Regulation of Adaptive Thermogenesis and Browning by Prebiotics and Postbiotics

Prebiotics are non-digestible food components able to modify host microbiota toward a healthy profile, concomitantly conferring general beneficial health effects. Numerous research works have provided wide evidence regarding the effects of prebiotics on the protection against different detrimental p...

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Detalles Bibliográficos
Autores: Reynes, Barbara, Palou, Mariona, Rodriguez, Ana M, Palou, Andreu
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/22704
Acceso en línea:https://hdl.handle.net/20.500.12105/22704
Access Level:acceso abierto
Palabra clave:Beige adipocytes
Brite adipocytes
Brown adipose tissue
Microbiota
Obesity
Prebiotics
Postbiotics
UCP1
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spelling Regulation of Adaptive Thermogenesis and Browning by Prebiotics and PostbioticsReynes, BarbaraPalou, MarionaRodriguez, Ana MPalou, AndreuBeige adipocytesBrite adipocytesBrown adipose tissueMicrobiotaObesityPrebioticsPostbioticsUCP1Prebiotics are non-digestible food components able to modify host microbiota toward a healthy profile, concomitantly conferring general beneficial health effects. Numerous research works have provided wide evidence regarding the effects of prebiotics on the protection against different detrimental phenotypes related to cancer, immunity, and features of the metabolic syndrome, among others. Nonetheless, one topic less studied so far, but relevant, relates to the connection between prebiotics and energy metabolism regulation (and the prevention or treatment of obesity), especially by means of their impact on adaptive (non-shivering) thermogenesis in brown adipose tissue (BAT) and in the browning of white adipose tissue (WAT). In the present review, a key link between prebiotics and the regulation of adaptive thermogenesis and lipid metabolism (in both BAT and WAT) is proposed, thus connecting prebiotic consumption, microbiota selection (especially gut microbiota), production of microbiota metabolites, and the regulation of energy metabolism in adipose tissue, particularly regarding the effects on browning promotion, or on BAT recruitment. In this sense, various types of prebiotics, from complex carbohydrates to phenolic compounds, have been studied regarding their microbiota-modulating role and their effects on crucial tissues for energy metabolism, including adipose tissue. Other studies have analyzed the effects of the main metabolites produced by selected microbiota on the improvement of metabolism, such as short chain fatty acids and secondary bile acids. Here, we focus on state-of-the-art evidence to demonstrate that different prebiotics can have an impact on energy metabolism and the prevention or treatment of obesity (and its associated disorders) by inducing or regulating adaptive thermogenic capacity in WAT and/or BAT, through modulation of microbiota and their derived metabolites.Frontiers Media20242024-09-1020192019-01-1020192019-01-10review articlehttp://purl.org/coar/resource_type/c_dcae04bcinfo:eu-repo/semantics/articlehttps://hdl.handle.net/20.500.12105/22704reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/227042026-06-12T12:43:37Z
dc.title.none.fl_str_mv Regulation of Adaptive Thermogenesis and Browning by Prebiotics and Postbiotics
title Regulation of Adaptive Thermogenesis and Browning by Prebiotics and Postbiotics
spellingShingle Regulation of Adaptive Thermogenesis and Browning by Prebiotics and Postbiotics
Reynes, Barbara
Beige adipocytes
Brite adipocytes
Brown adipose tissue
Microbiota
Obesity
Prebiotics
Postbiotics
UCP1
title_short Regulation of Adaptive Thermogenesis and Browning by Prebiotics and Postbiotics
title_full Regulation of Adaptive Thermogenesis and Browning by Prebiotics and Postbiotics
title_fullStr Regulation of Adaptive Thermogenesis and Browning by Prebiotics and Postbiotics
title_full_unstemmed Regulation of Adaptive Thermogenesis and Browning by Prebiotics and Postbiotics
title_sort Regulation of Adaptive Thermogenesis and Browning by Prebiotics and Postbiotics
dc.creator.none.fl_str_mv Reynes, Barbara
Palou, Mariona
Rodriguez, Ana M
Palou, Andreu
author Reynes, Barbara
author_facet Reynes, Barbara
Palou, Mariona
Rodriguez, Ana M
Palou, Andreu
author_role author
author2 Palou, Mariona
Rodriguez, Ana M
Palou, Andreu
author2_role author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Beige adipocytes
Brite adipocytes
Brown adipose tissue
Microbiota
Obesity
Prebiotics
Postbiotics
UCP1
topic Beige adipocytes
Brite adipocytes
Brown adipose tissue
Microbiota
Obesity
Prebiotics
Postbiotics
UCP1
description Prebiotics are non-digestible food components able to modify host microbiota toward a healthy profile, concomitantly conferring general beneficial health effects. Numerous research works have provided wide evidence regarding the effects of prebiotics on the protection against different detrimental phenotypes related to cancer, immunity, and features of the metabolic syndrome, among others. Nonetheless, one topic less studied so far, but relevant, relates to the connection between prebiotics and energy metabolism regulation (and the prevention or treatment of obesity), especially by means of their impact on adaptive (non-shivering) thermogenesis in brown adipose tissue (BAT) and in the browning of white adipose tissue (WAT). In the present review, a key link between prebiotics and the regulation of adaptive thermogenesis and lipid metabolism (in both BAT and WAT) is proposed, thus connecting prebiotic consumption, microbiota selection (especially gut microbiota), production of microbiota metabolites, and the regulation of energy metabolism in adipose tissue, particularly regarding the effects on browning promotion, or on BAT recruitment. In this sense, various types of prebiotics, from complex carbohydrates to phenolic compounds, have been studied regarding their microbiota-modulating role and their effects on crucial tissues for energy metabolism, including adipose tissue. Other studies have analyzed the effects of the main metabolites produced by selected microbiota on the improvement of metabolism, such as short chain fatty acids and secondary bile acids. Here, we focus on state-of-the-art evidence to demonstrate that different prebiotics can have an impact on energy metabolism and the prevention or treatment of obesity (and its associated disorders) by inducing or regulating adaptive thermogenic capacity in WAT and/or BAT, through modulation of microbiota and their derived metabolites.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-10
2019
2019-01-10
2024
2024-09-10
dc.type.none.fl_str_mv review article
http://purl.org/coar/resource_type/c_dcae04bc
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.12105/22704
url https://hdl.handle.net/20.500.12105/22704
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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