Dataset - Cr3+-doped gamma-and beta-Gallium Oxide Nanoprobes for Bioimaging: Synthesis, Persistent luminescence and Biocompatibility

File List: Fig 1b: Size histogram of undoped gamma-Ga2O3 particles Fig 1c: DLS curve in aqueous suspension of undoped gamma-Ga2O3 particles Fig 1d : XRD pattern of undoped gamma-Ga2O3 particles Fig 1f: TG curve of undoped gamma-Ga2O3 particles Fig 2e: Particle size distributions and normal fitted cu...

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Autores: Arroyo, Encarnación, Monje-Moreno, José Manuel, Torres-Herrero, Beatriz, Muñoz-Ruiz, Manuel Jesús, Fuente, Jesús M. de la, Becerro, Ana Isabel, Ocaña, Manuel
Formato: conjunto de datos
Fecha de publicación:2025
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/396295
Acesso em linha:http://hdl.handle.net/10261/396295
Access Level:acceso abierto
Palavra-chave:Gallium oxide
Persistent luminscence
Nanoparticles
Bioimaging
nanoparticles
id ES_efbd7a4cdd662729f097acd021a836d4
oai_identifier_str oai:digital.csic.es:10261/396295
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Dataset - Cr3+-doped gamma-and beta-Gallium Oxide Nanoprobes for Bioimaging: Synthesis, Persistent luminescence and Biocompatibility
title Dataset - Cr3+-doped gamma-and beta-Gallium Oxide Nanoprobes for Bioimaging: Synthesis, Persistent luminescence and Biocompatibility
spellingShingle Dataset - Cr3+-doped gamma-and beta-Gallium Oxide Nanoprobes for Bioimaging: Synthesis, Persistent luminescence and Biocompatibility
Arroyo, Encarnación
Gallium oxide
Persistent luminscence
Nanoparticles
Bioimaging
nanoparticles
title_short Dataset - Cr3+-doped gamma-and beta-Gallium Oxide Nanoprobes for Bioimaging: Synthesis, Persistent luminescence and Biocompatibility
title_full Dataset - Cr3+-doped gamma-and beta-Gallium Oxide Nanoprobes for Bioimaging: Synthesis, Persistent luminescence and Biocompatibility
title_fullStr Dataset - Cr3+-doped gamma-and beta-Gallium Oxide Nanoprobes for Bioimaging: Synthesis, Persistent luminescence and Biocompatibility
title_full_unstemmed Dataset - Cr3+-doped gamma-and beta-Gallium Oxide Nanoprobes for Bioimaging: Synthesis, Persistent luminescence and Biocompatibility
title_sort Dataset - Cr3+-doped gamma-and beta-Gallium Oxide Nanoprobes for Bioimaging: Synthesis, Persistent luminescence and Biocompatibility
dc.creator.none.fl_str_mv Arroyo, Encarnación
Monje-Moreno, José Manuel
Torres-Herrero, Beatriz
Muñoz-Ruiz, Manuel Jesús
Fuente, Jesús M. de la
Becerro, Ana Isabel
Ocaña, Manuel
author Arroyo, Encarnación
author_facet Arroyo, Encarnación
Monje-Moreno, José Manuel
Torres-Herrero, Beatriz
Muñoz-Ruiz, Manuel Jesús
Fuente, Jesús M. de la
Becerro, Ana Isabel
Ocaña, Manuel
author_role author
author2 Monje-Moreno, José Manuel
Torres-Herrero, Beatriz
Muñoz-Ruiz, Manuel Jesús
Fuente, Jesús M. de la
Becerro, Ana Isabel
Ocaña, Manuel
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (España)
Agencia Estatal de Investigación (España)
European Commission
European Science Foundation
Universidad de Zaragoza
Arroyo, Encarnación [0000-0002-5307-9803]
Monje-Moreno, José Manuel [0000-0003-2717-6412]
Torres-Herrero, Beatriz [0000-0003-4648-8972]
Muñoz-Ruiz, Manuel Jesús [0000-0002-1152-5449]
Fuente; Jesús M. de la [0000-0003-1081-8482]
Becerro, Ana Isabel [0000-0003-2243-5438]
Ocaña, Manuel [0000-0001-9989-606X]
Becerro, Ana I. [anieto@icmse.csic.es]
Arroyo, Encarnación
Monje-Moreno, José M.
Torres-Herrero, Beatriz
Muñoz, Manuel J
de la Fuente; Jesús M.
Becerro, Ana I.
Ocaña, Manuel
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Gallium oxide
Persistent luminscence
Nanoparticles
Bioimaging
nanoparticles
topic Gallium oxide
Persistent luminscence
Nanoparticles
Bioimaging
nanoparticles
description File List: Fig 1b: Size histogram of undoped gamma-Ga2O3 particles Fig 1c: DLS curve in aqueous suspension of undoped gamma-Ga2O3 particles Fig 1d : XRD pattern of undoped gamma-Ga2O3 particles Fig 1f: TG curve of undoped gamma-Ga2O3 particles Fig 2e: Particle size distributions and normal fitted curves of gamma-Ga2O3 particles doped with 0.1 %, 0.5 %, and 2.0 % Cr3+. Fig 2f: DLS curves of particles shown in (a) to (d) suspended in distilled water. Fig 3a: PLE spectrum of gamma-Ga2O3: 0.5 % Cr3+. Fig 3b: PL spectra of gamma-Ga2O3: x % Cr3+. Fig 3c: PersL decay curves of gamma-Ga2O3: x% Cr3+ after being illuminated with UV light (260 nm) for 5 min Fig 3d: PersL decay curves of gamma-Ga2O3: 2.0 % Cr3+ after being illuminated with UV light (260 nm) for 5 min recorded at two different emission wavelengths Fig 4b: FTIR spectra of the NPs@SiO2 and final NPs Fig 4c: Particle size distributions of the NPs@SiO2 and final NPs Fig 4d: DLS curves in aqueous suspension (pH 6) (d) of the NPs@SiO2 and final NPs Fig 4f: XRD pattern of the final NPs Fig 5a, 5b and 5c:Comparison of the photoluminescence properties of -Ga2O3 and gamma-Ga2O3 NPs. a) Absolute PL spectra, b) Normalized PL spectra, and c) PersL decay curves Fig 6a: PLE and PersL excitation spectra of beta-Ga2O3 NPs Fig 6b: PL and PersL emission spectra of beta-Ga2O3 NPs Fig 8a: DLS curves of beta-Ga2O3:2 % Cr3+ NPs dispersed in MES. Fig 8b: Zavg and PdI values as a function of time, obtained from DLS measurements on beta-Ga2O3:2 % Cr3+ NPs dispersed in MES. Fig 10: Cell viability assay of MIA PaCa-2 cell line exposed to different concentrations of beta-Ga2O3:2 % Cr3+ NPs for 24 h. Fig 11d: EDX spectrum of the region marked with a quadrangle in Fig 11b. Fig 12: Viability (a) and brood size (b) of N2 worms incubated at 20°C with different concentrations (mg·mL-1) of beta-Ga2O3:2 % Cr3+ NPs for 24h.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/dataset
http://purl.org/coar/resource_type/c_ddb1
format dataset
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/396295
url http://hdl.handle.net/10261/396295
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-122328OB-I00
Arroyo, Encarnación; Monje-Moreno, José M; Torres-Herrero, Beatriz; Muñoz, Manuel J,; Fuente, Jesús M, de la; Becerro, Ana; Ocaña, Manuel. Cr3+-doped gamma-and beta-Gallium Oxide Nanoprobes for Bioimaging: Synthesis, Persistent luminescence and Biocompatibility. https://doi.org/10.20350/digitalCSIC/17484. http://hdl.handle.net/10261/396295
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv DIGITAL.CSIC
publisher.none.fl_str_mv DIGITAL.CSIC
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869423891714146304
spelling Dataset - Cr3+-doped gamma-and beta-Gallium Oxide Nanoprobes for Bioimaging: Synthesis, Persistent luminescence and BiocompatibilityArroyo, EncarnaciónMonje-Moreno, José ManuelTorres-Herrero, BeatrizMuñoz-Ruiz, Manuel JesúsFuente, Jesús M. de laBecerro, Ana IsabelOcaña, ManuelGallium oxidePersistent luminscenceNanoparticlesBioimagingnanoparticlesFile List: Fig 1b: Size histogram of undoped gamma-Ga2O3 particles Fig 1c: DLS curve in aqueous suspension of undoped gamma-Ga2O3 particles Fig 1d : XRD pattern of undoped gamma-Ga2O3 particles Fig 1f: TG curve of undoped gamma-Ga2O3 particles Fig 2e: Particle size distributions and normal fitted curves of gamma-Ga2O3 particles doped with 0.1 %, 0.5 %, and 2.0 % Cr3+. Fig 2f: DLS curves of particles shown in (a) to (d) suspended in distilled water. Fig 3a: PLE spectrum of gamma-Ga2O3: 0.5 % Cr3+. Fig 3b: PL spectra of gamma-Ga2O3: x % Cr3+. Fig 3c: PersL decay curves of gamma-Ga2O3: x% Cr3+ after being illuminated with UV light (260 nm) for 5 min Fig 3d: PersL decay curves of gamma-Ga2O3: 2.0 % Cr3+ after being illuminated with UV light (260 nm) for 5 min recorded at two different emission wavelengths Fig 4b: FTIR spectra of the NPs@SiO2 and final NPs Fig 4c: Particle size distributions of the NPs@SiO2 and final NPs Fig 4d: DLS curves in aqueous suspension (pH 6) (d) of the NPs@SiO2 and final NPs Fig 4f: XRD pattern of the final NPs Fig 5a, 5b and 5c:Comparison of the photoluminescence properties of -Ga2O3 and gamma-Ga2O3 NPs. a) Absolute PL spectra, b) Normalized PL spectra, and c) PersL decay curves Fig 6a: PLE and PersL excitation spectra of beta-Ga2O3 NPs Fig 6b: PL and PersL emission spectra of beta-Ga2O3 NPs Fig 8a: DLS curves of beta-Ga2O3:2 % Cr3+ NPs dispersed in MES. Fig 8b: Zavg and PdI values as a function of time, obtained from DLS measurements on beta-Ga2O3:2 % Cr3+ NPs dispersed in MES. Fig 10: Cell viability assay of MIA PaCa-2 cell line exposed to different concentrations of beta-Ga2O3:2 % Cr3+ NPs for 24 h. Fig 11d: EDX spectrum of the region marked with a quadrangle in Fig 11b. Fig 12: Viability (a) and brood size (b) of N2 worms incubated at 20°C with different concentrations (mg·mL-1) of beta-Ga2O3:2 % Cr3+ NPs for 24h.Persistent luminescent nanophosphors that emit in the near infrared region are promising nanoprobes for in-vivo bioimaging. Although Cr3+-doped zinc gallate nanoparticles have been widely studied as in-vivo bioimaging nanoprobes due to their NIR persistent luminescence emission at 695 nm, the simpler Cr3+-doped gallium oxide system has been less explored despite its deeper NIR emission (760 nm), which favours tissue penetration. This is likely due the lack of synthesis methods that render Ga2O3-based nanoparticles suitable for in-vivo applications. In this paper, we report a novel method for the synthesis of uniform and hydrophilic -Ga2O3:Cr3+ nanoparticles, whose photoluminescence and persistent luminescence were optimized by adjusting their Cr3+ content. Such properties were further greatly improved through an annealing process at high temperature, which resulted in the transformation of its crystal structure into the -phase. The obtained -Ga2O3:Cr3+ nanoparticles were colloidally stable in a physiological pH simulator medium and were nontoxic for cells. Finally, we also studied, for the first time in literature, the in-vivo biocompatibility of such nanoparticles using a C. elegans animal model, finding that their morbidity and reproductive toxicity were negligible. In summary, the reported nanoparticles are excellent candidates for their use as a NIR persistent luminescence probes for in-vivo bioimaging.This publication is part of the I + D + I grant PID2021-122328OB-I00 funded by MCIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe”. E.A. acknowledges Grant FPU19/00527 funded by MCIN/AEI/10.13039/501100011033 and by “ESF Investing in your future”. B.T.H. acknowledges Grant FPU19/01311 funded by MCIN/AEI/10.13039/501100011033 and by “ESF Investing in your future”. Authors would like to acknowledge the use of Servicios Científico-Técnicos del CIBA (IACS-Universidad de Zaragoza), specifically to the Preclinical Imaging and phenotyping Unit.File List: Fig 1b: Size histogram of undoped gamma-Ga2O3 particles Fig 1c: DLS curve in aqueous suspension of undoped gamma-Ga2O3 particles Fig 1d : XRD pattern of undoped gamma-Ga2O3 particles Fig 1f: TG curve of undoped gamma-Ga2O3 particles Fig 2e: Particle size distributions and normal fitted curves of gamma-Ga2O3 particles doped with 0.1 %, 0.5 %, and 2.0 % Cr3+. Fig 2f: DLS curves of particles shown in (a) to (d) suspended in distilled water. Fig 3a: PLE spectrum of gamma-Ga2O3: 0.5 % Cr3+. Fig 3b: PL spectra of gamma-Ga2O3: x % Cr3+. Fig 3c: PersL decay curves of gamma-Ga2O3: x% Cr3+ after being illuminated with UV light (260 nm) for 5 min Fig 3d: PersL decay curves of gamma-Ga2O3: 2.0 % Cr3+ after being illuminated with UV light (260 nm) for 5 min recorded at two different emission wavelengths Fig 4b: FTIR spectra of the NPs@SiO2 and final NPs Fig 4c: Particle size distributions of the NPs@SiO2 and final NPs Fig 4d: DLS curves in aqueous suspension (pH 6) (d) of the NPs@SiO2 and final NPs Fig 4f: XRD pattern of the final NPs Fig 5a, 5b and 5c:Comparison of the photoluminescence properties of -Ga2O3 and gamma-Ga2O3 NPs. a) Absolute PL spectra, b) Normalized PL spectra, and c) PersL decay curves Fig 6a: PLE and PersL excitation spectra of beta-Ga2O3 NPs Fig 6b: PL and PersL emission spectra of beta-Ga2O3 NPs Fig 8a: DLS curves of beta-Ga2O3:2 % Cr3+ NPs dispersed in MES. Fig 8b: Zavg and PdI values as a function of time, obtained from DLS measurements on beta-Ga2O3:2 % Cr3+ NPs dispersed in MES. Fig 10: Cell viability assay of MIA PaCa-2 cell line exposed to different concentrations of beta-Ga2O3:2 % Cr3+ NPs for 24 h. Fig 11d: EDX spectrum of the region marked with a quadrangle in Fig 11b. Fig 12: Viability (a) and brood size (b) of N2 worms incubated at 20°C with different concentrations (mg·mL-1) of beta-Ga2O3:2 % Cr3+ NPs for 24h.Peer reviewedDIGITAL.CSICMinisterio de Ciencia e Innovación (España)Agencia Estatal de Investigación (España)European CommissionEuropean Science FoundationUniversidad de ZaragozaArroyo, Encarnación [0000-0002-5307-9803]Monje-Moreno, José Manuel [0000-0003-2717-6412]Torres-Herrero, Beatriz [0000-0003-4648-8972]Muñoz-Ruiz, Manuel Jesús [0000-0002-1152-5449]Fuente; Jesús M. de la [0000-0003-1081-8482]Becerro, Ana Isabel [0000-0003-2243-5438]Ocaña, Manuel [0000-0001-9989-606X]Becerro, Ana I. [anieto@icmse.csic.es]Arroyo, EncarnaciónMonje-Moreno, José M.Torres-Herrero, BeatrizMuñoz, Manuel Jde la Fuente; Jesús M.Becerro, Ana I.Ocaña, ManuelConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252025info:eu-repo/semantics/datasethttp://purl.org/coar/resource_type/c_ddb1application/pdfhttp://hdl.handle.net/10261/396295reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-122328OB-I00Arroyo, Encarnación; Monje-Moreno, José M; Torres-Herrero, Beatriz; Muñoz, Manuel J,; Fuente, Jesús M, de la; Becerro, Ana; Ocaña, Manuel. Cr3+-doped gamma-and beta-Gallium Oxide Nanoprobes for Bioimaging: Synthesis, Persistent luminescence and Biocompatibility. https://doi.org/10.20350/digitalCSIC/17484. http://hdl.handle.net/10261/396295Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3962952026-05-22T06:33:51Z
score 15,812429

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