ICAMs in Immunity, Intercellular Adhesion and Communication.

Interactions among leukocytes and leukocytes with immune-associated auxiliary cells represent an essential feature of the immune response that requires the involvement of cell adhesion molecules (CAMs). In the immune system, CAMs include a wide range of members pertaining to different structural and...

Descripción completa

Detalles Bibliográficos
Autores: Guerra-Espinosa, Claudia, Jiménez-Fernández, María, Sánchez-Madrid, Francisco, Serrador, Juan M
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/20362
Acceso en línea:http://hdl.handle.net/20.500.12105/20362
Access Level:acceso abierto
Palabra clave:Endothelial Cells
Cell Adhesion Molecules
Humans
Lymphocyte Function-Associated Antigen-1
Macrophage-1 Antigen
CD18 Antigens
Communication
id ES_ef7bba730db174c86952f0cefcc7342e
oai_identifier_str oai:repisalud.isciii.es:20.500.12105/20362
network_acronym_str ES
network_name_str España
repository_id_str
spelling ICAMs in Immunity, Intercellular Adhesion and Communication.Guerra-Espinosa, ClaudiaJiménez-Fernández, MaríaSánchez-Madrid, FranciscoSerrador, Juan MEndothelial CellsCell Adhesion MoleculesHumansLymphocyte Function-Associated Antigen-1Macrophage-1 AntigenCD18 AntigensCommunicationInteractions among leukocytes and leukocytes with immune-associated auxiliary cells represent an essential feature of the immune response that requires the involvement of cell adhesion molecules (CAMs). In the immune system, CAMs include a wide range of members pertaining to different structural and functional families involved in cell development, activation, differentiation and migration. Among them, β2 integrins (LFA-1, Mac-1, p150,95 and αDβ2) are predominantly involved in homotypic and heterotypic leukocyte adhesion. β2 integrins bind to intercellular (I)CAMs, actin cytoskeleton-linked receptors belonging to immunoglobulin superfamily (IgSF)-CAMs expressed by leukocytes and vascular endothelial cells, enabling leukocyte activation and transendothelial migration. β2 integrins have long been viewed as the most important ICAMs partners, propagating intracellular signalling from β2 integrin-ICAM adhesion receptor interaction. In this review, we present previous evidence from pioneering studies and more recent findings supporting an important role for ICAMs in signal transduction. We also discuss the contribution of immune ICAMs (ICAM-1, -2, and -3) to reciprocal cell signalling and function in processes in which β2 integrins supposedly take the lead, paying particular attention to T cell activation, differentiation and migration.Multidisciplinary Digital Publishing Institute (MDPI)Ministerio de Ciencia, Innovación y Universidades (España)Fundación La CaixaInstituto de Salud Carlos IIIMinisterio de Ciencia e Innovación (España)Fundación ProCNIC20242024-07-0920242024-02-1420242024-02-14review articlehttp://purl.org/coar/resource_type/c_dcae04bcVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/20362reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/203622026-06-12T12:43:37Z
dc.title.none.fl_str_mv ICAMs in Immunity, Intercellular Adhesion and Communication.
title ICAMs in Immunity, Intercellular Adhesion and Communication.
spellingShingle ICAMs in Immunity, Intercellular Adhesion and Communication.
Guerra-Espinosa, Claudia
Endothelial Cells
Cell Adhesion Molecules
Humans
Lymphocyte Function-Associated Antigen-1
Macrophage-1 Antigen
CD18 Antigens
Communication
title_short ICAMs in Immunity, Intercellular Adhesion and Communication.
title_full ICAMs in Immunity, Intercellular Adhesion and Communication.
title_fullStr ICAMs in Immunity, Intercellular Adhesion and Communication.
title_full_unstemmed ICAMs in Immunity, Intercellular Adhesion and Communication.
title_sort ICAMs in Immunity, Intercellular Adhesion and Communication.
dc.creator.none.fl_str_mv Guerra-Espinosa, Claudia
Jiménez-Fernández, María
Sánchez-Madrid, Francisco
Serrador, Juan M
author Guerra-Espinosa, Claudia
author_facet Guerra-Espinosa, Claudia
Jiménez-Fernández, María
Sánchez-Madrid, Francisco
Serrador, Juan M
author_role author
author2 Jiménez-Fernández, María
Sánchez-Madrid, Francisco
Serrador, Juan M
author2_role author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Fundación La Caixa
Instituto de Salud Carlos III
Ministerio de Ciencia e Innovación (España)
Fundación ProCNIC
dc.subject.none.fl_str_mv Endothelial Cells
Cell Adhesion Molecules
Humans
Lymphocyte Function-Associated Antigen-1
Macrophage-1 Antigen
CD18 Antigens
Communication
topic Endothelial Cells
Cell Adhesion Molecules
Humans
Lymphocyte Function-Associated Antigen-1
Macrophage-1 Antigen
CD18 Antigens
Communication
description Interactions among leukocytes and leukocytes with immune-associated auxiliary cells represent an essential feature of the immune response that requires the involvement of cell adhesion molecules (CAMs). In the immune system, CAMs include a wide range of members pertaining to different structural and functional families involved in cell development, activation, differentiation and migration. Among them, β2 integrins (LFA-1, Mac-1, p150,95 and αDβ2) are predominantly involved in homotypic and heterotypic leukocyte adhesion. β2 integrins bind to intercellular (I)CAMs, actin cytoskeleton-linked receptors belonging to immunoglobulin superfamily (IgSF)-CAMs expressed by leukocytes and vascular endothelial cells, enabling leukocyte activation and transendothelial migration. β2 integrins have long been viewed as the most important ICAMs partners, propagating intracellular signalling from β2 integrin-ICAM adhesion receptor interaction. In this review, we present previous evidence from pioneering studies and more recent findings supporting an important role for ICAMs in signal transduction. We also discuss the contribution of immune ICAMs (ICAM-1, -2, and -3) to reciprocal cell signalling and function in processes in which β2 integrins supposedly take the lead, paying particular attention to T cell activation, differentiation and migration.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-07-09
2024
2024-02-14
2024
2024-02-14
dc.type.none.fl_str_mv review article
http://purl.org/coar/resource_type/c_dcae04bc
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/20362
url http://hdl.handle.net/20.500.12105/20362
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869423867905179648
score 15,81155

Similares en LA Referencia