Evaluation of trained immunity as a potential strategy for a universal Streptococcus suis vaccine using immunogenic proteins in a murine model

Universal vaccine against Streptococcus suis (S. suis) remains a challenge due to the high number of serotypes/strains, the absence of cross-protection among them and the existence of different immune escape strategies. In this study, the immunomodulatory potential of live and inactivated porcine de...

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Detalles Bibliográficos
Autores: Sánchez-Morales, Lidia, Zamora, Leydis, Pérez-Sancho, Marta, García-Seco, Teresa, Moreno, Inmaculada, Pérez-Domingo, Andrea, Díaz-Frutos, Marta, Ciordia, Sergio, Buendía, Aránzazu, de Los Ángeles Risalde, María, Domínguez, Mercedes, Domínguez, Lucas
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2026
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/422812
Acceso en línea:http://hdl.handle.net/10261/422812
https://api.elsevier.com/content/abstract/scopus_id/105029011361
Access Level:acceso abierto
Palabra clave:S. suis
BCG
DpB
IFN-γ
Trained immunity
Descripción
Sumario:Universal vaccine against Streptococcus suis (S. suis) remains a challenge due to the high number of serotypes/strains, the absence of cross-protection among them and the existence of different immune escape strategies. In this study, the immunomodulatory potential of live and inactivated porcine derived Bacillus Calmette-Guérin (dpB) in combination with specific immunogenic proteins S. suis is evaluated in murine model.

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