Variable interplay of UV-induced DNA damage and repair at transcription factor binding sites

Llocs d’unió; Dany en l'ADN; Factor de transcripció

Detalhes bibliográficos
Autores: Sabarinathan, Radhakrishnan, Lopez-Bigas, Nuria, Frigola Rissech, Joan, Gonzalez-Perez, Abel
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Recursos:Departament de Salut de la Generalitat de Catalunya (DS)
Repositorio:Scientia. Dipòsit d'Informació Digital del Departament de Salut
OAI Identifier:oai:scientiasalut.gencat.cat:11351/6102
Acesso em linha:https://hdl.handle.net/11351/6102
Access Level:acceso abierto
Palavra-chave:ADN - Dany
Radiació - Efectes fisiològics
Melanoma
PHENOMENA AND PROCESSES::Genetic Phenomena::DNA Damage
Other subheadings::Other subheadings::/radiation effects
DISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms::Neoplasms by Histologic Type::Neoplasms::Neoplasms by Histologic Type::Nevi and Melanomas::Melanoma
FENÓMENOS Y PROCESOS::fenómenos genéticos::daño del ADN
Otros calificadores::Otros calificadores::/efectos de la radiación
ENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias::neoplasias por tipo histológico::neoplasias::neoplasias por tipo histológico::nevos y melanomas::melanoma
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oai_identifier_str oai:scientiasalut.gencat.cat:11351/6102
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Variable interplay of UV-induced DNA damage and repair at transcription factor binding sites
title Variable interplay of UV-induced DNA damage and repair at transcription factor binding sites
spellingShingle Variable interplay of UV-induced DNA damage and repair at transcription factor binding sites
Sabarinathan, Radhakrishnan
ADN - Dany
Radiació - Efectes fisiològics
Melanoma
PHENOMENA AND PROCESSES::Genetic Phenomena::DNA Damage
Other subheadings::Other subheadings::/radiation effects
DISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms::Neoplasms by Histologic Type::Neoplasms::Neoplasms by Histologic Type::Nevi and Melanomas::Melanoma
FENÓMENOS Y PROCESOS::fenómenos genéticos::daño del ADN
Otros calificadores::Otros calificadores::/efectos de la radiación
ENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias::neoplasias por tipo histológico::neoplasias::neoplasias por tipo histológico::nevos y melanomas::melanoma
title_short Variable interplay of UV-induced DNA damage and repair at transcription factor binding sites
title_full Variable interplay of UV-induced DNA damage and repair at transcription factor binding sites
title_fullStr Variable interplay of UV-induced DNA damage and repair at transcription factor binding sites
title_full_unstemmed Variable interplay of UV-induced DNA damage and repair at transcription factor binding sites
title_sort Variable interplay of UV-induced DNA damage and repair at transcription factor binding sites
dc.creator.none.fl_str_mv Sabarinathan, Radhakrishnan
Lopez-Bigas, Nuria
Frigola Rissech, Joan
Gonzalez-Perez, Abel
author Sabarinathan, Radhakrishnan
author_facet Sabarinathan, Radhakrishnan
Lopez-Bigas, Nuria
Frigola Rissech, Joan
Gonzalez-Perez, Abel
author_role author
author2 Lopez-Bigas, Nuria
Frigola Rissech, Joan
Gonzalez-Perez, Abel
author2_role author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Frigola J] Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain. Thoracic Tumors & Head and Neck Cancer Group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Sabarinathan R] National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore, India. [Gonzalez-Perez A] Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain. Research Program on Biomedical Informatics, Universitat Pompeu Fabra,Barcelona, Catalonia, Spain. [Lopez-Bigas N] Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain. Research Program on Biomedical Informatics, Universitat Pompeu Fabra, Barcelona, Catalonia, Spain. Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv ADN - Dany
Radiació - Efectes fisiològics
Melanoma
PHENOMENA AND PROCESSES::Genetic Phenomena::DNA Damage
Other subheadings::Other subheadings::/radiation effects
DISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms::Neoplasms by Histologic Type::Neoplasms::Neoplasms by Histologic Type::Nevi and Melanomas::Melanoma
FENÓMENOS Y PROCESOS::fenómenos genéticos::daño del ADN
Otros calificadores::Otros calificadores::/efectos de la radiación
ENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias::neoplasias por tipo histológico::neoplasias::neoplasias por tipo histológico::nevos y melanomas::melanoma
topic ADN - Dany
Radiació - Efectes fisiològics
Melanoma
PHENOMENA AND PROCESSES::Genetic Phenomena::DNA Damage
Other subheadings::Other subheadings::/radiation effects
DISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms::Neoplasms by Histologic Type::Neoplasms::Neoplasms by Histologic Type::Nevi and Melanomas::Melanoma
FENÓMENOS Y PROCESOS::fenómenos genéticos::daño del ADN
Otros calificadores::Otros calificadores::/efectos de la radiación
ENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias::neoplasias por tipo histológico::neoplasias::neoplasias por tipo histológico::nevos y melanomas::melanoma
description Llocs d’unió; Dany en l'ADN; Factor de transcripció
publishDate 2020
dc.date.none.fl_str_mv 2020
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/6102
url https://hdl.handle.net/11351/6102
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Nucleic Acids Research;49(2)
https://academic.oup.com/nar/article/49/2/891/6042961
info:eu-repo/grantAgreement/EC/H2020/682398
info:eu-repo/grantAgreement/ES/PE2013-2016/SAF2015-66084-R
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv Scientia
reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname:Departament de Salut de la Generalitat de Catalunya (DS)
instname_str Departament de Salut de la Generalitat de Catalunya (DS)
reponame_str Scientia. Dipòsit d'Informació Digital del Departament de Salut
collection Scientia. Dipòsit d'Informació Digital del Departament de Salut
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869424042706993152
spelling Variable interplay of UV-induced DNA damage and repair at transcription factor binding sitesSabarinathan, RadhakrishnanLopez-Bigas, NuriaFrigola Rissech, JoanGonzalez-Perez, AbelADN - DanyRadiació - Efectes fisiològicsMelanomaPHENOMENA AND PROCESSES::Genetic Phenomena::DNA DamageOther subheadings::Other subheadings::/radiation effectsDISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms::Neoplasms by Histologic Type::Neoplasms::Neoplasms by Histologic Type::Nevi and Melanomas::MelanomaFENÓMENOS Y PROCESOS::fenómenos genéticos::daño del ADNOtros calificadores::Otros calificadores::/efectos de la radiaciónENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias::neoplasias por tipo histológico::neoplasias::neoplasias por tipo histológico::nevos y melanomas::melanomaLlocs d’unió; Dany en l'ADN; Factor de transcripcióSitios de unión; Daño en el ADN; Factor de transcripcionBinding sites; Dna damage; Transcription factorAn abnormally high rate of UV-light related mutations appears at transcription factor binding sites (TFBS) across melanomas. The binding of transcription factors (TFs) to the DNA impairs the repair of UV-induced lesions and certain TFs have been shown to increase the rate of generation of these lesions at their binding sites. However, the precise contribution of these two elements to the increase in mutation rate at TFBS in these malignant cells is not understood. Here, exploiting nucleotide-resolution data, we computed the rate of formation and repair of UV-lesions within the binding sites of TFs of different families. We observed, at certain dipyrimidine positions within the binding site of TFs in the Tryptophan Cluster family, an increased rate of formation of UV-induced lesions, corroborating previous studies. Nevertheless, across most families of TFs, the observed increased mutation rate within the entire DNA region covered by the protein results from the decreased repair efficiency. While the rate of mutations across all TFBS does not agree with the amount of UV-induced lesions observed immediately after UV exposure, it strongly agrees with that observed after 48 h. This corroborates the determinant role of the impaired repair in the observed increase of mutation rate.N.L.-B. acknowledges funding from the European Research Council [consolidator grant 682398]; Spanish Ministry of Economy and Competitiveness [SAF2015-66084-R, MINECO/FEDER to U.E.]; IRB Barcelona is a recipient of a Severo Ochoa Centre of Excellence Award from the Spanish Ministry of Economy and Competitiveness (MINECO; Government of Spain) and is supported by CERCA (Generalitat de Catalunya); R.S. acknowledges funding support from the National Centre for Biological Sciences (NCBS-TIFR), Bangalore, India. Funding for open access charge: Spanish Ministry of Economy and Competitiveness.Oxford University PressInstitut Català de la Salut[Frigola J] Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain. Thoracic Tumors & Head and Neck Cancer Group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Sabarinathan R] National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore, India. [Gonzalez-Perez A] Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain. Research Program on Biomedical Informatics, Universitat Pompeu Fabra,Barcelona, Catalonia, Spain. [Lopez-Bigas N] Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain. Research Program on Biomedical Informatics, Universitat Pompeu Fabra, Barcelona, Catalonia, Spain. Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, SpainVall d'Hebron Barcelona Hospital Campus2021202120202021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/6102Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésNucleic Acids Research;49(2)https://academic.oup.com/nar/article/49/2/891/6042961info:eu-repo/grantAgreement/EC/H2020/682398info:eu-repo/grantAgreement/ES/PE2013-2016/SAF2015-66084-RAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/61022026-06-12T09:38:37Z
score 15,811543

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