Comparison of unidimensional and bidimensional measurements in metastatic non-small cell lung cancer

Tumour response evaluation after chemotherapy has become crucial in the development of many drugs. In contrast to the standard bidimensional WHO criteria, the recently described Response Evaluation Criteria In Solid Tumors are based on unidimensional measurements. The aim of the present study was to...

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Autores: Cortes, J. (Javier)|||/items/1337e19a-ac62-43e4-a2e7-8ba44b48cd40, Diaz-Gonzalez, J.A. (Juan Antonio)|||/items/3f4fb669-f3ec-4e28-bc61-3278443cfecf, Garzon, C. (C.)|||/items/6bb56997-74f0-4d03-b510-de22551600cb, Gurpide-Ayarra, L.A. (Luis Alfonso)|||/items/0935e09d-b036-414b-ac0f-688dbfa94d7f, Arbea-Moreno, L. (Leire)|||/items/076efa2b-de27-4a0c-a3e6-2e321ca22833, Gil-Bazo, I. (Ignacio)|||/items/a92277a7-0a96-4e2f-9bb0-8ac5d222270b, Navarro, V. (V.)|||/items/8191f57b-a3d5-4114-853c-60fb59e506e2, Cambeiro-Vázquez, F.M. (Felix Mauricio)|||/items/cc5a1728-30bd-41d3-bc71-0d5122da2e8a, Nicolas, A.I. (A. I.)|||/items/0c1f9f92-05e7-4d28-9bea-1f591b6a4c29, Martin-Algarra, S. (Salvador)|||/items/2fba8e8b-e087-4ab0-82e3-a4d157f1e0cc, Garcia-Foncillas, J. (Jesús)|||/items/f9f291e8-e98b-4de1-ab28-9d44e04f8a09, Calvo, E. (E.)|||/items/e1429cfb-d4f2-4b94-a218-d38c1138fcce, Rodríguez-Rodríguez, J. (Javier)|||/items/eb216e0c-3040-4db1-82a3-45514feafb00
Tipo de recurso: artículo
Fecha de publicación:2002
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/22735
Acceso en línea:https://hdl.handle.net/10171/22735
Access Level:acceso abierto
Palabra clave:RECIST
Non-small cell lung carcinoma
Chemotherapy
Descripción
Sumario:Tumour response evaluation after chemotherapy has become crucial in the development of many drugs. In contrast to the standard bidimensional WHO criteria, the recently described Response Evaluation Criteria In Solid Tumors are based on unidimensional measurements. The aim of the present study was to compare both methods in patients with metastatic nonsmall cell lung cancer. One hundred and sixty-four patients treated with two cisplatin-paclitaxel-based chemotherapy schedules between June 1994 and December 2000 were analysed. The measurements were reviewed by an independent panel of radiologists. Patient characteristics were: median age of 55 years (range 24 – 77 years) and a male to female ratio of 129 : 35. Adenocarcinoma and squamous carcinoma were the most common histologies. Vinorelbine was the third drug used in 77 patients and gemcitabine in 87. The ratio unidimensional/bidimensional was as follows: response 85 : 85; stable disease 32 : 32; progression 47 : 42 and not assessable 0 : 5. Kappa for agreement between responders was 0.951 (95% CI: 0.795 – 1.0) (P50.001). Both WHO criteria and Response Evaluation Criteria In Solid Tumors give similar results in assessing tumour response in patients with non-small cell lung cancer after chemotherapy. The unidimensional measurement could replace the more complex bidimensional one.

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