Single dose of intravenous ferric carboxymaltose infusion versus multiple fractionated doses of intravenous iron sucrose in the treatment of postoperative anaemia in colorectal cancer patients

Patients with colorectal cancer (CRC) often present with associated anaemia which is usually present at the time of diagnosis and is aggravated during the postoperative period due to blood loss during the surgery process. Several guidelines advocate for the treatment of postoperative anaemia in thes...

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Autores: Laso Morales, María Jesús, Vives, Roser|||0000-0002-4369-778X, Vallejo-Tarrat, Andrea, Caló, Novella, Valle-Beltran, Anna, Pontes García, Caridad|||0000-0002-3274-6048
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:226292
Acceso en línea:https://ddd.uab.cat/record/226292
https://dx.doi.org/urn:doi:10.1186/s13063-018-3125-2
Access Level:acceso abierto
Palabra clave:Colorectal cancer
Postoperative anaemia
Intravenous iron
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spelling Single dose of intravenous ferric carboxymaltose infusion versus multiple fractionated doses of intravenous iron sucrose in the treatment of postoperative anaemia in colorectal cancer patientsstudy protocol for a randomised controlled trialLaso Morales, María JesúsVives, Roser|||0000-0002-4369-778XVallejo-Tarrat, AndreaCaló, NovellaValle-Beltran, AnnaPontes García, Caridad|||0000-0002-3274-6048Colorectal cancerPostoperative anaemiaIntravenous ironPatients with colorectal cancer (CRC) often present with associated anaemia which is usually present at the time of diagnosis and is aggravated during the postoperative period due to blood loss during the surgery process. Several guidelines advocate for the treatment of postoperative anaemia in these patients in order to prevent complications and allogeneic blood transfusions. However, there are no publications to shed light on the effectiveness of intravenous iron (IVI) administration after CRC surgery and the optimal dose and regimen. We have started a clinical trial with the objective of comparing the effectiveness of 1000 mg of ferric carboxymaltose with fractionated iron sucrose 200 g/48 h for the treatment of postoperative anaemia, by measuring the change of haemoglobin (Hb) levels from postoperative day (POD) 1 to POD 30. We designed an open label randomised controlled trial to compare two postoperative IVI treatment regimens. Patients agedUniversitat Autònoma de Barcelona 22019-01-0120192019-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/226292https://dx.doi.org/urn:doi:10.1186/s13063-018-3125-2reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2262922026-06-06T12:50:31Z
dc.title.none.fl_str_mv Single dose of intravenous ferric carboxymaltose infusion versus multiple fractionated doses of intravenous iron sucrose in the treatment of postoperative anaemia in colorectal cancer patients
study protocol for a randomised controlled trial
title Single dose of intravenous ferric carboxymaltose infusion versus multiple fractionated doses of intravenous iron sucrose in the treatment of postoperative anaemia in colorectal cancer patients
spellingShingle Single dose of intravenous ferric carboxymaltose infusion versus multiple fractionated doses of intravenous iron sucrose in the treatment of postoperative anaemia in colorectal cancer patients
Laso Morales, María Jesús
Colorectal cancer
Postoperative anaemia
Intravenous iron
title_short Single dose of intravenous ferric carboxymaltose infusion versus multiple fractionated doses of intravenous iron sucrose in the treatment of postoperative anaemia in colorectal cancer patients
title_full Single dose of intravenous ferric carboxymaltose infusion versus multiple fractionated doses of intravenous iron sucrose in the treatment of postoperative anaemia in colorectal cancer patients
title_fullStr Single dose of intravenous ferric carboxymaltose infusion versus multiple fractionated doses of intravenous iron sucrose in the treatment of postoperative anaemia in colorectal cancer patients
title_full_unstemmed Single dose of intravenous ferric carboxymaltose infusion versus multiple fractionated doses of intravenous iron sucrose in the treatment of postoperative anaemia in colorectal cancer patients
title_sort Single dose of intravenous ferric carboxymaltose infusion versus multiple fractionated doses of intravenous iron sucrose in the treatment of postoperative anaemia in colorectal cancer patients
dc.creator.none.fl_str_mv Laso Morales, María Jesús
Vives, Roser|||0000-0002-4369-778X
Vallejo-Tarrat, Andrea
Caló, Novella
Valle-Beltran, Anna
Pontes García, Caridad|||0000-0002-3274-6048
author Laso Morales, María Jesús
author_facet Laso Morales, María Jesús
Vives, Roser|||0000-0002-4369-778X
Vallejo-Tarrat, Andrea
Caló, Novella
Valle-Beltran, Anna
Pontes García, Caridad|||0000-0002-3274-6048
author_role author
author2 Vives, Roser|||0000-0002-4369-778X
Vallejo-Tarrat, Andrea
Caló, Novella
Valle-Beltran, Anna
Pontes García, Caridad|||0000-0002-3274-6048
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Colorectal cancer
Postoperative anaemia
Intravenous iron
topic Colorectal cancer
Postoperative anaemia
Intravenous iron
description Patients with colorectal cancer (CRC) often present with associated anaemia which is usually present at the time of diagnosis and is aggravated during the postoperative period due to blood loss during the surgery process. Several guidelines advocate for the treatment of postoperative anaemia in these patients in order to prevent complications and allogeneic blood transfusions. However, there are no publications to shed light on the effectiveness of intravenous iron (IVI) administration after CRC surgery and the optimal dose and regimen. We have started a clinical trial with the objective of comparing the effectiveness of 1000 mg of ferric carboxymaltose with fractionated iron sucrose 200 g/48 h for the treatment of postoperative anaemia, by measuring the change of haemoglobin (Hb) levels from postoperative day (POD) 1 to POD 30. We designed an open label randomised controlled trial to compare two postoperative IVI treatment regimens. Patients aged
publishDate 2019
dc.date.none.fl_str_mv 2
2019-01-01
2019
2019-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/226292
https://dx.doi.org/urn:doi:10.1186/s13063-018-3125-2
url https://ddd.uab.cat/record/226292
https://dx.doi.org/urn:doi:10.1186/s13063-018-3125-2
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
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