One-year changes in urinary microbial phenolic metabolites and the risk of type 2 diabetes: a case-control study

The intake of polyphenols has been associated with a risk reduction of type 2 diabetes. Nevertheless, to the best of our knowledge, the molecules that might be metabolically active after ingestion are only starting to be investigated regarding this metabolic disease. To investigate the association b...

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Autores: Marhuenda Muñoz, María, Domínguez-López, Inés, Laveriano-Santos, Emily P., Parilli-Moser, Isabella, Razquin, Cristina, Ruiz-Canela, Miguel, Basterra-Gortari, F. Javier, Salas-Salvadó, Jordi, Fitó Colomer, Montserrat, Lapetra, José, Arós, Fernando, Fiol, Miquel, Serra-Majem, Luis, Pintó Sala, Xavier, Gómez-Gracia, Enrique, Ros, Emilio, Estruch, Ramón, Lamuela Raventós, Rosa Ma.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/55274
Acceso en línea:http://hdl.handle.net/10230/55274
http://dx.doi.org/10.3390/antiox11081540
Access Level:acceso abierto
Palabra clave:Mediterranean diet
PREDIMED study
Bioactive compounds
Cardiovascular
Liquid chromatography
Mass spectrometry
Phytochemicals
Urinary microbial phenolic metabolites
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spelling One-year changes in urinary microbial phenolic metabolites and the risk of type 2 diabetes: a case-control studyMarhuenda Muñoz, MaríaDomínguez-López, InésLaveriano-Santos, Emily P.Parilli-Moser, IsabellaRazquin, CristinaRuiz-Canela, MiguelBasterra-Gortari, F. JavierSalas-Salvadó, JordiFitó Colomer, MontserratLapetra, JoséArós, FernandoFiol, MiquelSerra-Majem, LuisPintó Sala, XavierGómez-Gracia, EnriqueRos, EmilioEstruch, RamónLamuela Raventós, Rosa Ma.Mediterranean dietPREDIMED studyBioactive compoundsCardiovascularLiquid chromatographyMass spectrometryPhytochemicalsUrinary microbial phenolic metabolitesThe intake of polyphenols has been associated with a risk reduction of type 2 diabetes. Nevertheless, to the best of our knowledge, the molecules that might be metabolically active after ingestion are only starting to be investigated regarding this metabolic disease. To investigate the association between one-year changes in urinary microbial phenolic metabolites (MPM) and the incidence of type 2 diabetes, we performed a case-control study using data and samples of the PREDIMED trial including 46 incident type 2 diabetes cases of 172 randomly selected participants. Eight urinary MPMs were quantified in urine by liquid chromatography coupled to mass spectrometry and used to assess their associations with type 2 diabetes risk by multivariable logistic regression models. Compared to participants in the lowest tertile of one-year changes in hydroxybenzoic acid glucuronide, those in the highest tertile had a significantly lowered probability of developing type 2 diabetes (OR [95% CI], 0.39 [0.23-0.64]; p < 0.001 for trend). However, when additionally adjusting for fasting plasma glucose, the statistical significance was lost. Changes in the dietary pattern can increase the concentrations of this compound, derived from many (poly)phenol-rich foods, and might be changing the gut microbial population as well, promoting the production of the metabolite.This research was funded by CICYT [AGL2016-75329-R] PID2020-114022RB-I00, CIBEROBN Instituto de Salud Carlos III, ISCIII from the Ministerio de Ciencia, Innovación y Universidades, (AEI/FEDER 10.13039/501100011033, UE), and Generalitat de Catalunya (GC) [2017SGR196]. M.M.-M. is supported by the FPU17/00513 grant. I.D.-L. thanks the Spanish Ministry of Science Innovation and Universities for the Formación de Profesorado Universitario (FPU20/02478) contract. E.P.L.-S. is supported by the FI-SDUR (EM/3345/2020) grant from the Generalitat de Catalunya. I.P.-M. is supported by the FI-SDUR (EMC/2703/2019).MDPI202320232022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/55274http://dx.doi.org/10.3390/antiox11081540reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésinfo:eu-repo/grantAgreement/ES/1PE/AGL2016-75329-Rinfo:eu-repo/grantAgreement/ES/2PE/PID2020-114022RB-I00© Marhuenda-Muñoz M, Domínguez-López I, Laveriano-Santos EP, Parilli-Moser I, Razquin C, Ruiz-Canela M, et al.. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/552742026-05-29T05:05:01Z
dc.title.none.fl_str_mv One-year changes in urinary microbial phenolic metabolites and the risk of type 2 diabetes: a case-control study
title One-year changes in urinary microbial phenolic metabolites and the risk of type 2 diabetes: a case-control study
spellingShingle One-year changes in urinary microbial phenolic metabolites and the risk of type 2 diabetes: a case-control study
Marhuenda Muñoz, María
Mediterranean diet
PREDIMED study
Bioactive compounds
Cardiovascular
Liquid chromatography
Mass spectrometry
Phytochemicals
Urinary microbial phenolic metabolites
title_short One-year changes in urinary microbial phenolic metabolites and the risk of type 2 diabetes: a case-control study
title_full One-year changes in urinary microbial phenolic metabolites and the risk of type 2 diabetes: a case-control study
title_fullStr One-year changes in urinary microbial phenolic metabolites and the risk of type 2 diabetes: a case-control study
title_full_unstemmed One-year changes in urinary microbial phenolic metabolites and the risk of type 2 diabetes: a case-control study
title_sort One-year changes in urinary microbial phenolic metabolites and the risk of type 2 diabetes: a case-control study
dc.creator.none.fl_str_mv Marhuenda Muñoz, María
Domínguez-López, Inés
Laveriano-Santos, Emily P.
Parilli-Moser, Isabella
Razquin, Cristina
Ruiz-Canela, Miguel
Basterra-Gortari, F. Javier
Salas-Salvadó, Jordi
Fitó Colomer, Montserrat
Lapetra, José
Arós, Fernando
Fiol, Miquel
Serra-Majem, Luis
Pintó Sala, Xavier
Gómez-Gracia, Enrique
Ros, Emilio
Estruch, Ramón
Lamuela Raventós, Rosa Ma.
author Marhuenda Muñoz, María
author_facet Marhuenda Muñoz, María
Domínguez-López, Inés
Laveriano-Santos, Emily P.
Parilli-Moser, Isabella
Razquin, Cristina
Ruiz-Canela, Miguel
Basterra-Gortari, F. Javier
Salas-Salvadó, Jordi
Fitó Colomer, Montserrat
Lapetra, José
Arós, Fernando
Fiol, Miquel
Serra-Majem, Luis
Pintó Sala, Xavier
Gómez-Gracia, Enrique
Ros, Emilio
Estruch, Ramón
Lamuela Raventós, Rosa Ma.
author_role author
author2 Domínguez-López, Inés
Laveriano-Santos, Emily P.
Parilli-Moser, Isabella
Razquin, Cristina
Ruiz-Canela, Miguel
Basterra-Gortari, F. Javier
Salas-Salvadó, Jordi
Fitó Colomer, Montserrat
Lapetra, José
Arós, Fernando
Fiol, Miquel
Serra-Majem, Luis
Pintó Sala, Xavier
Gómez-Gracia, Enrique
Ros, Emilio
Estruch, Ramón
Lamuela Raventós, Rosa Ma.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Mediterranean diet
PREDIMED study
Bioactive compounds
Cardiovascular
Liquid chromatography
Mass spectrometry
Phytochemicals
Urinary microbial phenolic metabolites
topic Mediterranean diet
PREDIMED study
Bioactive compounds
Cardiovascular
Liquid chromatography
Mass spectrometry
Phytochemicals
Urinary microbial phenolic metabolites
description The intake of polyphenols has been associated with a risk reduction of type 2 diabetes. Nevertheless, to the best of our knowledge, the molecules that might be metabolically active after ingestion are only starting to be investigated regarding this metabolic disease. To investigate the association between one-year changes in urinary microbial phenolic metabolites (MPM) and the incidence of type 2 diabetes, we performed a case-control study using data and samples of the PREDIMED trial including 46 incident type 2 diabetes cases of 172 randomly selected participants. Eight urinary MPMs were quantified in urine by liquid chromatography coupled to mass spectrometry and used to assess their associations with type 2 diabetes risk by multivariable logistic regression models. Compared to participants in the lowest tertile of one-year changes in hydroxybenzoic acid glucuronide, those in the highest tertile had a significantly lowered probability of developing type 2 diabetes (OR [95% CI], 0.39 [0.23-0.64]; p < 0.001 for trend). However, when additionally adjusting for fasting plasma glucose, the statistical significance was lost. Changes in the dietary pattern can increase the concentrations of this compound, derived from many (poly)phenol-rich foods, and might be changing the gut microbial population as well, promoting the production of the metabolite.
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/55274
http://dx.doi.org/10.3390/antiox11081540
url http://hdl.handle.net/10230/55274
http://dx.doi.org/10.3390/antiox11081540
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/ES/1PE/AGL2016-75329-R
info:eu-repo/grantAgreement/ES/2PE/PID2020-114022RB-I00
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
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