Neuromelanin and selective neuronal vulnerability to Parkinson’s disease
Aging; Neurodegeneration; Substantia nigra
| Autores: | , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Departament de Salut de la Generalitat de Catalunya (DS) |
| Repositorio: | Scientia. Dipòsit d'Informació Digital del Departament de Salut |
| OAI Identifier: | oai:scientiasalut.gencat.cat:11351/13358 |
| Acceso en línea: | http://hdl.handle.net/11351/13358 |
| Access Level: | acceso abierto |
| Palabra clave: | Parkinson, Malaltia de Neurones dopaminèrgiques DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Basal Ganglia Diseases::Parkinsonian Disorders::Parkinson Disease CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Amino Acids::Amino Acids, Cyclic::Amino Acids, Aromatic::Tyrosine::Melanins ANATOMY::Nervous System::Neurons::Dopaminergic Neurons CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Nerve Tissue Proteins::Synucleins::alpha-Synuclein ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::enfermedades de los ganglios basales::trastornos parkinsonianos::enfermedad de Parkinson COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::aminoácidos::aminoácidos cíclicos::aminoácidos aromáticos::tirosina::melaninas ANATOMÍA::sistema nervioso::neuronas::neuronas dopaminérgicas COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas del tejido nervioso::sinucleínas::alfa-sinucleína |
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Neuromelanin and selective neuronal vulnerability to Parkinson’s diseaseFilimontseva, AnastasiaFu, YuHongVila, MiquelHalliday, GlendaParkinson, Malaltia deNeurones dopaminèrgiquesDISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Basal Ganglia Diseases::Parkinsonian Disorders::Parkinson DiseaseCHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Amino Acids::Amino Acids, Cyclic::Amino Acids, Aromatic::Tyrosine::MelaninsANATOMY::Nervous System::Neurons::Dopaminergic NeuronsCHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Nerve Tissue Proteins::Synucleins::alpha-SynucleinENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::enfermedades de los ganglios basales::trastornos parkinsonianos::enfermedad de ParkinsonCOMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::aminoácidos::aminoácidos cíclicos::aminoácidos aromáticos::tirosina::melaninasANATOMÍA::sistema nervioso::neuronas::neuronas dopaminérgicasCOMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas del tejido nervioso::sinucleínas::alfa-sinucleínaAging; Neurodegeneration; Substantia nigraEnvelliment; Neurodegeneració; Substància negraEnvejecimiento; Neurodegeneración; Sustancia negraNeuromelanin is a unique pigment made by some human catecholamine neurons. These neurons survive with their neuromelanin content for a lifetime but can also be affected by age-related neurodegenerative conditions, as observed using new neuromelanin imaging techniques. The limited quantities of neuromelanin has made understanding its normal biology difficult, but recent rodent and primate models, as well as omics studies, have confirmed its importance for selective neuronal loss in Parkinson’s disease (PD). We review the development of neuromelanin in dopamine versus noradrenaline neurons and focus on previously overlooked cellular organelles in neuromelanin formation and function. We discuss the role of neuromelanin in stimulating endogenous α-synuclein misfolding in PD which renders neuromelanin granules vulnerable, and can exacerbates other pathogenic processes.This work was supported in part by Aligning Science Across Parkinson’s [020505] through the Michael J. Fox Foundation for Parkinson’s Research (MJFF) and also by funding to GH from the National Health and Medical Research Council of Australia [Investigator Grant 1176607]. For open access, the authors have applied a CC BY public copyright license to all Author Accepted Manuscripts arising from this submission. We would like to thank Heidi Cartwright for assistance with the figures.ElsevierInstitut Català de la Salut[Filimontseva A, Fu Y, Halliday GM] Brain and Mind Centre & Faculty of Medicine and Health School of Medical Sciences, The University of Sydney, Sydney, NSW, Australia. Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, MD, USA. [Vila M] Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, MD, USA. Grup de Recerca de Malalties Neurodegeneratives, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona, Spain. Department of Biochemistry and Molecular Biology, Institute of Neuroscience, Autonomous University of Barcelona, Bellaterra, Spain. Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202520252025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/11351/13358Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésTrends in Neurosciences;48(6)https://doi.org/10.1016/j.tins.2025.04.005Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/133582026-06-12T09:38:37Z |
| dc.title.none.fl_str_mv |
Neuromelanin and selective neuronal vulnerability to Parkinson’s disease |
| title |
Neuromelanin and selective neuronal vulnerability to Parkinson’s disease |
| spellingShingle |
Neuromelanin and selective neuronal vulnerability to Parkinson’s disease Filimontseva, Anastasia Parkinson, Malaltia de Neurones dopaminèrgiques DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Basal Ganglia Diseases::Parkinsonian Disorders::Parkinson Disease CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Amino Acids::Amino Acids, Cyclic::Amino Acids, Aromatic::Tyrosine::Melanins ANATOMY::Nervous System::Neurons::Dopaminergic Neurons CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Nerve Tissue Proteins::Synucleins::alpha-Synuclein ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::enfermedades de los ganglios basales::trastornos parkinsonianos::enfermedad de Parkinson COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::aminoácidos::aminoácidos cíclicos::aminoácidos aromáticos::tirosina::melaninas ANATOMÍA::sistema nervioso::neuronas::neuronas dopaminérgicas COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas del tejido nervioso::sinucleínas::alfa-sinucleína |
| title_short |
Neuromelanin and selective neuronal vulnerability to Parkinson’s disease |
| title_full |
Neuromelanin and selective neuronal vulnerability to Parkinson’s disease |
| title_fullStr |
Neuromelanin and selective neuronal vulnerability to Parkinson’s disease |
| title_full_unstemmed |
Neuromelanin and selective neuronal vulnerability to Parkinson’s disease |
| title_sort |
Neuromelanin and selective neuronal vulnerability to Parkinson’s disease |
| dc.creator.none.fl_str_mv |
Filimontseva, Anastasia Fu, YuHong Vila, Miquel Halliday, Glenda |
| author |
Filimontseva, Anastasia |
| author_facet |
Filimontseva, Anastasia Fu, YuHong Vila, Miquel Halliday, Glenda |
| author_role |
author |
| author2 |
Fu, YuHong Vila, Miquel Halliday, Glenda |
| author2_role |
author author author |
| dc.contributor.none.fl_str_mv |
Institut Català de la Salut [Filimontseva A, Fu Y, Halliday GM] Brain and Mind Centre & Faculty of Medicine and Health School of Medical Sciences, The University of Sydney, Sydney, NSW, Australia. Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, MD, USA. [Vila M] Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, MD, USA. Grup de Recerca de Malalties Neurodegeneratives, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Barcelona, Spain. Department of Biochemistry and Molecular Biology, Institute of Neuroscience, Autonomous University of Barcelona, Bellaterra, Spain. Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain Vall d'Hebron Barcelona Hospital Campus |
| dc.subject.none.fl_str_mv |
Parkinson, Malaltia de Neurones dopaminèrgiques DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Basal Ganglia Diseases::Parkinsonian Disorders::Parkinson Disease CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Amino Acids::Amino Acids, Cyclic::Amino Acids, Aromatic::Tyrosine::Melanins ANATOMY::Nervous System::Neurons::Dopaminergic Neurons CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Nerve Tissue Proteins::Synucleins::alpha-Synuclein ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::enfermedades de los ganglios basales::trastornos parkinsonianos::enfermedad de Parkinson COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::aminoácidos::aminoácidos cíclicos::aminoácidos aromáticos::tirosina::melaninas ANATOMÍA::sistema nervioso::neuronas::neuronas dopaminérgicas COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas del tejido nervioso::sinucleínas::alfa-sinucleína |
| topic |
Parkinson, Malaltia de Neurones dopaminèrgiques DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Basal Ganglia Diseases::Parkinsonian Disorders::Parkinson Disease CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Amino Acids::Amino Acids, Cyclic::Amino Acids, Aromatic::Tyrosine::Melanins ANATOMY::Nervous System::Neurons::Dopaminergic Neurons CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Nerve Tissue Proteins::Synucleins::alpha-Synuclein ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::enfermedades de los ganglios basales::trastornos parkinsonianos::enfermedad de Parkinson COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::aminoácidos::aminoácidos cíclicos::aminoácidos aromáticos::tirosina::melaninas ANATOMÍA::sistema nervioso::neuronas::neuronas dopaminérgicas COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas del tejido nervioso::sinucleínas::alfa-sinucleína |
| description |
Aging; Neurodegeneration; Substantia nigra |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2025 2025 2025 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
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publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11351/13358 |
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http://hdl.handle.net/11351/13358 |
| dc.language.none.fl_str_mv |
Inglés |
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Inglés |
| dc.relation.none.fl_str_mv |
Trends in Neurosciences;48(6) https://doi.org/10.1016/j.tins.2025.04.005 |
| dc.rights.none.fl_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
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Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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Elsevier |
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Elsevier |
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Scientia reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut instname:Departament de Salut de la Generalitat de Catalunya (DS) |
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Departament de Salut de la Generalitat de Catalunya (DS) |
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Scientia. Dipòsit d'Informació Digital del Departament de Salut |
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Scientia. Dipòsit d'Informació Digital del Departament de Salut |
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1869423866123649024 |
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15,81155 |