Complications of Haploidentical Hematopoietic Cell Transplantation with Post-Transplant Cyclophosphamide—A Prospective Study on Behalf of the EBMT Transplant Complications Working Party

Background: Haploidentical hematopoietic cell transplantations (haplo-HCTs) with post-transplant cyclophosphamide (PT-Cy) are standard practice, but complications causing morbidity and mortality are not well described. Methods: The aim of this prospective non-interventional multicenter study was to...

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Autores: Tomaszewska, Agnieszka, Basak, Grzegorz W., Peczynski, Christophe, Polge, Emmanuelle, Ambron, Pascale, Boreland, William, Sica, Simona, Arat, Mutlu, Passweg, Jakob, López Lorenzo, José Luis, Salmenniemi, Urpu, Jindra, Pavel, Kulagin, Alexander, Martino Bufarull, Rodrigo, Eder, Matthias, Bekadja, Mohamed Amine, Mussetti, Alberto, Graham, Charlotte E., Schoemans, Hélène, Penack, Olaf, Moiseev, Ivan, Perić, Zinaida
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:dnet:recercat____::470e79a6da45478a2d5ba33fe183fe41
Acceso en línea:https://hdl.handle.net/2445/228756
Access Level:acceso abierto
Palabra clave:Trasplantament d'òrgans
Hemofília
Hematopoesi
Transplantation of organs
Hemophilia
Hematopoiesis
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spelling Complications of Haploidentical Hematopoietic Cell Transplantation with Post-Transplant Cyclophosphamide—A Prospective Study on Behalf of the EBMT Transplant Complications Working PartyTomaszewska, AgnieszkaBasak, Grzegorz W.Peczynski, ChristophePolge, EmmanuelleAmbron, PascaleBoreland, WilliamSica, SimonaArat, MutluPassweg, JakobLópez Lorenzo, José LuisSalmenniemi, UrpuJindra, PavelKulagin, AlexanderMartino Bufarull, RodrigoEder, MatthiasBekadja, Mohamed AmineMussetti, AlbertoGraham, Charlotte E.Schoemans, HélènePenack, OlafMoiseev, IvanPerić, ZinaidaTrasplantament d'òrgansHemofíliaHematopoesiTransplantation of organsHemophiliaHematopoiesisBackground: Haploidentical hematopoietic cell transplantations (haplo-HCTs) with post-transplant cyclophosphamide (PT-Cy) are standard practice, but complications causing morbidity and mortality are not well described. Methods: The aim of this prospective non-interventional multicenter study was to document frequency of potential non-infectious and infection-related complications and main transplant outcomes after the first unmanipulated haplo-HCT with PT-Cy between 2017 and 2019 in 129 adult patients with hematological malignancies. The median follow-up was 37.3 months [95% CI: 34.3-39.7]. Results: The cumulative incidence (CI) of acute graft versus host disease (aGvHD) at day +100 was 22.4% grade II-IV [95% CI: 15.5-30.1] and 8.8% grade III-IV [95% CI: 4.6-14.6], respectively. The cumulative incidence of chronic GvHD (cGvHD) at 24 months was 25.8% [95% CI: 18.5-33.6]; extensive cGvHD was 10.9% [95% CI: 6.3-17.1], respectively. The most frequent non-infectious complications for the whole study population were mucositis-37.5% (n = 48); renal insufficiency-18% (n = 23); and cardiovascular complications-10.9% (n = 14). The following infection-related complications were diagnosed: bacterial in 84 (65.1%), viral in 66 (51.6%), and fungal in 24 (18.6%) recipients. Two-year OS was 58.1% [95% CI: 50.2-67.3]; NRM-27.1% [95% CI: 19.7-35]; PFS-50.4% [95% CI: 42.5-59.8]; and GRFS-38.8% [95% CI: 31.2-48.1]. About 50% of all deaths were directly caused by infection or infection-related conditions. Conclusions: Disease remission status at transplant significantly affected PFS, chronic GvHD, and GRFS. Although clinical applications of haplo-HCT with PTCy are widespread, the study confirms the need to reduce infection-related mortality after this type of GvHD prophylaxis.MDPI AG2026202620252026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion17 p.application/pdfhttps://hdl.handle.net/2445/228756Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/cancers17244029Cancers, 2025, vol. 17, num. 24, 4029https://doi.org/10.3390/cancers17244029cc-by (c) Tomaszewska, Agnieszka et al., 2025https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:dnet:recercat____::470e79a6da45478a2d5ba33fe183fe412026-05-29T05:05:01Z
dc.title.none.fl_str_mv Complications of Haploidentical Hematopoietic Cell Transplantation with Post-Transplant Cyclophosphamide—A Prospective Study on Behalf of the EBMT Transplant Complications Working Party
title Complications of Haploidentical Hematopoietic Cell Transplantation with Post-Transplant Cyclophosphamide—A Prospective Study on Behalf of the EBMT Transplant Complications Working Party
spellingShingle Complications of Haploidentical Hematopoietic Cell Transplantation with Post-Transplant Cyclophosphamide—A Prospective Study on Behalf of the EBMT Transplant Complications Working Party
Tomaszewska, Agnieszka
Trasplantament d'òrgans
Hemofília
Hematopoesi
Transplantation of organs
Hemophilia
Hematopoiesis
title_short Complications of Haploidentical Hematopoietic Cell Transplantation with Post-Transplant Cyclophosphamide—A Prospective Study on Behalf of the EBMT Transplant Complications Working Party
title_full Complications of Haploidentical Hematopoietic Cell Transplantation with Post-Transplant Cyclophosphamide—A Prospective Study on Behalf of the EBMT Transplant Complications Working Party
title_fullStr Complications of Haploidentical Hematopoietic Cell Transplantation with Post-Transplant Cyclophosphamide—A Prospective Study on Behalf of the EBMT Transplant Complications Working Party
title_full_unstemmed Complications of Haploidentical Hematopoietic Cell Transplantation with Post-Transplant Cyclophosphamide—A Prospective Study on Behalf of the EBMT Transplant Complications Working Party
title_sort Complications of Haploidentical Hematopoietic Cell Transplantation with Post-Transplant Cyclophosphamide—A Prospective Study on Behalf of the EBMT Transplant Complications Working Party
dc.creator.none.fl_str_mv Tomaszewska, Agnieszka
Basak, Grzegorz W.
Peczynski, Christophe
Polge, Emmanuelle
Ambron, Pascale
Boreland, William
Sica, Simona
Arat, Mutlu
Passweg, Jakob
López Lorenzo, José Luis
Salmenniemi, Urpu
Jindra, Pavel
Kulagin, Alexander
Martino Bufarull, Rodrigo
Eder, Matthias
Bekadja, Mohamed Amine
Mussetti, Alberto
Graham, Charlotte E.
Schoemans, Hélène
Penack, Olaf
Moiseev, Ivan
Perić, Zinaida
author Tomaszewska, Agnieszka
author_facet Tomaszewska, Agnieszka
Basak, Grzegorz W.
Peczynski, Christophe
Polge, Emmanuelle
Ambron, Pascale
Boreland, William
Sica, Simona
Arat, Mutlu
Passweg, Jakob
López Lorenzo, José Luis
Salmenniemi, Urpu
Jindra, Pavel
Kulagin, Alexander
Martino Bufarull, Rodrigo
Eder, Matthias
Bekadja, Mohamed Amine
Mussetti, Alberto
Graham, Charlotte E.
Schoemans, Hélène
Penack, Olaf
Moiseev, Ivan
Perić, Zinaida
author_role author
author2 Basak, Grzegorz W.
Peczynski, Christophe
Polge, Emmanuelle
Ambron, Pascale
Boreland, William
Sica, Simona
Arat, Mutlu
Passweg, Jakob
López Lorenzo, José Luis
Salmenniemi, Urpu
Jindra, Pavel
Kulagin, Alexander
Martino Bufarull, Rodrigo
Eder, Matthias
Bekadja, Mohamed Amine
Mussetti, Alberto
Graham, Charlotte E.
Schoemans, Hélène
Penack, Olaf
Moiseev, Ivan
Perić, Zinaida
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Trasplantament d'òrgans
Hemofília
Hematopoesi
Transplantation of organs
Hemophilia
Hematopoiesis
topic Trasplantament d'òrgans
Hemofília
Hematopoesi
Transplantation of organs
Hemophilia
Hematopoiesis
description Background: Haploidentical hematopoietic cell transplantations (haplo-HCTs) with post-transplant cyclophosphamide (PT-Cy) are standard practice, but complications causing morbidity and mortality are not well described. Methods: The aim of this prospective non-interventional multicenter study was to document frequency of potential non-infectious and infection-related complications and main transplant outcomes after the first unmanipulated haplo-HCT with PT-Cy between 2017 and 2019 in 129 adult patients with hematological malignancies. The median follow-up was 37.3 months [95% CI: 34.3-39.7]. Results: The cumulative incidence (CI) of acute graft versus host disease (aGvHD) at day +100 was 22.4% grade II-IV [95% CI: 15.5-30.1] and 8.8% grade III-IV [95% CI: 4.6-14.6], respectively. The cumulative incidence of chronic GvHD (cGvHD) at 24 months was 25.8% [95% CI: 18.5-33.6]; extensive cGvHD was 10.9% [95% CI: 6.3-17.1], respectively. The most frequent non-infectious complications for the whole study population were mucositis-37.5% (n = 48); renal insufficiency-18% (n = 23); and cardiovascular complications-10.9% (n = 14). The following infection-related complications were diagnosed: bacterial in 84 (65.1%), viral in 66 (51.6%), and fungal in 24 (18.6%) recipients. Two-year OS was 58.1% [95% CI: 50.2-67.3]; NRM-27.1% [95% CI: 19.7-35]; PFS-50.4% [95% CI: 42.5-59.8]; and GRFS-38.8% [95% CI: 31.2-48.1]. About 50% of all deaths were directly caused by infection or infection-related conditions. Conclusions: Disease remission status at transplant significantly affected PFS, chronic GvHD, and GRFS. Although clinical applications of haplo-HCT with PTCy are widespread, the study confirms the need to reduce infection-related mortality after this type of GvHD prophylaxis.
publishDate 2025
dc.date.none.fl_str_mv 2025
2026
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/228756
url https://hdl.handle.net/2445/228756
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/cancers17244029
Cancers, 2025, vol. 17, num. 24, 4029
https://doi.org/10.3390/cancers17244029
dc.rights.none.fl_str_mv cc-by (c) Tomaszewska, Agnieszka et al., 2025
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Tomaszewska, Agnieszka et al., 2025
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 17 p.
application/pdf
dc.publisher.none.fl_str_mv MDPI AG
publisher.none.fl_str_mv MDPI AG
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869423891058786304
score 15,812429

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