The association between age and telomere length is age-dependent: Evidence for a threshold model of telomere length maintenance

Telomere length and dynamics are commonly used biomarkers of somatic state, yet the role of telomeres underlying the aging process is still debated. Indeed, to date, empirical evidence for an association between age and telomere length is mixed. Here, we test if the age-dependency of the association...

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Authors: Romero-Haro, Ana A., Mulder, Ellis, Haussmann, Mark F., Tschirren, Barbara
Format: article
Status:Published version
Publication Date:2024
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/360387
Online Access:http://hdl.handle.net/10261/360387
Access Level:Open access
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spelling The association between age and telomere length is age-dependent: Evidence for a threshold model of telomere length maintenanceRomero-Haro, Ana A.Mulder, EllisHaussmann, Mark F.Tschirren, BarbaraTelomere length and dynamics are commonly used biomarkers of somatic state, yet the role of telomeres underlying the aging process is still debated. Indeed, to date, empirical evidence for an association between age and telomere length is mixed. Here, we test if the age-dependency of the association between age and telomere length can provide a potential explanation for the reported inconsistencies across studies. To this end, we quantified telomere length by telomere restriction fragment analysis in two groups of Japanese quail (Coturnix japonica) that differed in their age distribution. One group consisted of young adults only, whereas the second group consisted of adults across a wide range of ages. In the young adults group, there was a highly significant negative association between telomere length and age, whereas no association between age and telomere length was found in the all-ages adults group. This difference between groups was not due to telomere length-dependent selective disappearance. Our results shows that the association between telomere length and age is age-dependent and suggest that the costs and benefits associated with telomere maintenance are dynamic across an individual's life course.The study was financially supported by the Swiss National Science Foundation (PP00P3_128386 and PP00P3_157455 to Barbara Tschirren). Ana Á. Romero-Haro was supported by the European Union's Horizon 2020 research and innovation program under the Marie Skłodowska-Curie Grant Agreement 842085 and by a postdoctoral contract María Zambrano (University of Castilla-La Mancha) from the Program of Requalification of the Spanish University System (Spanish Ministry of Universities), financed by the European Union—NextGenerationEU (grant agreement MZ2021: 2022-POST-21023). Ana Á. Romero-Haro received additional support for laboratory analyses from a traveling fellowship of The Company of Biologists Limited (charity no. 277992), sponsored by the Journal of Experimental Biology (www.biologists.com/travelling-fellowships).Peer reviewedWiley-VCHSwiss National Science FoundationEuropean CommissionMinisterio de Universidades (España)Universidad de Castilla La ManchaCompany of BiologistsConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/360387reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/H2020/842085The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.1002/jez.2785Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3603872026-05-22T06:33:51Z
dc.title.none.fl_str_mv The association between age and telomere length is age-dependent: Evidence for a threshold model of telomere length maintenance
title The association between age and telomere length is age-dependent: Evidence for a threshold model of telomere length maintenance
spellingShingle The association between age and telomere length is age-dependent: Evidence for a threshold model of telomere length maintenance
Romero-Haro, Ana A.
title_short The association between age and telomere length is age-dependent: Evidence for a threshold model of telomere length maintenance
title_full The association between age and telomere length is age-dependent: Evidence for a threshold model of telomere length maintenance
title_fullStr The association between age and telomere length is age-dependent: Evidence for a threshold model of telomere length maintenance
title_full_unstemmed The association between age and telomere length is age-dependent: Evidence for a threshold model of telomere length maintenance
title_sort The association between age and telomere length is age-dependent: Evidence for a threshold model of telomere length maintenance
dc.creator.none.fl_str_mv Romero-Haro, Ana A.
Mulder, Ellis
Haussmann, Mark F.
Tschirren, Barbara
author Romero-Haro, Ana A.
author_facet Romero-Haro, Ana A.
Mulder, Ellis
Haussmann, Mark F.
Tschirren, Barbara
author_role author
author2 Mulder, Ellis
Haussmann, Mark F.
Tschirren, Barbara
author2_role author
author
author
dc.contributor.none.fl_str_mv Swiss National Science Foundation
European Commission
Ministerio de Universidades (España)
Universidad de Castilla La Mancha
Company of Biologists
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
description Telomere length and dynamics are commonly used biomarkers of somatic state, yet the role of telomeres underlying the aging process is still debated. Indeed, to date, empirical evidence for an association between age and telomere length is mixed. Here, we test if the age-dependency of the association between age and telomere length can provide a potential explanation for the reported inconsistencies across studies. To this end, we quantified telomere length by telomere restriction fragment analysis in two groups of Japanese quail (Coturnix japonica) that differed in their age distribution. One group consisted of young adults only, whereas the second group consisted of adults across a wide range of ages. In the young adults group, there was a highly significant negative association between telomere length and age, whereas no association between age and telomere length was found in the all-ages adults group. This difference between groups was not due to telomere length-dependent selective disappearance. Our results shows that the association between telomere length and age is age-dependent and suggest that the costs and benefits associated with telomere maintenance are dynamic across an individual's life course.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/360387
url http://hdl.handle.net/10261/360387
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/EC/H2020/842085
The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI 10.1002/jez.2785
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley-VCH
publisher.none.fl_str_mv Wiley-VCH
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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