Oral antibiotic prophylaxis lowers surgical site infection in elective colorectal surgery: results of a pragmatic cohort study in Catalonia

Background: The role of oral antibiotic prophylaxis (OAP) and mechanical bowel preparation (MBP) in the prevention of surgical site infection (SSI) after colorectal surgery is still controversial. The aim of this study was to analyze the effect of a bundle including both measures in a National Infec...

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Autores: Badia, Josep M., Flores-Yelamos, Miriam, Vázquez, Ana, Arroyo García, Nares, Puig Asensio, Mireia, Parés, David, Pera Román, Miguel, López-Contreras, Joaquín, Limón, Enrique, Pujol Rojo, Miquel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/182438
Acceso en línea:https://hdl.handle.net/2445/182438
Access Level:acceso abierto
Palabra clave:Antibiòtics
Cirurgia colorectal
Infeccions quirúrgiques
Antibiotics
Colorectal surgery
Surgical wound infection
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spelling Oral antibiotic prophylaxis lowers surgical site infection in elective colorectal surgery: results of a pragmatic cohort study in CataloniaBadia, Josep M.Flores-Yelamos, MiriamVázquez, AnaArroyo García, NaresPuig Asensio, MireiaParés, DavidPera Román, MiguelLópez-Contreras, JoaquínLimón, EnriquePujol Rojo, MiquelAntibiòticsCirurgia colorectalInfeccions quirúrgiquesAntibioticsColorectal surgerySurgical wound infectionBackground: The role of oral antibiotic prophylaxis (OAP) and mechanical bowel preparation (MBP) in the prevention of surgical site infection (SSI) after colorectal surgery is still controversial. The aim of this study was to analyze the effect of a bundle including both measures in a National Infection Surveillance Network in Catalonia. Methods: Pragmatic cohort study to assess the effect of OAP and MBP in reducing SSI rate in 65 hospitals, comparing baseline phase (BP: 2007-2015) with implementation phase (IP: 2016-2019). To compare the results, a logistic regression model was established. Results: Out of 34,421 colorectal operations, 5180 had SSIs (15.05%). Overall SSI rate decreased from 18.81% to 11.10% in BP and IP, respectively (OR 0.539, CI95 0.507-0.573, p < 0.0001). Information about bundle implementation was complete in 61.7% of cases. In a univariate analysis, OAP and MBP were independent factors in decreasing overall SSI, with OR 0.555, CI95 0.483-0.638, and OR 0.686, CI95 0.589-0.798, respectively; and similarly, organ/space SSI (O/S-SSI) (OR 0.592, CI95 0.494-0.710, and OR 0.771, CI95 0.630-0.944, respectively). However, only OAP retained its protective effect at both levels at multivariate analyses. Conclusions: oral antibiotic prophylaxis decreased the rates of SSI and O/S-SSI in a large series of elective colorectal surgeryMDPI2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/182438Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/jcm10235636Journal of Clinical Medicine, 2021, vol. 10, num. 23, p. 5636https://doi.org/10.3390/jcm10235636cc-by (c) Badia, Josep M. et al., 2021https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1824382026-05-27T06:46:51Z
dc.title.none.fl_str_mv Oral antibiotic prophylaxis lowers surgical site infection in elective colorectal surgery: results of a pragmatic cohort study in Catalonia
title Oral antibiotic prophylaxis lowers surgical site infection in elective colorectal surgery: results of a pragmatic cohort study in Catalonia
spellingShingle Oral antibiotic prophylaxis lowers surgical site infection in elective colorectal surgery: results of a pragmatic cohort study in Catalonia
Badia, Josep M.
Antibiòtics
Cirurgia colorectal
Infeccions quirúrgiques
Antibiotics
Colorectal surgery
Surgical wound infection
title_short Oral antibiotic prophylaxis lowers surgical site infection in elective colorectal surgery: results of a pragmatic cohort study in Catalonia
title_full Oral antibiotic prophylaxis lowers surgical site infection in elective colorectal surgery: results of a pragmatic cohort study in Catalonia
title_fullStr Oral antibiotic prophylaxis lowers surgical site infection in elective colorectal surgery: results of a pragmatic cohort study in Catalonia
title_full_unstemmed Oral antibiotic prophylaxis lowers surgical site infection in elective colorectal surgery: results of a pragmatic cohort study in Catalonia
title_sort Oral antibiotic prophylaxis lowers surgical site infection in elective colorectal surgery: results of a pragmatic cohort study in Catalonia
dc.creator.none.fl_str_mv Badia, Josep M.
Flores-Yelamos, Miriam
Vázquez, Ana
Arroyo García, Nares
Puig Asensio, Mireia
Parés, David
Pera Román, Miguel
López-Contreras, Joaquín
Limón, Enrique
Pujol Rojo, Miquel
author Badia, Josep M.
author_facet Badia, Josep M.
Flores-Yelamos, Miriam
Vázquez, Ana
Arroyo García, Nares
Puig Asensio, Mireia
Parés, David
Pera Román, Miguel
López-Contreras, Joaquín
Limón, Enrique
Pujol Rojo, Miquel
author_role author
author2 Flores-Yelamos, Miriam
Vázquez, Ana
Arroyo García, Nares
Puig Asensio, Mireia
Parés, David
Pera Román, Miguel
López-Contreras, Joaquín
Limón, Enrique
Pujol Rojo, Miquel
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Antibiòtics
Cirurgia colorectal
Infeccions quirúrgiques
Antibiotics
Colorectal surgery
Surgical wound infection
topic Antibiòtics
Cirurgia colorectal
Infeccions quirúrgiques
Antibiotics
Colorectal surgery
Surgical wound infection
description Background: The role of oral antibiotic prophylaxis (OAP) and mechanical bowel preparation (MBP) in the prevention of surgical site infection (SSI) after colorectal surgery is still controversial. The aim of this study was to analyze the effect of a bundle including both measures in a National Infection Surveillance Network in Catalonia. Methods: Pragmatic cohort study to assess the effect of OAP and MBP in reducing SSI rate in 65 hospitals, comparing baseline phase (BP: 2007-2015) with implementation phase (IP: 2016-2019). To compare the results, a logistic regression model was established. Results: Out of 34,421 colorectal operations, 5180 had SSIs (15.05%). Overall SSI rate decreased from 18.81% to 11.10% in BP and IP, respectively (OR 0.539, CI95 0.507-0.573, p < 0.0001). Information about bundle implementation was complete in 61.7% of cases. In a univariate analysis, OAP and MBP were independent factors in decreasing overall SSI, with OR 0.555, CI95 0.483-0.638, and OR 0.686, CI95 0.589-0.798, respectively; and similarly, organ/space SSI (O/S-SSI) (OR 0.592, CI95 0.494-0.710, and OR 0.771, CI95 0.630-0.944, respectively). However, only OAP retained its protective effect at both levels at multivariate analyses. Conclusions: oral antibiotic prophylaxis decreased the rates of SSI and O/S-SSI in a large series of elective colorectal surgery
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/182438
url https://hdl.handle.net/2445/182438
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/jcm10235636
Journal of Clinical Medicine, 2021, vol. 10, num. 23, p. 5636
https://doi.org/10.3390/jcm10235636
dc.rights.none.fl_str_mv cc-by (c) Badia, Josep M. et al., 2021
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Badia, Josep M. et al., 2021
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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