Hierarchical Cluster Analysis Based on Clinical and Neuropsychological Symptoms Reveals Distinct Subgroups in Fibromyalgia: A Population-Based Cohort Study

Cluster analysis; Fibromyalgia; Neuropsychological symptoms

Detalles Bibliográficos
Autores: Maurel Ibáñez, Sara Nieves, Giménez-Llort, Lydia, Alegre, Jose, Castro-Marrero, Jesus
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:11351/10577
Acceso en línea:https://hdl.handle.net/11351/10577
http://hdl.handle.net/11351/10577
Access Level:acceso abierto
Palabra clave:Dolor crònic
Fatiga
Fibromiàlgia - Tractament
DISEASES::Musculoskeletal Diseases::Muscular Diseases::Fibromyalgia
Other subheadings::Other subheadings::/therapy
DISEASES::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Neurologic Manifestations::Pain::Chronic Pain
DISEASES::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Fatigue
ENFERMEDADES::enfermedades musculoesqueléticas::enfermedades musculares::fibromialgia
Otros calificadores::Otros calificadores::/terapia
ENFERMEDADES::afecciones patológicas, signos y síntomas::signos y síntomas::manifestaciones neurológicas::dolor::dolor crónico
ENFERMEDADES::afecciones patológicas, signos y síntomas::signos y síntomas::fatiga
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oai_identifier_str oai:recercat.cat:11351/10577
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Hierarchical Cluster Analysis Based on Clinical and Neuropsychological Symptoms Reveals Distinct Subgroups in Fibromyalgia: A Population-Based Cohort Study
title Hierarchical Cluster Analysis Based on Clinical and Neuropsychological Symptoms Reveals Distinct Subgroups in Fibromyalgia: A Population-Based Cohort Study
spellingShingle Hierarchical Cluster Analysis Based on Clinical and Neuropsychological Symptoms Reveals Distinct Subgroups in Fibromyalgia: A Population-Based Cohort Study
Maurel Ibáñez, Sara Nieves
Dolor crònic
Fatiga
Fibromiàlgia - Tractament
DISEASES::Musculoskeletal Diseases::Muscular Diseases::Fibromyalgia
Other subheadings::Other subheadings::/therapy
DISEASES::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Neurologic Manifestations::Pain::Chronic Pain
DISEASES::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Fatigue
ENFERMEDADES::enfermedades musculoesqueléticas::enfermedades musculares::fibromialgia
Otros calificadores::Otros calificadores::/terapia
ENFERMEDADES::afecciones patológicas, signos y síntomas::signos y síntomas::manifestaciones neurológicas::dolor::dolor crónico
ENFERMEDADES::afecciones patológicas, signos y síntomas::signos y síntomas::fatiga
title_short Hierarchical Cluster Analysis Based on Clinical and Neuropsychological Symptoms Reveals Distinct Subgroups in Fibromyalgia: A Population-Based Cohort Study
title_full Hierarchical Cluster Analysis Based on Clinical and Neuropsychological Symptoms Reveals Distinct Subgroups in Fibromyalgia: A Population-Based Cohort Study
title_fullStr Hierarchical Cluster Analysis Based on Clinical and Neuropsychological Symptoms Reveals Distinct Subgroups in Fibromyalgia: A Population-Based Cohort Study
title_full_unstemmed Hierarchical Cluster Analysis Based on Clinical and Neuropsychological Symptoms Reveals Distinct Subgroups in Fibromyalgia: A Population-Based Cohort Study
title_sort Hierarchical Cluster Analysis Based on Clinical and Neuropsychological Symptoms Reveals Distinct Subgroups in Fibromyalgia: A Population-Based Cohort Study
dc.creator.none.fl_str_mv Maurel Ibáñez, Sara Nieves
Giménez-Llort, Lydia
Alegre, Jose
Castro-Marrero, Jesus
author Maurel Ibáñez, Sara Nieves
author_facet Maurel Ibáñez, Sara Nieves
Giménez-Llort, Lydia
Alegre, Jose
Castro-Marrero, Jesus
author_role author
author2 Giménez-Llort, Lydia
Alegre, Jose
Castro-Marrero, Jesus
author2_role author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Maurel S] Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Giménez-Llort L] Departament de Psiquiatria i Medicina Forense, Escola de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. Institut de Neurociències, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Alegre-Martin J] Grup de Recerca de Reumatologia, Unitat d’Encefalomielitis Miàlgica/Síndrome de Fatiga Crònica (EM/SFC), Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Grup de Recerca de Reumatologia, Unitat d’Encefalomielitis Miàlgica/Síndrome de Fatiga Crònica (EM/SFC), Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Castro-Marrero J] Grup de Recerca de Reumatologia, Unitat d’Encefalomielitis Miàlgica/Síndrome de Fatiga Crònica (EM/SFC), Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Dolor crònic
Fatiga
Fibromiàlgia - Tractament
DISEASES::Musculoskeletal Diseases::Muscular Diseases::Fibromyalgia
Other subheadings::Other subheadings::/therapy
DISEASES::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Neurologic Manifestations::Pain::Chronic Pain
DISEASES::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Fatigue
ENFERMEDADES::enfermedades musculoesqueléticas::enfermedades musculares::fibromialgia
Otros calificadores::Otros calificadores::/terapia
ENFERMEDADES::afecciones patológicas, signos y síntomas::signos y síntomas::manifestaciones neurológicas::dolor::dolor crónico
ENFERMEDADES::afecciones patológicas, signos y síntomas::signos y síntomas::fatiga
topic Dolor crònic
Fatiga
Fibromiàlgia - Tractament
DISEASES::Musculoskeletal Diseases::Muscular Diseases::Fibromyalgia
Other subheadings::Other subheadings::/therapy
DISEASES::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Neurologic Manifestations::Pain::Chronic Pain
DISEASES::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Fatigue
ENFERMEDADES::enfermedades musculoesqueléticas::enfermedades musculares::fibromialgia
Otros calificadores::Otros calificadores::/terapia
ENFERMEDADES::afecciones patológicas, signos y síntomas::signos y síntomas::manifestaciones neurológicas::dolor::dolor crónico
ENFERMEDADES::afecciones patológicas, signos y síntomas::signos y síntomas::fatiga
description Cluster analysis; Fibromyalgia; Neuropsychological symptoms
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/10577
http://hdl.handle.net/11351/10577
url https://hdl.handle.net/11351/10577
http://hdl.handle.net/11351/10577
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Biomedicines;11(10)
https://doi.org/10.3390/biomedicines11102867
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Scientia
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869423880989310976
spelling Hierarchical Cluster Analysis Based on Clinical and Neuropsychological Symptoms Reveals Distinct Subgroups in Fibromyalgia: A Population-Based Cohort StudyMaurel Ibáñez, Sara NievesGiménez-Llort, LydiaAlegre, JoseCastro-Marrero, JesusDolor crònicFatigaFibromiàlgia - TractamentDISEASES::Musculoskeletal Diseases::Muscular Diseases::FibromyalgiaOther subheadings::Other subheadings::/therapyDISEASES::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Neurologic Manifestations::Pain::Chronic PainDISEASES::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::FatigueENFERMEDADES::enfermedades musculoesqueléticas::enfermedades musculares::fibromialgiaOtros calificadores::Otros calificadores::/terapiaENFERMEDADES::afecciones patológicas, signos y síntomas::signos y síntomas::manifestaciones neurológicas::dolor::dolor crónicoENFERMEDADES::afecciones patológicas, signos y síntomas::signos y síntomas::fatigaCluster analysis; Fibromyalgia; Neuropsychological symptomsAnálisis de clústers; Fibromialgia; Síntomas neuropsicológicosAnàlisi de clústers; Fibromiàlgia; Símptomes neuropsicològicsFibromyalgia (FM) is a condition characterized by musculoskeletal pain and multiple comorbidities. Our study aimed to identify four clusters of FM patients according to their core clinical symptoms and neuropsychological comorbidities to identify possible therapeutic targets in the condition. We performed a population-based cohort study on 251 adult FM patients referred to primary care according to the 2010 ACR case criteria. Patients were aggregated in clusters by a K-medians hierarchical cluster analysis based on physical and emotional symptoms and neuropsychological variables. Four different clusters were identified in the FM population. Global cluster analysis reported a four-cluster profile (cluster 1: pain, fatigue, poorer sleep quality, stiffness, anxiety/depression and disability at work; cluster 2: injustice, catastrophizing, positive affect and negative affect; cluster 3: mindfulness and acceptance; and cluster 4: surrender). The second analysis on clinical symptoms revealed three distinct subgroups (cluster 1: fatigue, poorer sleep quality, stiffness and difficulties at work; cluster 2: pain; and cluster 3: anxiety and depression). The third analysis of neuropsychological variables provided two opposed subgroups (cluster 1: those with high scores in surrender, injustice, catastrophizing and negative affect, and cluster 2: those with high scores in acceptance, positive affect and mindfulness). These empirical results support models that assume an interaction between neurobiological, psychological and social factors beyond the classical biomedical model. A detailed assessment of such risk and protective factors is critical to differentiate FM subtypes, allowing for further identification of their specific needs and designing tailored personalized therapeutic interventions.This work was partially supported by the National Institute of Health “Carlos III” in Madrid, Spain through the grant (reference number: PI09/90301).MDPIInstitut Català de la Salut[Maurel S] Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Giménez-Llort L] Departament de Psiquiatria i Medicina Forense, Escola de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. Institut de Neurociències, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Alegre-Martin J] Grup de Recerca de Reumatologia, Unitat d’Encefalomielitis Miàlgica/Síndrome de Fatiga Crònica (EM/SFC), Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Grup de Recerca de Reumatologia, Unitat d’Encefalomielitis Miàlgica/Síndrome de Fatiga Crònica (EM/SFC), Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Castro-Marrero J] Grup de Recerca de Reumatologia, Unitat d’Encefalomielitis Miàlgica/Síndrome de Fatiga Crònica (EM/SFC), Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, SpainVall d'Hebron Barcelona Hospital Campus202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/10577http://hdl.handle.net/11351/10577Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésBiomedicines;11(10)https://doi.org/10.3390/biomedicines11102867Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/105772026-05-29T05:05:01Z
score 15,811543

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