Chronic treatment with acetaminophen protects against liver aging by targeting inflammation and oxidative stress

28 páginas, 7 figuras, 2 tablas

Detalhes bibliográficos
Autores: Brea, Rocío, Valdecantos, Pilar, Rada, Patricia, Alén, Rosa, García-Monzón, Carmelo, Boscá, Lisardo, Fuertes-Agudo, Marina, Casado, Marta, Martín-Sanz, Paloma, Valverde, Ángela M.
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2021
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositório:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/238682
Acesso em linha:http://hdl.handle.net/10261/238682
Access Level:Acceso aberto
Palavra-chave:APAP
Aging
Inflammation
Liver
Oxidative stress
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spelling Chronic treatment with acetaminophen protects against liver aging by targeting inflammation and oxidative stressBrea, RocíoValdecantos, PilarRada, PatriciaAlén, RosaGarcía-Monzón, CarmeloBoscá, LisardoFuertes-Agudo, MarinaCasado, MartaMartín-Sanz, PalomaValverde, Ángela M.APAPAgingInflammationLiverOxidative stress28 páginas, 7 figuras, 2 tablasThe liver exhibits a variety of functions that are well-preserved during aging. However, the cellular hallmarks of aging increase the risk of hepatic alterations and development of chronic liver diseases. Acetaminophen (APAP) is a first choice for relieving mild-to-moderate pain. Most of the knowledge about APAP-mediated hepatotoxicity arises from acute overdose studies due to massive oxidative stress and inflammation, but little is known about its effect in age-related liver inflammation after chronic exposure. Our results show that chronic treatment of wild-type mice on the B6D2JRcc/Hsd genetic background with APAP at an infratherapeutic dose reduces liver alterations during aging without affecting body weight. This intervention attenuates age-induced mild oxidative stress by increasing HO-1, MnSOD and NQO1 protein levels and reducing ERK1/2 and p38 MAPK phosphorylation. More importantly, APAP treatment counteracts the increase in Cd8+ and the reduction in Cd4+ T lymphocytes observed in the liver with age. This response was also found in peripheral blood mononuclear cells. In conclusion, chronic infratherapeutic APAP treatment protects mice from age-related liver alterations by attenuating oxidative stress and inflammation.SAF2016-75004-R, PID2019-108977RB-100 (AEI/FEDER, UE) to P. M-S. and M.C. and S2017/BMD-3686 (CM) to P. M-S, RTI2018-094052-B-100 (AEI/FEDER, UE), S2017/BMD-3684 (CM), Fundación Ramón Areces (Spain) and CIBERdem (ISCIII) to A.M.V., and PI17/00535 (ISCIII/FEDER, UE) to C. G-M.Peer reviewedImpact JournalsMinisterio de Ciencia, Innovación y Universidades (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202120212021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/238682reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2016-75004-Rinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-108977RB-100https://dx.doi.org/10.18632/aging.202884Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2386822026-05-22T06:33:51Z
dc.title.none.fl_str_mv Chronic treatment with acetaminophen protects against liver aging by targeting inflammation and oxidative stress
title Chronic treatment with acetaminophen protects against liver aging by targeting inflammation and oxidative stress
spellingShingle Chronic treatment with acetaminophen protects against liver aging by targeting inflammation and oxidative stress
Brea, Rocío
APAP
Aging
Inflammation
Liver
Oxidative stress
title_short Chronic treatment with acetaminophen protects against liver aging by targeting inflammation and oxidative stress
title_full Chronic treatment with acetaminophen protects against liver aging by targeting inflammation and oxidative stress
title_fullStr Chronic treatment with acetaminophen protects against liver aging by targeting inflammation and oxidative stress
title_full_unstemmed Chronic treatment with acetaminophen protects against liver aging by targeting inflammation and oxidative stress
title_sort Chronic treatment with acetaminophen protects against liver aging by targeting inflammation and oxidative stress
dc.creator.none.fl_str_mv Brea, Rocío
Valdecantos, Pilar
Rada, Patricia
Alén, Rosa
García-Monzón, Carmelo
Boscá, Lisardo
Fuertes-Agudo, Marina
Casado, Marta
Martín-Sanz, Paloma
Valverde, Ángela M.
author Brea, Rocío
author_facet Brea, Rocío
Valdecantos, Pilar
Rada, Patricia
Alén, Rosa
García-Monzón, Carmelo
Boscá, Lisardo
Fuertes-Agudo, Marina
Casado, Marta
Martín-Sanz, Paloma
Valverde, Ángela M.
author_role author
author2 Valdecantos, Pilar
Rada, Patricia
Alén, Rosa
García-Monzón, Carmelo
Boscá, Lisardo
Fuertes-Agudo, Marina
Casado, Marta
Martín-Sanz, Paloma
Valverde, Ángela M.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv APAP
Aging
Inflammation
Liver
Oxidative stress
topic APAP
Aging
Inflammation
Liver
Oxidative stress
description 28 páginas, 7 figuras, 2 tablas
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/238682
url http://hdl.handle.net/10261/238682
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2016-75004-R
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-108977RB-100
https://dx.doi.org/10.18632/aging.202884
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Impact Journals
publisher.none.fl_str_mv Impact Journals
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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