A genome-wide association meta-analysis of all-cause and vascular dementia

Methods: We conducted a GWAS of all-cause dementia (ACD) and examined the genetic overlap with VaD. Our dataset includes 800,597 individuals, with 46,902 and 8702 cases of ACD and VaD, respectively. Known AD loci for ACD and VaD were replicated. Bioinformatic analyses prioritized genes that are like...

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Detalles Bibliográficos
Autores: Fongang, Bernard, Sargurupremraj, Muralidharan, Jian, Xueqiu, Mishra, Aniket, Damotte, Vincent, Rojas, Itiziar de, Skrobot, Olivia, Bis, Joshua C., Fan, Kang-Hsien, Jacobsen, Erin, Li, Gloria Hoi-Yee, Yan, Jingyun, Alessandra, Bizzarro, Alessandra, Lauria, Hilal, Saima, Chong, Joyce Ruifen, Chai, Yuek Ling, Knol, M. J., Rodríguez Rodríguez, Eloy Manuel
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universidad de Cantabria (UC)
Repositorio:UCrea Repositorio Abierto de la Universidad de Cantabria
Idioma:inglés
OAI Identifier:oai:repositorio.unican.es:10902/35133
Acceso en línea:https://hdl.handle.net/10902/35133
Access Level:acceso abierto
Palabra clave:All-cause dementia
Alzheimer’s disease
Cross-ancestry
Genome-wide association study (GWAS)
GWAS meta-analysis
Vascular dementia
Descripción
Sumario:Methods: We conducted a GWAS of all-cause dementia (ACD) and examined the genetic overlap with VaD. Our dataset includes 800,597 individuals, with 46,902 and 8702 cases of ACD and VaD, respectively. Known AD loci for ACD and VaD were replicated. Bioinformatic analyses prioritized genes that are likely functionally relevant and shared with closely related traits and risk factors. Results: For ACD, novel loci identified were associated with energy transport (SEMA4D), neuronal excitability (ANO3), amyloid deposition in the brain (RBFOX1), and magnetic resonance imaging markers of small vessel disease (SVD; HBEGF). Novel VaD loci were associated with hypertension, diabetes, and neuron maintenance (SPRY2, FOXA2, AJAP1, and PSMA3). Discussion: Our study identified genetic risks underlying ACD, demonstrating overlap with neurodegenerative processes, vascular risk factors, and cerebral SVD.

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