An experimental fatigue study of a porous scaffold for the regeneration of articular cartilage

The aim of this experimental study is to predict the long-term mechanical behavior of a porous scaffold implanted in a cartilage defect for tissue engineering purpose. Fatigue studies were performed by up to 100,000 unconfined compression cycles in a polycaprolactone (PCL) scaffold with highly inter...

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Autores: Vikingsson, Line Karina Alva, Gómez-Tejedor, José-Antonio|||0000-0001-6854-0829, Gallego-Ferrer, Gloria|||0000-0002-2428-0903, Gómez Ribelles, José Luís|||0000-0001-9099-0885
Tipo de documento: artigo
Data de publicação:2015
País:España
Recursos:Universitat Politècnica de València (UPV)
Repositório:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Idioma:espanhol
OAI Identifier:oai:riunet.upv.es:10251/64126
Acesso em linha:https://riunet.upv.es/handle/10251/64126
Access Level:Acceso aberto
Palavra-chave:Tissue engineering
Scaffolds
Mechanical properties of biomaterials
Fatigue prediction
Cartilage regeneration
Electron Microscopy Service of the UPV
MAQUINAS Y MOTORES TERMICOS
FISICA APLICADA
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spelling An experimental fatigue study of a porous scaffold for the regeneration of articular cartilageVikingsson, Line Karina AlvaGómez-Tejedor, José-Antonio|||0000-0001-6854-0829Gallego-Ferrer, Gloria|||0000-0002-2428-0903Gómez Ribelles, José Luís|||0000-0001-9099-0885Tissue engineeringScaffoldsMechanical properties of biomaterialsFatigue predictionCartilage regenerationElectron Microscopy Service of the UPVMAQUINAS Y MOTORES TERMICOSFISICA APLICADAThe aim of this experimental study is to predict the long-term mechanical behavior of a porous scaffold implanted in a cartilage defect for tissue engineering purpose. Fatigue studies were performed by up to 100,000 unconfined compression cycles in a polycaprolactone (PCL) scaffold with highly interconnected pores architecture. The scaffold compliance, stress strain response and hysteresis energy have been measured after different number of fatigue cycles, while the morphology has been observed by scanning electron microscopy at the same fatigue times. To simulate the growing tissue in the scaffold/tissue construct, the scaffold was filled with an aqueous solution of polyvinyl alcohol (PVA) and subjected to repeating cycles of freezing and thawing that increase the hydrogel stiffness. Fatigue studies show that the mechanical loading provokes failure of the dry scaffold at a smaller number of deformation cycles than when it is immersed in water, and also that 100,000 compressive dynamic cycles do not affect the scaffold/gel construct. This shows the stability of the scaffold implanted in a chondral defect and gives a realistic simulation of the mechanical performance from implantation of the empty scaffold to regeneration of the new tissue inside the scaffold's pores.This work was funded by the Spanish Ministry of Economy and Competitiveness (MINECO) through the project MAT2013-46467-C4-1-R (including the FEDER financial support). CIBER-BBN is an initiative funded by the VI National R&D&i Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program, CIBER Actions and financed by the Instituto de Salud Carlos III with assistance from the European Regional Development Fund. The authors acknowledge the assistance and advice of Electron Microscopy Service of the UPVElsevierDepartamento de Física AplicadaEscuela Técnica Superior de Ingeniería Aeroespacial y Diseño IndustrialDepartamento de Termodinámica AplicadaEscuela Técnica Superior de Ingeniería Geodésica, Cartográfica y TopográficaCentro de Biomateriales e Ingeniería TisularEscuela Técnica Superior de Ingeniería IndustrialMinisterio de Economía y CompetitividadInstituto de Salud Carlos IIIEuropean Regional Development FundMinisterio de Ciencia e InnovaciónRepositorio Institucional de la Universitat Politècnica de València Riunet20152015-05-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://riunet.upv.es/handle/10251/64126reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)EspañolspaMinisterio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 MAT2013-46467-C4-1-R ESTIMULACION MECANICA LOCAL DE CELULAS MESENQUIMALES DE CARA A SU DIFERENCIACION OSTEOGENICA Y CONDROGENICA EN MEDICINA REGENERATIVAopen accesshttp://purl.org/coar/access_right/c_abf2Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/641262026-06-13T07:49:27Z
dc.title.none.fl_str_mv An experimental fatigue study of a porous scaffold for the regeneration of articular cartilage
title An experimental fatigue study of a porous scaffold for the regeneration of articular cartilage
spellingShingle An experimental fatigue study of a porous scaffold for the regeneration of articular cartilage
Vikingsson, Line Karina Alva
Tissue engineering
Scaffolds
Mechanical properties of biomaterials
Fatigue prediction
Cartilage regeneration
Electron Microscopy Service of the UPV
MAQUINAS Y MOTORES TERMICOS
FISICA APLICADA
title_short An experimental fatigue study of a porous scaffold for the regeneration of articular cartilage
title_full An experimental fatigue study of a porous scaffold for the regeneration of articular cartilage
title_fullStr An experimental fatigue study of a porous scaffold for the regeneration of articular cartilage
title_full_unstemmed An experimental fatigue study of a porous scaffold for the regeneration of articular cartilage
title_sort An experimental fatigue study of a porous scaffold for the regeneration of articular cartilage
dc.creator.none.fl_str_mv Vikingsson, Line Karina Alva
Gómez-Tejedor, José-Antonio|||0000-0001-6854-0829
Gallego-Ferrer, Gloria|||0000-0002-2428-0903
Gómez Ribelles, José Luís|||0000-0001-9099-0885
author Vikingsson, Line Karina Alva
author_facet Vikingsson, Line Karina Alva
Gómez-Tejedor, José-Antonio|||0000-0001-6854-0829
Gallego-Ferrer, Gloria|||0000-0002-2428-0903
Gómez Ribelles, José Luís|||0000-0001-9099-0885
author_role author
author2 Gómez-Tejedor, José-Antonio|||0000-0001-6854-0829
Gallego-Ferrer, Gloria|||0000-0002-2428-0903
Gómez Ribelles, José Luís|||0000-0001-9099-0885
author2_role author
author
author
dc.contributor.none.fl_str_mv Departamento de Física Aplicada
Escuela Técnica Superior de Ingeniería Aeroespacial y Diseño Industrial
Departamento de Termodinámica Aplicada
Escuela Técnica Superior de Ingeniería Geodésica, Cartográfica y Topográfica
Centro de Biomateriales e Ingeniería Tisular
Escuela Técnica Superior de Ingeniería Industrial
Ministerio de Economía y Competitividad
Instituto de Salud Carlos III
European Regional Development Fund
Ministerio de Ciencia e Innovación
Repositorio Institucional de la Universitat Politècnica de València Riunet
dc.subject.none.fl_str_mv Tissue engineering
Scaffolds
Mechanical properties of biomaterials
Fatigue prediction
Cartilage regeneration
Electron Microscopy Service of the UPV
MAQUINAS Y MOTORES TERMICOS
FISICA APLICADA
topic Tissue engineering
Scaffolds
Mechanical properties of biomaterials
Fatigue prediction
Cartilage regeneration
Electron Microscopy Service of the UPV
MAQUINAS Y MOTORES TERMICOS
FISICA APLICADA
description The aim of this experimental study is to predict the long-term mechanical behavior of a porous scaffold implanted in a cartilage defect for tissue engineering purpose. Fatigue studies were performed by up to 100,000 unconfined compression cycles in a polycaprolactone (PCL) scaffold with highly interconnected pores architecture. The scaffold compliance, stress strain response and hysteresis energy have been measured after different number of fatigue cycles, while the morphology has been observed by scanning electron microscopy at the same fatigue times. To simulate the growing tissue in the scaffold/tissue construct, the scaffold was filled with an aqueous solution of polyvinyl alcohol (PVA) and subjected to repeating cycles of freezing and thawing that increase the hydrogel stiffness. Fatigue studies show that the mechanical loading provokes failure of the dry scaffold at a smaller number of deformation cycles than when it is immersed in water, and also that 100,000 compressive dynamic cycles do not affect the scaffold/gel construct. This shows the stability of the scaffold implanted in a chondral defect and gives a realistic simulation of the mechanical performance from implantation of the empty scaffold to regeneration of the new tissue inside the scaffold's pores.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-05-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://riunet.upv.es/handle/10251/64126
url https://riunet.upv.es/handle/10251/64126
dc.language.none.fl_str_mv Español
spa
language_invalid_str_mv Español
language spa
dc.relation.none.fl_str_mv Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 MAT2013-46467-C4-1-R ESTIMULACION MECANICA LOCAL DE CELULAS MESENQUIMALES DE CARA A SU DIFERENCIACION OSTEOGENICA Y CONDROGENICA EN MEDICINA REGENERATIVA
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento - No comercial - Sin obra derivada (by-nc-nd)
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento - No comercial - Sin obra derivada (by-nc-nd)
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname:Universitat Politècnica de València (UPV)
instname_str Universitat Politècnica de València (UPV)
reponame_str RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
collection RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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