Childhood maltreatment disrupts HPA-axis activity under basal and stress conditions in a dose-response relationship in children and adolescents

Background. This study investigates the impact of childhood maltreatment (CM) on hypo- thalamic-pituitary-adrenal (HPA)-axis functioning and on anxiety perception. Moreover, the influence of CM severity and frequency was also explored. Methods. In total, 187 participants aged 7-17 were assessed for...

Descripción completa

Detalles Bibliográficos
Autores: Marques Feixa, Laia, Palma Gudiel, Helena, Romero, Soledad, Moya Higueras, Jorge, Rapado Castro, Marta, Castro Quintas, Águeda, Zorrilla, Iñaki, Muñoz, María José, Ramírez, Maite, Mayoral, María, Mas, Ariadna, Lobato, María José, Blasco Fontecilla, Hilario, Fañanás Saura, Lourdes, EPI-Young Stress GROUP
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10459.1/71768
Acceso en línea:https://doi.org/10.1017/S003329172100249X
http://hdl.handle.net/10459.1/71768
Access Level:acceso abierto
Palabra clave:Anxiety perception
Childhood maltreatment
Trier Social Stress Test for Children (TSST-C)
Cortisol
Psychopathology and mental disorders
id ES_efd35b8f71a9b6b13d5a7cd2d47e30c4
oai_identifier_str oai:recercat.cat:10459.1/71768
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Childhood maltreatment disrupts HPA-axis activity under basal and stress conditions in a dose-response relationship in children and adolescents
title Childhood maltreatment disrupts HPA-axis activity under basal and stress conditions in a dose-response relationship in children and adolescents
spellingShingle Childhood maltreatment disrupts HPA-axis activity under basal and stress conditions in a dose-response relationship in children and adolescents
Marques Feixa, Laia
Anxiety perception
Childhood maltreatment
Trier Social Stress Test for Children (TSST-C)
Cortisol
Psychopathology and mental disorders
title_short Childhood maltreatment disrupts HPA-axis activity under basal and stress conditions in a dose-response relationship in children and adolescents
title_full Childhood maltreatment disrupts HPA-axis activity under basal and stress conditions in a dose-response relationship in children and adolescents
title_fullStr Childhood maltreatment disrupts HPA-axis activity under basal and stress conditions in a dose-response relationship in children and adolescents
title_full_unstemmed Childhood maltreatment disrupts HPA-axis activity under basal and stress conditions in a dose-response relationship in children and adolescents
title_sort Childhood maltreatment disrupts HPA-axis activity under basal and stress conditions in a dose-response relationship in children and adolescents
dc.creator.none.fl_str_mv Marques Feixa, Laia
Palma Gudiel, Helena
Romero, Soledad
Moya Higueras, Jorge
Rapado Castro, Marta
Castro Quintas, Águeda
Zorrilla, Iñaki
Muñoz, María José
Ramírez, Maite
Mayoral, María
Mas, Ariadna
Lobato, María José
Blasco Fontecilla, Hilario
Fañanás Saura, Lourdes
EPI-Young Stress GROUP
author Marques Feixa, Laia
author_facet Marques Feixa, Laia
Palma Gudiel, Helena
Romero, Soledad
Moya Higueras, Jorge
Rapado Castro, Marta
Castro Quintas, Águeda
Zorrilla, Iñaki
Muñoz, María José
Ramírez, Maite
Mayoral, María
Mas, Ariadna
Lobato, María José
Blasco Fontecilla, Hilario
Fañanás Saura, Lourdes
EPI-Young Stress GROUP
author_role author
author2 Palma Gudiel, Helena
Romero, Soledad
Moya Higueras, Jorge
Rapado Castro, Marta
Castro Quintas, Águeda
Zorrilla, Iñaki
Muñoz, María José
Ramírez, Maite
Mayoral, María
Mas, Ariadna
Lobato, María José
Blasco Fontecilla, Hilario
Fañanás Saura, Lourdes
EPI-Young Stress GROUP
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Anxiety perception
Childhood maltreatment
Trier Social Stress Test for Children (TSST-C)
Cortisol
Psychopathology and mental disorders
topic Anxiety perception
Childhood maltreatment
Trier Social Stress Test for Children (TSST-C)
Cortisol
Psychopathology and mental disorders
description Background. This study investigates the impact of childhood maltreatment (CM) on hypo- thalamic-pituitary-adrenal (HPA)-axis functioning and on anxiety perception. Moreover, the influence of CM severity and frequency was also explored. Methods. In total, 187 participants aged 7-17 were assessed for CM history using validated questionnaires and ad hoc interviews to be classified according to the criteria of the Tool for Assessing the Severity of Situations in which Children are Vulnerable (TASSCV). Psychopathology was ascertained using the K-SADS-PL5. To assess HPA-axis functioning, salivary cortisol samples were collected throughout a normal day and during an acute psycho- social stressor, the Trier Social Stress Test for children (TSST-C). Subjective anxiety was evaluated using STAI/-C. Results. Youth with a CM history had higher overall diurnal cortisol levels (p=0.001), blunted cortisol response to acute psychosocial stress ( p = 0.002) and greater perceived anx- iety ( p = 0.003), than those without CM. Specifically, participants exposed to moderate/severe or often/frequent CM showed the greater diurnal cortisol output ( pseverity = 0.002; pfrequency = 0.003), and blunted cortisol response during the TSST-C ( pseverity = 0.006; pfrequency = 0.008). Meanwhile, youth with low CM severity/frequency exhibited a similar cortisol response to those without CM. However, perceived anxiety was higher in those exposed to CM ( p < 0.001), regardless of its severity/frequency. Conclusions. Disturbances in HPA-axis functioning are already evident early after CM expos- ure, while psychological and physiological responses to an acute stressor are dissociated in youth exposed to CM. The dose-response relationship described in this paper highlights the need to comprehensively evaluate CM so that vulnerable children can be identified and assigned to proper interventions.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1017/S003329172100249X
http://hdl.handle.net/10459.1/71768
http://hdl.handle.net/10459.1/71768
url https://doi.org/10.1017/S003329172100249X
http://hdl.handle.net/10459.1/71768
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a https://doi.org/10.1017/S003329172100249X
Psychological Medicine, 2021, p. 1-14
dc.rights.none.fl_str_mv cc-by (c) Marques et al., 2021
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/es/
rights_invalid_str_mv cc-by (c) Marques et al., 2021
http://creativecommons.org/licenses/by/4.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Cambridge University Press
publisher.none.fl_str_mv Cambridge University Press
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869423899401256960
spelling Childhood maltreatment disrupts HPA-axis activity under basal and stress conditions in a dose-response relationship in children and adolescentsMarques Feixa, LaiaPalma Gudiel, HelenaRomero, SoledadMoya Higueras, JorgeRapado Castro, MartaCastro Quintas, ÁguedaZorrilla, IñakiMuñoz, María JoséRamírez, MaiteMayoral, MaríaMas, AriadnaLobato, María JoséBlasco Fontecilla, HilarioFañanás Saura, LourdesEPI-Young Stress GROUPAnxiety perceptionChildhood maltreatmentTrier Social Stress Test for Children (TSST-C)CortisolPsychopathology and mental disordersBackground. This study investigates the impact of childhood maltreatment (CM) on hypo- thalamic-pituitary-adrenal (HPA)-axis functioning and on anxiety perception. Moreover, the influence of CM severity and frequency was also explored. Methods. In total, 187 participants aged 7-17 were assessed for CM history using validated questionnaires and ad hoc interviews to be classified according to the criteria of the Tool for Assessing the Severity of Situations in which Children are Vulnerable (TASSCV). Psychopathology was ascertained using the K-SADS-PL5. To assess HPA-axis functioning, salivary cortisol samples were collected throughout a normal day and during an acute psycho- social stressor, the Trier Social Stress Test for children (TSST-C). Subjective anxiety was evaluated using STAI/-C. Results. Youth with a CM history had higher overall diurnal cortisol levels (p=0.001), blunted cortisol response to acute psychosocial stress ( p = 0.002) and greater perceived anx- iety ( p = 0.003), than those without CM. Specifically, participants exposed to moderate/severe or often/frequent CM showed the greater diurnal cortisol output ( pseverity = 0.002; pfrequency = 0.003), and blunted cortisol response during the TSST-C ( pseverity = 0.006; pfrequency = 0.008). Meanwhile, youth with low CM severity/frequency exhibited a similar cortisol response to those without CM. However, perceived anxiety was higher in those exposed to CM ( p < 0.001), regardless of its severity/frequency. Conclusions. Disturbances in HPA-axis functioning are already evident early after CM expos- ure, while psychological and physiological responses to an acute stressor are dissociated in youth exposed to CM. The dose-response relationship described in this paper highlights the need to comprehensively evaluate CM so that vulnerable children can be identified and assigned to proper interventions.Supported by the Spanish Ministry of Economy and Competitiveness, Instituto de Salud Carlos III through the University of Barcelona multicenter project (PI15/00097)-PI L. Fañanas, Hospital Universitario Araba (PI15/00793)-PI I. Zorrilla, Hospital Gregorio Marañón (PI15/00723)-PI M. Rapado and Hospital Clinic (PI15/00685)-PI S. Romero, co-financed by the European Regional Development Fund project, ‘A way of making Europe’. We thank the Network Centre for Biomedical Research in Mental Health (CIBERSAM). This study was facilitated by a pre-doctoral research grant from the Catalonian authorities to Laia Marques-Feixa (AGAUR-FI_B100023-2018). Supported by a NARSAD Distinguished Investigator Grant awarded to Professor Lourdes Fañanas (26887) and by the Comissionat per a Universitats i Recerca del DIUE, of the Generalitat de Catalunya regional authorities (2017SGR1577). Dr Rapado-Castro was supported by a Ramon y Cajal Research Fellowship (RYC-2017-23144), Spanish Ministry of Science, Innovation and Universities; an NARSAD independent investigator grant (24628) from the Brain & Behaviour Research Foundation; Fundación Familia Alonso and Fundación Alicia Koplowitz.Cambridge University Press2021202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.1017/S003329172100249Xhttp://hdl.handle.net/10459.1/71768http://hdl.handle.net/10459.1/71768reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a https://doi.org/10.1017/S003329172100249XPsychological Medicine, 2021, p. 1-14cc-by (c) Marques et al., 2021info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/es/oai:recercat.cat:10459.1/717682026-05-29T05:05:01Z
score 15,812455

Similares en LA Referencia