Effectiveness of interventions to improve medication adherence in adults with depressive disorders

Non-adherence to medication is a major obstacle in the treatment of depressive disorders. We systematically reviewed the literature to evaluate the effectiveness of interventions aimed at improving adherence to medication among adults with depressive disorders with emphasis on initiation and impleme...

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Autores: González de León, Beatriz, del Pino-Sedeño, Tasmania|||0000-0003-3843-8975, Serrano-Pérez, Pedro|||0000-0001-8652-1170, Rodríguez Álvarez, Cristobalina, Bejarano-Quisoboni, Daniel, Trujillo-Martín, María M.
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:292205
Acceso en línea:https://ddd.uab.cat/record/292205
https://dx.doi.org/urn:doi:10.1186/s12888-022-04120-w
Access Level:acceso abierto
Palabra clave:Major Depressive Disorder
Meta-analysis
Systematic review
Treatment Adherence
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spelling Effectiveness of interventions to improve medication adherence in adults with depressive disordersa meta-analysisGonzález de León, Beatrizdel Pino-Sedeño, Tasmania|||0000-0003-3843-8975Serrano-Pérez, Pedro|||0000-0001-8652-1170Rodríguez Álvarez, CristobalinaBejarano-Quisoboni, DanielTrujillo-Martín, María M.Major Depressive DisorderMeta-analysisSystematic reviewTreatment AdherenceNon-adherence to medication is a major obstacle in the treatment of depressive disorders. We systematically reviewed the literature to evaluate the effectiveness of interventions aimed at improving adherence to medication among adults with depressive disorders with emphasis on initiation and implementation phase. We searched Medline, EMBASE, The Cochrane Central Register of Controlled Trials (CENTRAL), PsycINFO, Social Science Citation Index and Science Citation Index for randomized or non-randomized controlled trials up to January 2022. Risk of bias was assessed using the criteria of the Cochrane Collaboration. Meta-analyses, cumulative and meta-regression analyses for adherence were conducted. Forty-six trials (n = 24,324) were included. Pooled estimate indicates an increase in the probability of adherence to antidepressants at 6 months with the different types of interventions (OR 1.33; 95% CI: 1.09 to 1.62). The improvement in adherence is obtained from 3 months (OR 1.62, 95% CI: 1.25 to 2.10) but it is attenuated at 12 months (OR 1.25, 95% CI: 1.02 to 1.53). Selected articles show methodological differences, mainly the diversity of both the severity of the depressive disorder and intervention procedures. In the samples of these studies, patients with depression and anxiety seem to benefit most from intervention (OR 2.77, 95% CI: 1.74 to 4.42) and collaborative care is the most effective intervention to improve adherence (OR 1.88, 95% CI: 1.40 to 2.54). Our findings indicate that interventions aimed at improving adherence to medication among adults with depressive disorders are effective up to six months. However, the evidence on the effectiveness of long-term adherence is insufficient and supports the need for further research efforts. International Prospective Register for Systematic Reviews (PROSPERO) number: . The online version contains supplementary material available at 10.1186/s12888-022-04120-w.Universitat Autònoma de Barcelona 22022-01-0120222022-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/292205https://dx.doi.org/urn:doi:10.1186/s12888-022-04120-wreponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/00767open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2922052026-06-06T12:50:31Z
dc.title.none.fl_str_mv Effectiveness of interventions to improve medication adherence in adults with depressive disorders
a meta-analysis
title Effectiveness of interventions to improve medication adherence in adults with depressive disorders
spellingShingle Effectiveness of interventions to improve medication adherence in adults with depressive disorders
González de León, Beatriz
Major Depressive Disorder
Meta-analysis
Systematic review
Treatment Adherence
title_short Effectiveness of interventions to improve medication adherence in adults with depressive disorders
title_full Effectiveness of interventions to improve medication adherence in adults with depressive disorders
title_fullStr Effectiveness of interventions to improve medication adherence in adults with depressive disorders
title_full_unstemmed Effectiveness of interventions to improve medication adherence in adults with depressive disorders
title_sort Effectiveness of interventions to improve medication adherence in adults with depressive disorders
dc.creator.none.fl_str_mv González de León, Beatriz
del Pino-Sedeño, Tasmania|||0000-0003-3843-8975
Serrano-Pérez, Pedro|||0000-0001-8652-1170
Rodríguez Álvarez, Cristobalina
Bejarano-Quisoboni, Daniel
Trujillo-Martín, María M.
author González de León, Beatriz
author_facet González de León, Beatriz
del Pino-Sedeño, Tasmania|||0000-0003-3843-8975
Serrano-Pérez, Pedro|||0000-0001-8652-1170
Rodríguez Álvarez, Cristobalina
Bejarano-Quisoboni, Daniel
Trujillo-Martín, María M.
author_role author
author2 del Pino-Sedeño, Tasmania|||0000-0003-3843-8975
Serrano-Pérez, Pedro|||0000-0001-8652-1170
Rodríguez Álvarez, Cristobalina
Bejarano-Quisoboni, Daniel
Trujillo-Martín, María M.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Major Depressive Disorder
Meta-analysis
Systematic review
Treatment Adherence
topic Major Depressive Disorder
Meta-analysis
Systematic review
Treatment Adherence
description Non-adherence to medication is a major obstacle in the treatment of depressive disorders. We systematically reviewed the literature to evaluate the effectiveness of interventions aimed at improving adherence to medication among adults with depressive disorders with emphasis on initiation and implementation phase. We searched Medline, EMBASE, The Cochrane Central Register of Controlled Trials (CENTRAL), PsycINFO, Social Science Citation Index and Science Citation Index for randomized or non-randomized controlled trials up to January 2022. Risk of bias was assessed using the criteria of the Cochrane Collaboration. Meta-analyses, cumulative and meta-regression analyses for adherence were conducted. Forty-six trials (n = 24,324) were included. Pooled estimate indicates an increase in the probability of adherence to antidepressants at 6 months with the different types of interventions (OR 1.33; 95% CI: 1.09 to 1.62). The improvement in adherence is obtained from 3 months (OR 1.62, 95% CI: 1.25 to 2.10) but it is attenuated at 12 months (OR 1.25, 95% CI: 1.02 to 1.53). Selected articles show methodological differences, mainly the diversity of both the severity of the depressive disorder and intervention procedures. In the samples of these studies, patients with depression and anxiety seem to benefit most from intervention (OR 2.77, 95% CI: 1.74 to 4.42) and collaborative care is the most effective intervention to improve adherence (OR 1.88, 95% CI: 1.40 to 2.54). Our findings indicate that interventions aimed at improving adherence to medication among adults with depressive disorders are effective up to six months. However, the evidence on the effectiveness of long-term adherence is insufficient and supports the need for further research efforts. International Prospective Register for Systematic Reviews (PROSPERO) number: . The online version contains supplementary material available at 10.1186/s12888-022-04120-w.
publishDate 2022
dc.date.none.fl_str_mv 2
2022-01-01
2022
2022-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/292205
https://dx.doi.org/urn:doi:10.1186/s12888-022-04120-w
url https://ddd.uab.cat/record/292205
https://dx.doi.org/urn:doi:10.1186/s12888-022-04120-w
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/00767
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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