Modulating grid cell scale and intrinsic frequencies via slow high-threshold conductances: A simplified model

Grid cells in the medial entorhinal cortex (MEC) have known spatial periodic firing fields which provide a metric for the representation of self-location and path planning. The hexagonal tessellation pattern of grid cells scales up progressively along the MEC’s layer II dorsal-to-ventral axis. This...

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Authors: Santos-Pata, Diogo, Zucca, Riccardo, López-Carral, Héctor, Verschure, Paul
Format: article
Status:Versión aceptada para publicación
Publication Date:2019
Country:España
Institution:Universidad de Barcelona
Repository:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/164298
Online Access:https://hdl.handle.net/2445/164298
Access Level:Open access
Keyword:Escorça cerebral
Neurones
Orientació animal
Cerebral cortex
Neurons
Animal orientation
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spelling Modulating grid cell scale and intrinsic frequencies via slow high-threshold conductances: A simplified modelSantos-Pata, DiogoZucca, RiccardoLópez-Carral, HéctorVerschure, PaulEscorça cerebralNeuronesOrientació animalCerebral cortexNeuronsAnimal orientationGrid cells in the medial entorhinal cortex (MEC) have known spatial periodic firing fields which provide a metric for the representation of self-location and path planning. The hexagonal tessellation pattern of grid cells scales up progressively along the MEC’s layer II dorsal-to-ventral axis. This scaling gradient has been hypothesized to originate either from inter-population synaptic dynamics as postulated by attractor networks, or from projected theta frequency waves to different axis levels, as in oscillatory models. Alternatively, cellular dynamics and specifically slow high-threshold conductances have been proposed to have an impact on the grid cell scale. To test the hypothesis that intrinsic hyperpolarization-activated cation currents account for both the scaled gradient and the oscillatory frequencies observed along the dorsal-to-ventral axis, we have modeled and analyzed data from a population of grid cells simulated with spiking neurons interacting through low-dimensional attractor dynamics. We observed that the intrinsic neuronal membrane properties of simulated cells were sufficient to induce an increase in grid scale and potentiate differences in the membrane potential oscillatory frequency. Overall, our results suggest that the after-spike dynamics of cation currents may play a major role in determining the grid cells’ scale and that oscillatory frequencies are a consequence of intrinsic cellular properties that are specific to different levels of the dorsal-to-ventral axis in the MEC layer II.Elsevier2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/164298Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1016/j.neunet.2019.06.011Neural Networks, 2019, vol. 119, p. 66-73https://doi.org/10.1016/j.neunet.2019.06.011info:eu-repo/grantAgreement/EC/H2020/826421info:eu-repo/grantAgreement/EC/H2020/820742cc by-nc-nd (c) Elsevier, 2019http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1642982026-05-27T06:46:51Z
dc.title.none.fl_str_mv Modulating grid cell scale and intrinsic frequencies via slow high-threshold conductances: A simplified model
title Modulating grid cell scale and intrinsic frequencies via slow high-threshold conductances: A simplified model
spellingShingle Modulating grid cell scale and intrinsic frequencies via slow high-threshold conductances: A simplified model
Santos-Pata, Diogo
Escorça cerebral
Neurones
Orientació animal
Cerebral cortex
Neurons
Animal orientation
title_short Modulating grid cell scale and intrinsic frequencies via slow high-threshold conductances: A simplified model
title_full Modulating grid cell scale and intrinsic frequencies via slow high-threshold conductances: A simplified model
title_fullStr Modulating grid cell scale and intrinsic frequencies via slow high-threshold conductances: A simplified model
title_full_unstemmed Modulating grid cell scale and intrinsic frequencies via slow high-threshold conductances: A simplified model
title_sort Modulating grid cell scale and intrinsic frequencies via slow high-threshold conductances: A simplified model
dc.creator.none.fl_str_mv Santos-Pata, Diogo
Zucca, Riccardo
López-Carral, Héctor
Verschure, Paul
author Santos-Pata, Diogo
author_facet Santos-Pata, Diogo
Zucca, Riccardo
López-Carral, Héctor
Verschure, Paul
author_role author
author2 Zucca, Riccardo
López-Carral, Héctor
Verschure, Paul
author2_role author
author
author
dc.subject.none.fl_str_mv Escorça cerebral
Neurones
Orientació animal
Cerebral cortex
Neurons
Animal orientation
topic Escorça cerebral
Neurones
Orientació animal
Cerebral cortex
Neurons
Animal orientation
description Grid cells in the medial entorhinal cortex (MEC) have known spatial periodic firing fields which provide a metric for the representation of self-location and path planning. The hexagonal tessellation pattern of grid cells scales up progressively along the MEC’s layer II dorsal-to-ventral axis. This scaling gradient has been hypothesized to originate either from inter-population synaptic dynamics as postulated by attractor networks, or from projected theta frequency waves to different axis levels, as in oscillatory models. Alternatively, cellular dynamics and specifically slow high-threshold conductances have been proposed to have an impact on the grid cell scale. To test the hypothesis that intrinsic hyperpolarization-activated cation currents account for both the scaled gradient and the oscillatory frequencies observed along the dorsal-to-ventral axis, we have modeled and analyzed data from a population of grid cells simulated with spiking neurons interacting through low-dimensional attractor dynamics. We observed that the intrinsic neuronal membrane properties of simulated cells were sufficient to induce an increase in grid scale and potentiate differences in the membrane potential oscillatory frequency. Overall, our results suggest that the after-spike dynamics of cation currents may play a major role in determining the grid cells’ scale and that oscillatory frequencies are a consequence of intrinsic cellular properties that are specific to different levels of the dorsal-to-ventral axis in the MEC layer II.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/164298
url https://hdl.handle.net/2445/164298
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1016/j.neunet.2019.06.011
Neural Networks, 2019, vol. 119, p. 66-73
https://doi.org/10.1016/j.neunet.2019.06.011
info:eu-repo/grantAgreement/EC/H2020/826421
info:eu-repo/grantAgreement/EC/H2020/820742
dc.rights.none.fl_str_mv cc by-nc-nd (c) Elsevier, 2019
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc-nd (c) Elsevier, 2019
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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