Lacticaseibacillus rhamnosus GG improves behavior, immune functions, and biological age markers in female mice with premature aging

The data that support the findings of this study are available from the corresponding author upon reasonable request.

Detalles Bibliográficos
Autores: Díaz-Del Cerro, Estefanía, Félix-Escalera, Judith, Solo de Zaldívar Gálvez, Beatriz, Martínez-Cuesta, M. Carmen, Ceprián, Noemí, Requena, Teresa, Fuente, Mónica de la
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/399754
Acceso en línea:http://hdl.handle.net/10261/399754
Access Level:acceso abierto
Palabra clave:Lacticaseibacillus rhamnosus GG
Aging
Behavior
Immune functions
Longevity
Biological age
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spelling Lacticaseibacillus rhamnosus GG improves behavior, immune functions, and biological age markers in female mice with premature agingDíaz-Del Cerro, EstefaníaFélix-Escalera, JudithSolo de Zaldívar Gálvez, BeatrizMartínez-Cuesta, M. CarmenCeprián, NoemíRequena, TeresaFuente, Mónica de laLacticaseibacillus rhamnosus GGAgingBehaviorImmune functionsLongevityBiological ageThe data that support the findings of this study are available from the corresponding author upon reasonable request.[Background]: Prematurely aged mice (PAM), characterized by an inadequate stress response, exhibit early immunosenescence and reduced lifespan compared with exceptional non-PAM (E-NPAM) of the same age. Lacticaseibacillus rhamnosus GG (LGG) has been proposed as a beneficial probiotic in healthy aging. This study aimed to evaluate the effects of LGG consumption over 2 and 4 weeks on behavioral parameters, peritoneal leukocyte function, and lifespan in adult female PAM.[Results]: Female ICR-CD1 mice were classified as either PAM or E-NPAM and divided into three groups: (1) PAM control (PAMC), (2) PAM receiving LGG (PAMLGG), and (3) E-NPAM control (E-NPAMC). The PAMLGG group consumed a lyophilized LGG suspension in skim milk for 4 weeks, while the PAMC and E-NPAMC groups received a skim milk solution. Behavioral tests were conducted after 2 weeks, and leukocyte function was analyzed after 2 and 4 weeks. The results showed that the PAMLGG group exhibited improved behavioral responses and enhanced immune functions, which was reflected in a lower biological age and in a longer longevity compared with the PAMC.[Conclusion]: LGG supplementation positively influenced behavior, immune function, and biological age markers in female PAM, leading to increased longevity. These findings indicate that LGG administration could be a good nutritional strategy for slowing down the aging process, allowing a healthy longevity to be achieved.This work was supported by the Research Group UCM (910379) and FIS (PI15/01787) of the Health Institute Carlos III – Regional Developing Aid European Funds (ISCIII-FEDER), PID2022-136874OB-C31 and PID2022-136874OB-C32 (MICIU/AEI/10.13039/501100011033), and CDTI (INDEKA IDI-20190077 and SyBARIOTA IDI-20210293). We acknowledge Paula Hernández for technical support.Peer reviewedWiley-VCHInstituto de Salud Carlos IIIAgencia Estatal de Investigación (España)European CommissionMinisterio de Ciencia, Innovación y Universidades (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttp://hdl.handle.net/10261/399754reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-136874OA-C32info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-136874OB-C31https://doi.org/10.1002/jsfa.14219Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3997542026-05-22T06:33:51Z
dc.title.none.fl_str_mv Lacticaseibacillus rhamnosus GG improves behavior, immune functions, and biological age markers in female mice with premature aging
title Lacticaseibacillus rhamnosus GG improves behavior, immune functions, and biological age markers in female mice with premature aging
spellingShingle Lacticaseibacillus rhamnosus GG improves behavior, immune functions, and biological age markers in female mice with premature aging
Díaz-Del Cerro, Estefanía
Lacticaseibacillus rhamnosus GG
Aging
Behavior
Immune functions
Longevity
Biological age
title_short Lacticaseibacillus rhamnosus GG improves behavior, immune functions, and biological age markers in female mice with premature aging
title_full Lacticaseibacillus rhamnosus GG improves behavior, immune functions, and biological age markers in female mice with premature aging
title_fullStr Lacticaseibacillus rhamnosus GG improves behavior, immune functions, and biological age markers in female mice with premature aging
title_full_unstemmed Lacticaseibacillus rhamnosus GG improves behavior, immune functions, and biological age markers in female mice with premature aging
title_sort Lacticaseibacillus rhamnosus GG improves behavior, immune functions, and biological age markers in female mice with premature aging
dc.creator.none.fl_str_mv Díaz-Del Cerro, Estefanía
Félix-Escalera, Judith
Solo de Zaldívar Gálvez, Beatriz
Martínez-Cuesta, M. Carmen
Ceprián, Noemí
Requena, Teresa
Fuente, Mónica de la
author Díaz-Del Cerro, Estefanía
author_facet Díaz-Del Cerro, Estefanía
Félix-Escalera, Judith
Solo de Zaldívar Gálvez, Beatriz
Martínez-Cuesta, M. Carmen
Ceprián, Noemí
Requena, Teresa
Fuente, Mónica de la
author_role author
author2 Félix-Escalera, Judith
Solo de Zaldívar Gálvez, Beatriz
Martínez-Cuesta, M. Carmen
Ceprián, Noemí
Requena, Teresa
Fuente, Mónica de la
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Salud Carlos III
Agencia Estatal de Investigación (España)
European Commission
Ministerio de Ciencia, Innovación y Universidades (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Lacticaseibacillus rhamnosus GG
Aging
Behavior
Immune functions
Longevity
Biological age
topic Lacticaseibacillus rhamnosus GG
Aging
Behavior
Immune functions
Longevity
Biological age
description The data that support the findings of this study are available from the corresponding author upon reasonable request.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/399754
url http://hdl.handle.net/10261/399754
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-136874OA-C32
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-136874OB-C31
https://doi.org/10.1002/jsfa.14219
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley-VCH
publisher.none.fl_str_mv Wiley-VCH
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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