Long-term antibiotic therapy in patients with surgery-indicated not undergoing surgery infective endocarditis

Background: To date, there is little information regarding management of patients with infective endocarditis (IE) that did not undergo an indicated surgery. Therefore, we aimed to evaluate prognosis of these patients treated with a long-term antibiotic treatment strategy, including oral long term s...

Descripción completa

Detalles Bibliográficos
Autores: Vallejo Camazon, Nuria, Mateu, Lourdes, Cediel, Germán, Escolà Vergé, Laura, Fernández Hidalgo, Nuria, Gurgui Ferrer, Mercedes, Perez Rodriguez, Maria Teresa, Cuervo Requena, Guillermo, Nuñez Aragón, Raquel, Llibre, Cinta, Sopena, Nieves, Quesada, María Dolores, Berastegui, Elisabeth, Teis, Albert, Lopez Ayerbe, Jorge, Juncà, Gladys, Gual, Francisco, Ferrer Sistach, Elena, Vivero, Ainhoa, Reynaga, Esteban, Hernández Pérez, Maria, Muñoz Guijosa, Christian, Pedro Botet, Lluisa, Bayés Genís, Antoni
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/179795
Acceso en línea:https://hdl.handle.net/2445/179795
Access Level:acceso abierto
Palabra clave:Endocarditis
Antibiòtics
Cirurgia
Antibiotics
Surgery
Descripción
Sumario:Background: To date, there is little information regarding management of patients with infective endocarditis (IE) that did not undergo an indicated surgery. Therefore, we aimed to evaluate prognosis of these patients treated with a long-term antibiotic treatment strategy, including oral long term suppressive antibiotic treatment in five referral centres with a multidisciplinary endocarditis team. Methods: This retrospective, multicenter study retrieved individual patient-level data from five referral centres in Spain. Among a total of 1797, 32 consecutive patients with IE were examined (median age 72 years; 78% males) who had not undergone an indicated surgery, but received long-term antibiotic treatment (LTAT) and were followed by a multidisciplinary endocarditis team, between 2011 and 2019. Primary outcomes were infection relapse and mortality during follow-up. Results: Among 32 patients, 21 had IE associated with prostheses. Of the latter, 8 had an ascending aorta prosthetic graft. In 24 patients, a switch to long-term oral suppressive antibiotic treatment (LOSAT) was considered. The median duration of LOSAT was 277 days. Four patients experienced a relapse during follow-up. One patient died within 60 days, and 12 patients died between 60 days and 3 years. However, only 4 deaths were related to IE. Conclusions: The present study results suggest that a LTAT strategy, including LOSAT, might be considered for patients with IE that cannot undergo an indicated surgery. After hospitalization, they should be followed by a multidisciplinary endocarditis team.

Similares en LA Referencia