Antibacterial and cytocompatible silver coating for titanium boston keratoprosthesis

The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This work was supported by the Spanish State Research Agency through project PID 2021-125150OB-I00 and project PDC 2022-133628-C21. The authors also thank the Generalitat de Ca...

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Autores: González Gómez, Silvia, Ginebra, Maria-Pau, Gil, FJ, Barraquer, Rafael I, Manero, José María
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:20.500.12328/4805
Acceso en línea:http://hdl.handle.net/20.500.12328/4805
https://dx.doi.org/10.3389/fbioe.2024.1421706
Access Level:acceso abierto
Palabra clave:Queratopròtesi de Boston (BKPro)
Ceguesa corneal
Titani (Ti)
Infecció
Antibacterià
Propietats
Electrodeposició
Citotoxicitat
Deposició de plata
Queratoprótesis de Boston (BKPro)
Ceguera corneal
Titanio (Ti)
Infección
Propiedades antibacterianas
Electrodeposición
Citotoxicidad
Deposición de plata
Boston keratoprosthesis (BKPro)
Corneal blindness
Titanium (Ti)
Infection
Antibacterial properties
Electrodeposition
Cytotoxicicity
Silver deposition
616.3
id ES_efb4f3acf205dceefba74d5245ff89a1
oai_identifier_str oai:recercat.cat:20.500.12328/4805
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Antibacterial and cytocompatible silver coating for titanium boston keratoprosthesis
title Antibacterial and cytocompatible silver coating for titanium boston keratoprosthesis
spellingShingle Antibacterial and cytocompatible silver coating for titanium boston keratoprosthesis
González Gómez, Silvia
Queratopròtesi de Boston (BKPro)
Ceguesa corneal
Titani (Ti)
Infecció
Antibacterià
Propietats
Electrodeposició
Citotoxicitat
Deposició de plata
Queratoprótesis de Boston (BKPro)
Ceguera corneal
Titanio (Ti)
Infección
Propiedades antibacterianas
Electrodeposición
Citotoxicidad
Deposición de plata
Boston keratoprosthesis (BKPro)
Corneal blindness
Titanium (Ti)
Infection
Antibacterial properties
Electrodeposition
Cytotoxicicity
Silver deposition
616.3
title_short Antibacterial and cytocompatible silver coating for titanium boston keratoprosthesis
title_full Antibacterial and cytocompatible silver coating for titanium boston keratoprosthesis
title_fullStr Antibacterial and cytocompatible silver coating for titanium boston keratoprosthesis
title_full_unstemmed Antibacterial and cytocompatible silver coating for titanium boston keratoprosthesis
title_sort Antibacterial and cytocompatible silver coating for titanium boston keratoprosthesis
dc.creator.none.fl_str_mv González Gómez, Silvia
Ginebra, Maria-Pau
Gil, FJ
Barraquer, Rafael I
Manero, José María
author González Gómez, Silvia
author_facet González Gómez, Silvia
Ginebra, Maria-Pau
Gil, FJ
Barraquer, Rafael I
Manero, José María
author_role author
author2 Ginebra, Maria-Pau
Gil, FJ
Barraquer, Rafael I
Manero, José María
author2_role author
author
author
author
dc.subject.none.fl_str_mv Queratopròtesi de Boston (BKPro)
Ceguesa corneal
Titani (Ti)
Infecció
Antibacterià
Propietats
Electrodeposició
Citotoxicitat
Deposició de plata
Queratoprótesis de Boston (BKPro)
Ceguera corneal
Titanio (Ti)
Infección
Propiedades antibacterianas
Electrodeposición
Citotoxicidad
Deposición de plata
Boston keratoprosthesis (BKPro)
Corneal blindness
Titanium (Ti)
Infection
Antibacterial properties
Electrodeposition
Cytotoxicicity
Silver deposition
616.3
topic Queratopròtesi de Boston (BKPro)
Ceguesa corneal
Titani (Ti)
Infecció
Antibacterià
Propietats
Electrodeposició
Citotoxicitat
Deposició de plata
Queratoprótesis de Boston (BKPro)
Ceguera corneal
Titanio (Ti)
Infección
Propiedades antibacterianas
Electrodeposición
Citotoxicidad
Deposición de plata
Boston keratoprosthesis (BKPro)
Corneal blindness
Titanium (Ti)
Infection
Antibacterial properties
Electrodeposition
Cytotoxicicity
Silver deposition
616.3
description The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This work was supported by the Spanish State Research Agency through project PID 2021-125150OB-I00 and project PDC 2022-133628-C21. The authors also thank the Generalitat de Catalunya for funding through project 2019PROD000053 (co-funded by the European Regional Development Fund), and the FI-AGAUR (grant 2022 FIB00210) of SG. This work is part of Maria de Maeztu Units of Excellence Programme CEX2023-001300-M/ funded by MCIN/AEI/10.13039/501100011033.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12328/4805
https://dx.doi.org/10.3389/fbioe.2024.1421706
url http://hdl.handle.net/20.500.12328/4805
https://dx.doi.org/10.3389/fbioe.2024.1421706
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Frontiers in Bioengineering and Biotechnology
12
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 16
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869423888769744896
spelling Antibacterial and cytocompatible silver coating for titanium boston keratoprosthesisGonzález Gómez, SilviaGinebra, Maria-PauGil, FJBarraquer, Rafael IManero, José MaríaQueratopròtesi de Boston (BKPro)Ceguesa cornealTitani (Ti)InfeccióAntibacteriàPropietatsElectrodeposicióCitotoxicitatDeposició de plataQueratoprótesis de Boston (BKPro)Ceguera cornealTitanio (Ti)InfecciónPropiedades antibacterianasElectrodeposiciónCitotoxicidadDeposición de plataBoston keratoprosthesis (BKPro)Corneal blindnessTitanium (Ti)InfectionAntibacterial propertiesElectrodepositionCytotoxicicitySilver deposition616.3The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This work was supported by the Spanish State Research Agency through project PID 2021-125150OB-I00 and project PDC 2022-133628-C21. The authors also thank the Generalitat de Catalunya for funding through project 2019PROD000053 (co-funded by the European Regional Development Fund), and the FI-AGAUR (grant 2022 FIB00210) of SG. This work is part of Maria de Maeztu Units of Excellence Programme CEX2023-001300-M/ funded by MCIN/AEI/10.13039/501100011033.The Boston Keratoprosthesis (BKPro) serves as a medical solution for restoring vision in complex cases of corneal blindness. Comprising a front plate made of polymethylmethacrylate (PMMA) and a back plate of titanium (Ti), this device utilizes the beneficial biomaterial properties of Ti. While BKPro demonstrates promising retention rates, infection emerges as a significant concern that impacts its long-term efficacy. However, limited research exists on enhancement of BKPros through intrinsic infection-preventing mechanisms. In this regard, metal ions, especially the well-known Ag+ ions, are a promising alternative to obtain implants with innate antibacterial properties. However, little information is available about the effects of Ag in corneal tissue, especially within human corneal keratocytes (HCKs). In this work, an electrodeposition treatment using a constant pulse is proposed to attach Ag complexes onto rough Ti surfaces, thus providing antibacterial properties without inducing cytotoxicity. Complete physicochemical characterization and ion release studies were carried out with both control and Ag-treated samples. The possible cytotoxic effects in the short and long term were evaluated in vitro with HCKs. Moreover, the antibacterial properties of the silver-treated surfaces were tested against the gram-negative bacterial strain Pseudomonas aeruginosa and the gram-positive strain Staphylococcus epidermidis, that are common contributors to infections in BKPros. Physicochemical characterization confirmed the presence of silver, predominantly in oxide form, with low release of Ag+ ions. Ag-treated surfaces demonstrated no cytotoxicity and promoted long-term proliferation of HCKs. Furthermore, the silver-treated surfaces exhibited a potent antibacterial effect, causing a reduction in bacterial adhesion and evident damage to the bacterial cell walls of P. aeruginosa and S. epidermidis. The low release of Ag+ ions suggested reactive oxygen species (ROS)-mediated oxidative stress imbalance as the bactericidal mechanism of the silver deposits. In conclusion, the proposed electrodeposition technique confers antibacterial protection to the Ti backplate of BKPro, mitigating implant-threatening infections while ensuring non-cytotoxicity within the corneal tissue.info:eu-repo/semantics/publishedVersionFrontiers Media2024info:eu-repo/semantics/article16http://hdl.handle.net/20.500.12328/4805https://dx.doi.org/10.3389/fbioe.2024.1421706reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésFrontiers in Bioengineering and Biotechnology12© 2024 Gómez, Ginebra, Gil, Barraquer and Manero. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:20.500.12328/48052026-05-29T05:05:01Z
score 15.81155

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