Novel genes involved in severe early-onset obesity revealed by rare copy number and sequence variants

Obesity is a multifactorial disorder with high heritability (50-75%), which is probably higher in early-onset and severe cases. Although rare monogenic forms and several genes and regions of susceptibility, including copy number variants (CNVs), have been described, the genetic causes underlying the...

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Detalles Bibliográficos
Autores: Serra-Juhe, Clara|||0000-0001-8471-8391, Martos-Moreno, Gabriel Á., Bou de Pieri, Francesc|||0000-0003-4006-7130, Flores, Raquel, González, Juan Ramón|||0000-0003-3267-2146, Rodriguez Santiago, Benjamin|||0000-0003-1167-3852, Argente, Jesús|||0000-0001-5826-0276, Pérez-Jurado, Luis Alberto|||0000-0002-1988-3005
Tipo de recurso: artículo
Fecha de publicación:2017
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:253886
Acceso en línea:https://ddd.uab.cat/record/253886
https://dx.doi.org/urn:doi:10.1371/journal.pgen.1006657
Access Level:acceso abierto
Descripción
Sumario:Obesity is a multifactorial disorder with high heritability (50-75%), which is probably higher in early-onset and severe cases. Although rare monogenic forms and several genes and regions of susceptibility, including copy number variants (CNVs), have been described, the genetic causes underlying the disease still remain largely unknown. We searched for rare CNVs (.

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