Hair cortisol level as a molecular biomarker in retinitis pigmentosa patients

Producción Científica

Detalles Bibliográficos
Autores: Mateos Olivares, Milagros, Sobas Abad, Eva María, Puertas Neyra, Kevin Louis, Peralta Ramírez, María Isabel, González Pérez, Raquel, Martín Vallejo, Javier, García Vázquez, Carmen, Coco Martín, Rosa María, Pastor Jimeno, José Carlos, Pastor Idoate, Salvador, Usategui Martín, Ricardo
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universidad de Valladolid
Repositorio:UVaDOC. Repositorio Documental de la Universidad de Valladolid
OAI Identifier:oai:uvadoc.uva.es:10324/53072
Acceso en línea:https://doi.org/10.1016/j.exer.2022.109019
https://uvadoc.uva.es/handle/10324/53072
Access Level:acceso abierto
Palabra clave:Retinitis pigmentosa
Hair cortisol
Pelo - Cortisol
Molecular biomarkers
Biomarcadores moleculares
id ES_efdeaa07605f2cd5221be77dcb970118
oai_identifier_str oai:uvadoc.uva.es:10324/53072
network_acronym_str ES
network_name_str España
repository_id_str
spelling Hair cortisol level as a molecular biomarker in retinitis pigmentosa patientsMateos Olivares, MilagrosSobas Abad, Eva MaríaPuertas Neyra, Kevin LouisPeralta Ramírez, María IsabelGonzález Pérez, RaquelMartín Vallejo, JavierGarcía Vázquez, CarmenCoco Martín, Rosa MaríaPastor Jimeno, José CarlosPastor Idoate, SalvadorUsategui Martín, RicardoRetinitis pigmentosaHair cortisolPelo - CortisolMolecular biomarkersBiomarcadores molecularesProducción CientíficaPurpose: Retinitis pigmentosa (RP) patients commonly experience negative psychological states due to their progressive and unpredictable loss of vision and visual variations related to stress. The aim of this study was to examine hair cortisol concentrations (HCCs), which is usually associated with chronic stress, pretending to unveil possible associations between underlying psychological factors and disease severity in RP patients. Methods: Seventy-eight RP patients and 148 healthy controls were included in this study. A complete ophthalmological exam was performed in all patients to grade into severity disease groups. Perceived stress and trait-anxiety were measured by the State-Trait Anxiety Inventory (STAI) questionnaire. Results: Fifty-two (67%) patients had severe RP and 26 (33%) mild-moderate RP. Fifty-eight (58,9%) patients reported severely levels of stress and 18 (23.,1%) highly levels assessed by STAI questionnaire. RP patients exhibited higher HCCs (500.04 ± 120.99 pg/mg) than in controls (136.17 ± 60.51 pg/mg; p < 0.001). Severe RP patients had significant higher HCCs than mild-moderate patients differing in 274.27 pg/mg (p < 0.001). RP severity grade and perceived anxiety levels in the questionaries were not associated. Group differences were not affected by relevant covariates (age, grade of severity, stress status, and gender). Conclusions: HCC seems an effective biomarker associated with chronic stress in RP patients. This study shows that HCC in patients with RP are elevated compared to population-based controls, and association between HCC and RP severity was found. Future research is needed to characterize the effect of untreated negative psychological states on progression of the disease if any.Gerencia Regional de Salud de Castilla y León (GRS, 1932/A/19)Ministerio de Ciencia, Innovación y Universidades (grant PID2020-114585RA-I00)Elsevier2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.1016/j.exer.2022.109019https://uvadoc.uva.es/handle/10324/53072reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolidinstname:Universidad de ValladolidIngléshttps://www.sciencedirect.com/science/article/pii/S0014483522001002info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:uvadoc.uva.es:10324/530722026-06-13T12:44:47Z
dc.title.none.fl_str_mv Hair cortisol level as a molecular biomarker in retinitis pigmentosa patients
title Hair cortisol level as a molecular biomarker in retinitis pigmentosa patients
spellingShingle Hair cortisol level as a molecular biomarker in retinitis pigmentosa patients
Mateos Olivares, Milagros
Retinitis pigmentosa
Hair cortisol
Pelo - Cortisol
Molecular biomarkers
Biomarcadores moleculares
title_short Hair cortisol level as a molecular biomarker in retinitis pigmentosa patients
title_full Hair cortisol level as a molecular biomarker in retinitis pigmentosa patients
title_fullStr Hair cortisol level as a molecular biomarker in retinitis pigmentosa patients
title_full_unstemmed Hair cortisol level as a molecular biomarker in retinitis pigmentosa patients
title_sort Hair cortisol level as a molecular biomarker in retinitis pigmentosa patients
dc.creator.none.fl_str_mv Mateos Olivares, Milagros
Sobas Abad, Eva María
Puertas Neyra, Kevin Louis
Peralta Ramírez, María Isabel
González Pérez, Raquel
Martín Vallejo, Javier
García Vázquez, Carmen
Coco Martín, Rosa María
Pastor Jimeno, José Carlos
Pastor Idoate, Salvador
Usategui Martín, Ricardo
author Mateos Olivares, Milagros
author_facet Mateos Olivares, Milagros
Sobas Abad, Eva María
Puertas Neyra, Kevin Louis
Peralta Ramírez, María Isabel
González Pérez, Raquel
Martín Vallejo, Javier
García Vázquez, Carmen
Coco Martín, Rosa María
Pastor Jimeno, José Carlos
Pastor Idoate, Salvador
Usategui Martín, Ricardo
author_role author
author2 Sobas Abad, Eva María
Puertas Neyra, Kevin Louis
Peralta Ramírez, María Isabel
González Pérez, Raquel
Martín Vallejo, Javier
García Vázquez, Carmen
Coco Martín, Rosa María
Pastor Jimeno, José Carlos
Pastor Idoate, Salvador
Usategui Martín, Ricardo
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Retinitis pigmentosa
Hair cortisol
Pelo - Cortisol
Molecular biomarkers
Biomarcadores moleculares
topic Retinitis pigmentosa
Hair cortisol
Pelo - Cortisol
Molecular biomarkers
Biomarcadores moleculares
description Producción Científica
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1016/j.exer.2022.109019
https://uvadoc.uva.es/handle/10324/53072
url https://doi.org/10.1016/j.exer.2022.109019
https://uvadoc.uva.es/handle/10324/53072
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://www.sciencedirect.com/science/article/pii/S0014483522001002
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname:Universidad de Valladolid
instname_str Universidad de Valladolid
reponame_str UVaDOC. Repositorio Documental de la Universidad de Valladolid
collection UVaDOC. Repositorio Documental de la Universidad de Valladolid
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869423903566200832
score 15,300719

Similares en LA Referencia