Circadian Patterns of Patients with Type 2 Diabetes and Obstructive Sleep Apnea

Índex d’apnea-hipopnea; Circadià; Hemoglobina glicada

Detalhes bibliográficos
Autores: Cambras, Trinitat, Romero Santo-Tomas, Odile, Díez-Noguera, Antoni, Sampol Rubio, Gabriel, Lecube, Albert
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Recursos:Departament de Salut de la Generalitat de Catalunya (DS)
Repositorio:Scientia. Dipòsit d'Informació Digital del Departament de Salut
OAI Identifier:oai:scientiasalut.gencat.cat:11351/5963
Acesso em linha:https://hdl.handle.net/11351/5963
Access Level:acceso abierto
Palavra-chave:Ritmes circadiaris
Diabetis no-insulinodependent
Apnea
PHENOMENA AND PROCESSES::Physiological Phenomena::Chronobiology Phenomena::Periodicity::Circadian Rhythm
DISEASES::Endocrine System Diseases::Diabetes Mellitus::Diabetes Mellitus, Type 2
DISEASES::Respiratory Tract Diseases::Respiration Disorders::Apnea::Sleep Apnea Syndromes::Sleep Apnea, Obstructive
FENÓMENOS Y PROCESOS::fenómenos fisiológicos::fenómenos cronobiológicos::periodicidad::ritmo circadiano
ENFERMEDADES::enfermedades del sistema endocrino::diabetes mellitus::diabetes mellitus tipo II
ENFERMEDADES::enfermedades respiratorias::trastornos respiratorios::apnea::síndromes de apnea del sueño::apnea obstructiva del sueño
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dc.title.none.fl_str_mv Circadian Patterns of Patients with Type 2 Diabetes and Obstructive Sleep Apnea
title Circadian Patterns of Patients with Type 2 Diabetes and Obstructive Sleep Apnea
spellingShingle Circadian Patterns of Patients with Type 2 Diabetes and Obstructive Sleep Apnea
Cambras, Trinitat
Ritmes circadiaris
Diabetis no-insulinodependent
Apnea
PHENOMENA AND PROCESSES::Physiological Phenomena::Chronobiology Phenomena::Periodicity::Circadian Rhythm
DISEASES::Endocrine System Diseases::Diabetes Mellitus::Diabetes Mellitus, Type 2
DISEASES::Respiratory Tract Diseases::Respiration Disorders::Apnea::Sleep Apnea Syndromes::Sleep Apnea, Obstructive
FENÓMENOS Y PROCESOS::fenómenos fisiológicos::fenómenos cronobiológicos::periodicidad::ritmo circadiano
ENFERMEDADES::enfermedades del sistema endocrino::diabetes mellitus::diabetes mellitus tipo II
ENFERMEDADES::enfermedades respiratorias::trastornos respiratorios::apnea::síndromes de apnea del sueño::apnea obstructiva del sueño
title_short Circadian Patterns of Patients with Type 2 Diabetes and Obstructive Sleep Apnea
title_full Circadian Patterns of Patients with Type 2 Diabetes and Obstructive Sleep Apnea
title_fullStr Circadian Patterns of Patients with Type 2 Diabetes and Obstructive Sleep Apnea
title_full_unstemmed Circadian Patterns of Patients with Type 2 Diabetes and Obstructive Sleep Apnea
title_sort Circadian Patterns of Patients with Type 2 Diabetes and Obstructive Sleep Apnea
dc.creator.none.fl_str_mv Cambras, Trinitat
Romero Santo-Tomas, Odile
Díez-Noguera, Antoni
Sampol Rubio, Gabriel
Lecube, Albert
author Cambras, Trinitat
author_facet Cambras, Trinitat
Romero Santo-Tomas, Odile
Díez-Noguera, Antoni
Sampol Rubio, Gabriel
Lecube, Albert
author_role author
author2 Romero Santo-Tomas, Odile
Díez-Noguera, Antoni
Sampol Rubio, Gabriel
Lecube, Albert
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Cambras T, Díez-Noguera A] Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Sciences, Universitat de Barcelonan, 08028 Barcelona, Spain. [Romero O, Sampol G] Unitat del Son, Servei de Neurofisiologia Clínica i Servei de Pneumologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain. [Lecube A] Department of Endocrinology and Nutrition, University Hospital Arnau de Vilanova, 25198 Lleida, Spain. Obesity, Diabetes and Metabolism Research Group (ODIM), Biomedical Research Institute of Lleida, (IRBLleida), Universitat de Lleida, 25198 Lleida, Spain. CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Ritmes circadiaris
Diabetis no-insulinodependent
Apnea
PHENOMENA AND PROCESSES::Physiological Phenomena::Chronobiology Phenomena::Periodicity::Circadian Rhythm
DISEASES::Endocrine System Diseases::Diabetes Mellitus::Diabetes Mellitus, Type 2
DISEASES::Respiratory Tract Diseases::Respiration Disorders::Apnea::Sleep Apnea Syndromes::Sleep Apnea, Obstructive
FENÓMENOS Y PROCESOS::fenómenos fisiológicos::fenómenos cronobiológicos::periodicidad::ritmo circadiano
ENFERMEDADES::enfermedades del sistema endocrino::diabetes mellitus::diabetes mellitus tipo II
ENFERMEDADES::enfermedades respiratorias::trastornos respiratorios::apnea::síndromes de apnea del sueño::apnea obstructiva del sueño
topic Ritmes circadiaris
Diabetis no-insulinodependent
Apnea
PHENOMENA AND PROCESSES::Physiological Phenomena::Chronobiology Phenomena::Periodicity::Circadian Rhythm
DISEASES::Endocrine System Diseases::Diabetes Mellitus::Diabetes Mellitus, Type 2
DISEASES::Respiratory Tract Diseases::Respiration Disorders::Apnea::Sleep Apnea Syndromes::Sleep Apnea, Obstructive
FENÓMENOS Y PROCESOS::fenómenos fisiológicos::fenómenos cronobiológicos::periodicidad::ritmo circadiano
ENFERMEDADES::enfermedades del sistema endocrino::diabetes mellitus::diabetes mellitus tipo II
ENFERMEDADES::enfermedades respiratorias::trastornos respiratorios::apnea::síndromes de apnea del sueño::apnea obstructiva del sueño
description Índex d’apnea-hipopnea; Circadià; Hemoglobina glicada
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/5963
url https://hdl.handle.net/11351/5963
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Journal of Clinical Medicine;10(2)
https://doi.org/10.3390/jcm10020244
info:eu-repo/grantAgreement/ES/PE2013-2016/PI15%2F00260
info:eu-repo/grantAgreement/ES/1PN/2008-2011
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Scientia
reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname:Departament de Salut de la Generalitat de Catalunya (DS)
instname_str Departament de Salut de la Generalitat de Catalunya (DS)
reponame_str Scientia. Dipòsit d'Informació Digital del Departament de Salut
collection Scientia. Dipòsit d'Informació Digital del Departament de Salut
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869424042056876032
spelling Circadian Patterns of Patients with Type 2 Diabetes and Obstructive Sleep ApneaCambras, TrinitatRomero Santo-Tomas, OdileDíez-Noguera, AntoniSampol Rubio, GabrielLecube, AlbertRitmes circadiarisDiabetis no-insulinodependentApneaPHENOMENA AND PROCESSES::Physiological Phenomena::Chronobiology Phenomena::Periodicity::Circadian RhythmDISEASES::Endocrine System Diseases::Diabetes Mellitus::Diabetes Mellitus, Type 2DISEASES::Respiratory Tract Diseases::Respiration Disorders::Apnea::Sleep Apnea Syndromes::Sleep Apnea, ObstructiveFENÓMENOS Y PROCESOS::fenómenos fisiológicos::fenómenos cronobiológicos::periodicidad::ritmo circadianoENFERMEDADES::enfermedades del sistema endocrino::diabetes mellitus::diabetes mellitus tipo IIENFERMEDADES::enfermedades respiratorias::trastornos respiratorios::apnea::síndromes de apnea del sueño::apnea obstructiva del sueñoÍndex d’apnea-hipopnea; Circadià; Hemoglobina glicadaÍndice de apnea-hipopnea; Circadiano; Hemoglobina glicadaApnea-hypoapnea index; Circadian; Glycated hemoglobinSleep apnea, a condition that modifies sleep and circadian rhythms, is highly prevalent in patients with diabetes. However, it is not known if there is an association between sleep apnea, circadian alterations and glycemic regulation in this type of patient. Here, a polysomnographic study was carried out on 21 women and 25 men (mean age = 64.3 ± 1.46 years) with diagnoses of type 2 diabetes to detect the presence of sleep apnea. Moreover, patients wore an actigraph and a temperature sensor on the wrist for one week, to study the manifestation of the circadian rhythms. The correlations of circadian and polysomnographic variables with the severity of apnea, measured by the apnea-hypopnea index, and with glycemic dysregulation, measured by the percentage of glycated hemoglobin, were analyzed. The mean apnea-hypoapnea index of all the participants was 39.6 ± 4.3. Apnea-hypoapnea index correlated with % N1, negatively with % N3, and also the stability of the active circadian rhythm. However, no significant correlation was found between the apnea-hypopnea index and wrist temperature rhythm and glycated hemoglobin. Glycated hemoglobin levels were negatively associated with the percentage of variance explained by the wrist temperature circadian rhythm (calculated via 24 and 12 h rhythms). This association was independent of body mass index and was strongest in patients with severe apnea. In conclusion, patients with diabetes showed altered circadian rhythms associated with a poor glycemic control and this association could partially be related to the coexistence of sleep apnea.This research was supported by grants from de Instituto de Salud Carlos III ISCIII (Fondo de Investigación Sanitaria PI12/00803 and PI15/00260). European Union (European Regional Development Fund. Fondo Europeo de Desarrollo Regional. FEDER. “Una manera de hacer Europa”). CIBER de Diabetes y Enfermedades Metabólicas Asociadas and CIBER de Enfermedades Respiratorias are initiatives of the Instituto de Salud Carlos III.MDPIInstitut Català de la Salut[Cambras T, Díez-Noguera A] Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Sciences, Universitat de Barcelonan, 08028 Barcelona, Spain. [Romero O, Sampol G] Unitat del Son, Servei de Neurofisiologia Clínica i Servei de Pneumologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain. [Lecube A] Department of Endocrinology and Nutrition, University Hospital Arnau de Vilanova, 25198 Lleida, Spain. Obesity, Diabetes and Metabolism Research Group (ODIM), Biomedical Research Institute of Lleida, (IRBLleida), Universitat de Lleida, 25198 Lleida, Spain. CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), Institute of Health Carlos III (ISCIII), 28029 Madrid, SpainVall d'Hebron Barcelona Hospital Campus202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/5963Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésJournal of Clinical Medicine;10(2)https://doi.org/10.3390/jcm10020244info:eu-repo/grantAgreement/ES/PE2013-2016/PI15%2F00260info:eu-repo/grantAgreement/ES/1PN/2008-2011Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/59632026-06-12T09:38:37Z
score 15,812429

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