Gut microbiome and anti-viral immunity in COVID-19

SARS-CoV-2 mainly affects the respiratory system, but the gastrointestinal tract is also a target. Prolonged gut disorders, in COVID-19 patients, were correlated with decreased richness and diversity of the gut microbiota, immune deregulation and delayed viral clearance. Although there are no defini...

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Detalles Bibliográficos
Autores: Rossini, Valerio, Tolosa Enguís, Verónica, Francés Cuesta, Carlos, Sanz Herranz, Yolanda
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/296891
Acceso en línea:http://hdl.handle.net/10261/296891
https://api.elsevier.com/content/abstract/scopus_id/85142142632
Access Level:acceso abierto
Palabra clave:COVID-19
Gut microbiota
Host-microbiota interaction
Immunity
Microbiome
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spelling Gut microbiome and anti-viral immunity in COVID-19Rossini, ValerioTolosa Enguís, VerónicaFrancés Cuesta, CarlosSanz Herranz, YolandaCOVID-19Gut microbiotaHost-microbiota interactionImmunityMicrobiomeSARS-CoV-2 mainly affects the respiratory system, but the gastrointestinal tract is also a target. Prolonged gut disorders, in COVID-19 patients, were correlated with decreased richness and diversity of the gut microbiota, immune deregulation and delayed viral clearance. Although there are no definitive conclusions, ample evidence would suggest that the gut microbiome composition and function play a role in COVID-19 progression. Microbiome modulation strategies for population stratification and management of COVID-19 infection are under investigation, representing an area of interest in the ongoing pandemic. In this review, we present the existing data related to the interaction between gut microbes and the host's immune response to SARS-CoV-2 and discuss the implications for current disease management and readiness to face future pandemics.This work was supported by the European Commission – NextGenerationEU (Regulation EU 2020/2094) through CSIC’s Global Health Platform (PTI Salud Global).Peer reviewedTaylor & FrancisEuropean CommissionConsejo Superior de Investigaciones Científicas (España)Sanz Herranz, Yolanda [0000-0002-1615-1976]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202320232022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/296891https://api.elsevier.com/content/abstract/scopus_id/85142142632reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésCritical reviews in food science and nutritionhttps://doi.org/10.1080/10408398.2022.2143476Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2968912026-05-22T06:33:51Z
dc.title.none.fl_str_mv Gut microbiome and anti-viral immunity in COVID-19
title Gut microbiome and anti-viral immunity in COVID-19
spellingShingle Gut microbiome and anti-viral immunity in COVID-19
Rossini, Valerio
COVID-19
Gut microbiota
Host-microbiota interaction
Immunity
Microbiome
title_short Gut microbiome and anti-viral immunity in COVID-19
title_full Gut microbiome and anti-viral immunity in COVID-19
title_fullStr Gut microbiome and anti-viral immunity in COVID-19
title_full_unstemmed Gut microbiome and anti-viral immunity in COVID-19
title_sort Gut microbiome and anti-viral immunity in COVID-19
dc.creator.none.fl_str_mv Rossini, Valerio
Tolosa Enguís, Verónica
Francés Cuesta, Carlos
Sanz Herranz, Yolanda
author Rossini, Valerio
author_facet Rossini, Valerio
Tolosa Enguís, Verónica
Francés Cuesta, Carlos
Sanz Herranz, Yolanda
author_role author
author2 Tolosa Enguís, Verónica
Francés Cuesta, Carlos
Sanz Herranz, Yolanda
author2_role author
author
author
dc.contributor.none.fl_str_mv European Commission
Consejo Superior de Investigaciones Científicas (España)
Sanz Herranz, Yolanda [0000-0002-1615-1976]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv COVID-19
Gut microbiota
Host-microbiota interaction
Immunity
Microbiome
topic COVID-19
Gut microbiota
Host-microbiota interaction
Immunity
Microbiome
description SARS-CoV-2 mainly affects the respiratory system, but the gastrointestinal tract is also a target. Prolonged gut disorders, in COVID-19 patients, were correlated with decreased richness and diversity of the gut microbiota, immune deregulation and delayed viral clearance. Although there are no definitive conclusions, ample evidence would suggest that the gut microbiome composition and function play a role in COVID-19 progression. Microbiome modulation strategies for population stratification and management of COVID-19 infection are under investigation, representing an area of interest in the ongoing pandemic. In this review, we present the existing data related to the interaction between gut microbes and the host's immune response to SARS-CoV-2 and discuss the implications for current disease management and readiness to face future pandemics.
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/296891
https://api.elsevier.com/content/abstract/scopus_id/85142142632
url http://hdl.handle.net/10261/296891
https://api.elsevier.com/content/abstract/scopus_id/85142142632
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Critical reviews in food science and nutrition
https://doi.org/10.1080/10408398.2022.2143476
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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