The Effectiveness of Topical Treatment for Plantar Warts: A Retrospective Cohort Study

Abstract: Background: Plantar warts, caused by human papillomavirus (HPV), are a common condition that can be painful and resistant to treatment. There are various therapeutic options for managing them, but it is not always clear which are the most effective and tolerated by patients. Among the most...

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Autores: Rayo Pérez, Ana María, Juárez Jiménez, José María, Rayo Rosado, Rafael, García de la Peña, Raquel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/166412
Acceso en línea:https://hdl.handle.net/11441/166412
https://doi.org/10.3390/idr16060090
Access Level:acceso abierto
Palabra clave:HPV
Plantar wart
Treatment
Effectiveness
Nitric acid
Cantharidin
Bleomycin
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spelling The Effectiveness of Topical Treatment for Plantar Warts: A Retrospective Cohort StudyRayo Pérez, Ana MaríaJuárez Jiménez, José MaríaRayo Rosado, RafaelGarcía de la Peña, RaquelHPVPlantar wartTreatmentEffectivenessNitric acidCantharidinBleomycinAbstract: Background: Plantar warts, caused by human papillomavirus (HPV), are a common condition that can be painful and resistant to treatment. There are various therapeutic options for managing them, but it is not always clear which are the most effective and tolerated by patients. Among the most commonly used treatments are a zinc and nitric complex (nitrizinc complex), cantharidin, and bleomycin, each with different mechanisms of action and profiles in terms of pain and patient satisfaction. Objectives: We aimed to evaluate and compare the clinical efficacy, post treatment pain, and patient satisfaction among three common treatments (zinc and nitric complex, cantharidin, and bleomycin) in subjects with plantar warts, as well as identify the most effective and best-tolerated treatment. Materials and Methods: This is a retrospective case series study analyzing 60 records of subjects aged 18 to 40 years diagnosed with plantar warts without systemic diseases or allergies and without any prior treatment. Complete records from 2020 to 2023 were selected. Subjects were divided into three groups according to the treatment received (zinc and nitric complex, cantharidin, bleomycin), and demographic variables, post-treatment pain (measured using the visual analog scale), the number of sessions required, and satisfaction after discharge (evaluated with the Likert scale) were analyzed. Results: Of the 60 subjects included, the group treated with bleomycin experienced higher levels of pain after the first session (mean of 7.1 points on the VAS) compared to the cantharidin group (2.7 points) and the zinc and nitric complex group). However, the bleomycin group required fewer sessions for complete healing (an average of 1.8 sessions), while the nitric acid group needed more (3.4 sessions), with cantharidin falling in between (2.5 sessions). Regarding post-discharge satisfaction, all groups showed comparable scores (between 7.9 and 8.5 points), although cantharidin demonstrated slightly higher satisfaction. Astatistical analysis showed significant differences in the number of sessions and post-treatment pain between treatments (p < 0.05) but not in final satisfaction. Conclusions: Although bleomycin treatment is more painful, it is the most effective in terms of reducing the number of sessions required for complete healing. Cantharidin offers a good balance between efficacy and patient satisfaction, while a zinc and nitric complex, although less painful, requires more sessions for complete treatment. Each treatment has specific advantages, suggesting that therapeutic choices should be personalized according to the patient’s needs and preferences.MdpiPodología2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/166412https://doi.org/10.3390/idr16060090reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésInfectious Disease Reports, 16 (6), 1108-1117.https://www.mdpi.com/2036-7449/16/6/90info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1664122026-06-17T12:51:07Z
dc.title.none.fl_str_mv The Effectiveness of Topical Treatment for Plantar Warts: A Retrospective Cohort Study
title The Effectiveness of Topical Treatment for Plantar Warts: A Retrospective Cohort Study
spellingShingle The Effectiveness of Topical Treatment for Plantar Warts: A Retrospective Cohort Study
Rayo Pérez, Ana María
HPV
Plantar wart
Treatment
Effectiveness
Nitric acid
Cantharidin
Bleomycin
title_short The Effectiveness of Topical Treatment for Plantar Warts: A Retrospective Cohort Study
title_full The Effectiveness of Topical Treatment for Plantar Warts: A Retrospective Cohort Study
title_fullStr The Effectiveness of Topical Treatment for Plantar Warts: A Retrospective Cohort Study
title_full_unstemmed The Effectiveness of Topical Treatment for Plantar Warts: A Retrospective Cohort Study
title_sort The Effectiveness of Topical Treatment for Plantar Warts: A Retrospective Cohort Study
dc.creator.none.fl_str_mv Rayo Pérez, Ana María
Juárez Jiménez, José María
Rayo Rosado, Rafael
García de la Peña, Raquel
author Rayo Pérez, Ana María
author_facet Rayo Pérez, Ana María
Juárez Jiménez, José María
Rayo Rosado, Rafael
García de la Peña, Raquel
author_role author
author2 Juárez Jiménez, José María
Rayo Rosado, Rafael
García de la Peña, Raquel
author2_role author
author
author
dc.contributor.none.fl_str_mv Podología
dc.subject.none.fl_str_mv HPV
Plantar wart
Treatment
Effectiveness
Nitric acid
Cantharidin
Bleomycin
topic HPV
Plantar wart
Treatment
Effectiveness
Nitric acid
Cantharidin
Bleomycin
description Abstract: Background: Plantar warts, caused by human papillomavirus (HPV), are a common condition that can be painful and resistant to treatment. There are various therapeutic options for managing them, but it is not always clear which are the most effective and tolerated by patients. Among the most commonly used treatments are a zinc and nitric complex (nitrizinc complex), cantharidin, and bleomycin, each with different mechanisms of action and profiles in terms of pain and patient satisfaction. Objectives: We aimed to evaluate and compare the clinical efficacy, post treatment pain, and patient satisfaction among three common treatments (zinc and nitric complex, cantharidin, and bleomycin) in subjects with plantar warts, as well as identify the most effective and best-tolerated treatment. Materials and Methods: This is a retrospective case series study analyzing 60 records of subjects aged 18 to 40 years diagnosed with plantar warts without systemic diseases or allergies and without any prior treatment. Complete records from 2020 to 2023 were selected. Subjects were divided into three groups according to the treatment received (zinc and nitric complex, cantharidin, bleomycin), and demographic variables, post-treatment pain (measured using the visual analog scale), the number of sessions required, and satisfaction after discharge (evaluated with the Likert scale) were analyzed. Results: Of the 60 subjects included, the group treated with bleomycin experienced higher levels of pain after the first session (mean of 7.1 points on the VAS) compared to the cantharidin group (2.7 points) and the zinc and nitric complex group). However, the bleomycin group required fewer sessions for complete healing (an average of 1.8 sessions), while the nitric acid group needed more (3.4 sessions), with cantharidin falling in between (2.5 sessions). Regarding post-discharge satisfaction, all groups showed comparable scores (between 7.9 and 8.5 points), although cantharidin demonstrated slightly higher satisfaction. Astatistical analysis showed significant differences in the number of sessions and post-treatment pain between treatments (p < 0.05) but not in final satisfaction. Conclusions: Although bleomycin treatment is more painful, it is the most effective in terms of reducing the number of sessions required for complete healing. Cantharidin offers a good balance between efficacy and patient satisfaction, while a zinc and nitric complex, although less painful, requires more sessions for complete treatment. Each treatment has specific advantages, suggesting that therapeutic choices should be personalized according to the patient’s needs and preferences.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/166412
https://doi.org/10.3390/idr16060090
url https://hdl.handle.net/11441/166412
https://doi.org/10.3390/idr16060090
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Infectious Disease Reports, 16 (6), 1108-1117.
https://www.mdpi.com/2036-7449/16/6/90
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Mdpi
publisher.none.fl_str_mv Mdpi
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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