frontiers in Bioscience
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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