Tumorigenesis and cell competition in Drosophila in the absence of polyhomeotic function

Cell competition is a homeostatic process that eliminates by apoptosis unfit or undesirable cells from animal tissues, including tumor cells that appear during the life of the organism. In Drosophila there is evidence that many types of oncogenic cells are eliminated by cell competition. One excepti...

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Detalles Bibliográficos
Autores: Medina, Izame, Calleja, Manuel, Morata, Ginés
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/270956
Acceso en línea:http://hdl.handle.net/10261/270956
Access Level:acceso abierto
Palabra clave:Cell competition
Polyhomeotic
JNK
Tumors
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spelling Tumorigenesis and cell competition in Drosophila in the absence of polyhomeotic functionMedina, IzameCalleja, ManuelMorata, GinésCell competitionPolyhomeoticJNKTumorsCell competition is a homeostatic process that eliminates by apoptosis unfit or undesirable cells from animal tissues, including tumor cells that appear during the life of the organism. In Drosophila there is evidence that many types of oncogenic cells are eliminated by cell competition. One exception is cells mutant for polyhomeotic (ph), a member of the Polycomb family of genes; most of the isolated mutant ph clones survive and develop tumorous overgrowths in imaginal discs. To characterize the tumorigenic effect of the lack of ph, we first studied the growth of different regions of the wing disc deficient in ph activity and found that the effect is restricted to the proximal appendage. Moreover, we found that ph-deficient tissue is partially refractory to apoptosis. Second, we analyzed the behavior of clones lacking ph function and found that many suffer cell competition but are not completely eliminated. Unexpectedly, we found that nonmutant cells also undergo cell competition when surrounded by ph-deficient cells, indicating that within the same tissue cell competition may operate in opposite directions. We suggest two reasons for the incompleteness of cell competition in ph mutant cells: 1) These cells are partially refractory to apoptosis, and 2) the loss of ph function alters the identity of imaginal cells and subsequently their cell affinities. It compromises the winner/loser interaction, a prerequisite for cell competitionGC 2018-095151-B-100 from the Spanish Ministerio de Ciencia e Innovación, and Grant PIE 202020E255 from the Consejo Superior de Investigaciones CientıficasMinisterio de Ciencia e Innovación (España)Consejo Superior de Investigaciones Científicas (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2022202220212022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/270956reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1073/pnas.2110062118Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2709562026-05-22T06:33:51Z
dc.title.none.fl_str_mv Tumorigenesis and cell competition in Drosophila in the absence of polyhomeotic function
title Tumorigenesis and cell competition in Drosophila in the absence of polyhomeotic function
spellingShingle Tumorigenesis and cell competition in Drosophila in the absence of polyhomeotic function
Medina, Izame
Cell competition
Polyhomeotic
JNK
Tumors
title_short Tumorigenesis and cell competition in Drosophila in the absence of polyhomeotic function
title_full Tumorigenesis and cell competition in Drosophila in the absence of polyhomeotic function
title_fullStr Tumorigenesis and cell competition in Drosophila in the absence of polyhomeotic function
title_full_unstemmed Tumorigenesis and cell competition in Drosophila in the absence of polyhomeotic function
title_sort Tumorigenesis and cell competition in Drosophila in the absence of polyhomeotic function
dc.creator.none.fl_str_mv Medina, Izame
Calleja, Manuel
Morata, Ginés
author Medina, Izame
author_facet Medina, Izame
Calleja, Manuel
Morata, Ginés
author_role author
author2 Calleja, Manuel
Morata, Ginés
author2_role author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (España)
Consejo Superior de Investigaciones Científicas (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Cell competition
Polyhomeotic
JNK
Tumors
topic Cell competition
Polyhomeotic
JNK
Tumors
description Cell competition is a homeostatic process that eliminates by apoptosis unfit or undesirable cells from animal tissues, including tumor cells that appear during the life of the organism. In Drosophila there is evidence that many types of oncogenic cells are eliminated by cell competition. One exception is cells mutant for polyhomeotic (ph), a member of the Polycomb family of genes; most of the isolated mutant ph clones survive and develop tumorous overgrowths in imaginal discs. To characterize the tumorigenic effect of the lack of ph, we first studied the growth of different regions of the wing disc deficient in ph activity and found that the effect is restricted to the proximal appendage. Moreover, we found that ph-deficient tissue is partially refractory to apoptosis. Second, we analyzed the behavior of clones lacking ph function and found that many suffer cell competition but are not completely eliminated. Unexpectedly, we found that nonmutant cells also undergo cell competition when surrounded by ph-deficient cells, indicating that within the same tissue cell competition may operate in opposite directions. We suggest two reasons for the incompleteness of cell competition in ph mutant cells: 1) These cells are partially refractory to apoptosis, and 2) the loss of ph function alters the identity of imaginal cells and subsequently their cell affinities. It compromises the winner/loser interaction, a prerequisite for cell competition
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/270956
url http://hdl.handle.net/10261/270956
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1073/pnas.2110062118
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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